Patents by Inventor David Robert Bolin

David Robert Bolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
    Publication number: 20100145047
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: November 18, 2009
    Publication date: June 10, 2010
    Inventors: David Robert Bolin, Stuart Hayden, Yimin Qian, Weiya Yun
  • Diacylglycerol acyltransferase inhibitors
    Patent number: 7714126
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: May 11, 2010
    Assignee: Via Pharmaceuticals, Inc.
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Yimin Qian, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20100113782
    Abstract: Provided herein are compounds of the formula (I): were R1 is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a 4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of triglicerides such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: October 20, 2009
    Publication date: May 6, 2010
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Matthew Michael Hamilton, Nicholas Marcopulos, Lee Apostle McDermott, Yimin Qian
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20100035864
    Abstract: Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type 11 diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: July 23, 2009
    Publication date: February 11, 2010
    Inventors: David Robert Bolin, Stuart Hayden, Yimin Qian
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090170864
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: July 2, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20090163546
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 25, 2009
    Inventors: David Robert Bolin, Jianping Cai, Robert Alan Goodnow, JR.
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090105273
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 23, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Aopstle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090099201
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 16, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090093497
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 9, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Micheal Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20090076275
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 19, 2009
    Inventors: David Robert Bolin, Jianping Cai, Adrian Wai-Hing Cheung, Robert Alan Goodnow, JR., Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Weiya Yun
  • Diacylglycerol acyltransferase inhibitors
    Patent number: 7317125
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: January 8, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: David Robert Bolin, Christophe Michoud
  • Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
    Patent number: 7067529
    Abstract: Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as disclosed in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: June 27, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Shoaqing Chen, Steven Gregory Mischke, Yimin Qian
  • Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
    Patent number: 7037924
    Abstract: Compounds of formula (I) are provided, wherein R1 and R2 are as designated in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: May 2, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Shaoqing Chen, Steven Gregory Mischke, Yimin Qian
  • Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
    Publication number: 20040259910
    Abstract: Compounds of formula I are provided 1
    Type: Application
    Filed: April 19, 2004
    Publication date: December 23, 2004
    Inventors: David Robert Bolin, Shoqing Chen, Steven Gregory Mischke, Yimin Qian
  • Synthesis of VIP analog
    Patent number: 6316593
    Abstract: This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: November 13, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Waleed Danho, Arthur M. Felix
  • Synthesis of VIP analog
    Patent number: 6080837
    Abstract: This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)--NH.sub.2 from four protected peptide fragments.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: June 27, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Waleed Danho, Arthur M. Felix
  • Cyclic vasoactive peptide analogs
    Patent number: 5677419
    Abstract: Analogs of porcine Vasoactive Intestinal Peptide are disclosed. The analogs have been cyclized by the covalent attachment, via an amide bond, of the side-chain carboxy terminus of one amino acid in the peptide chain to the side-chain amino terminus of another amino acid in the peptide chain. The claimed compounds are useful for the treatment of asthma.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: October 14, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Margaret O'Donnell