Patents by Inventor David Robert Brittain

David Robert Brittain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
    Patent number: 6967216
    Abstract: Compounds of formula (I): wherein: X is a group of formula (A) or (B): and R1, R2, R3, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being are also described.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: November 22, 2005
    Assignee: AstraZeneca AB
    Inventors: Michael Howard Block, Craig Samuel Donald, David Robert Brittain, Kevin Michael Foote
  • Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor
    Publication number: 20030225097
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: November 5, 2002
    Publication date: December 4, 2003
    Inventors: Michael Howard Block, Craig Samuel Donald, David Robert Brittain, Kevin Michael Foote
  • Bicyclic heteroaryl compounds as inhibitors of the interaction between the integrin alpha4beta1 receptor and vcam-1 and/or fibronectin
    Publication number: 20030181498
    Abstract: A compound of formual (I) or pharmaceutically acceptable salts or derivatives thereof; wherein variables are as defined in the specification. The compounds are useful in the treatment of disease mediated by the interaction between VCAM-1 and/or fibronectin and the integrin receptor &agr;4&bgr;1. Pharmaceutical compositions and methods of use or treatment are also described and claimed.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 25, 2003
    Applicant: AstraZeneca AB
    Inventors: David Robert Brittain, Michael Stewart Large, Gareth Morse Davies
  • Heterocyclic derivatives
    Patent number: 5919793
    Abstract: Compounds of formula (I) wherein R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; or R.sup.1 and R.sup.2 are joined together so that CR.sup.1 14 CR.sup.2 is a double bond; X is selected from --Ch.sub.2 CH.sub.2 --, --C.dbd.CH--, --C.tbd.C--, --CH.sub.2 O--, --OCH.sub.2, CH.sub.2 NH--, --NHCH.sub.2 --, --CH.sub.2 CO--, --COCH.sub.2 --, --CH.sub.2 S(O).sub.n -- and --S(O).sub.n CH.sub.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 6, 1999
    Assignee: Zeneca Limited
    Inventors: George Robert Brown, Paul Robert Owen Whittamore, David Robert Brittain
  • Quinuclidine derivatives as squalene synthase inhibitors
    Patent number: 5714496
    Abstract: Compounds of formula (I) and their pharmaceutically acceptable salts in which R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; or R.sup.1 and R.sup.2 are joined together so that CR.sup.1 -CR.sup.2 is a double bond; X is selected from --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 O--, --CH.sub.2 NH--, --NHCH.sub.2 --, --CH.sub.2 CO--, --COCH.sub.2 --, --CH.sub.2 S-- and --SCH.sub.2 --; Ar.sup.1 is a phenylene moiety; Ar.sup.2 is a heteroaryl moiety; and wherein one or both of Ar.sup.1 and Ar.sup.2 may optionally bear one or more substituents independently selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, di-alkylamino, N-alkylcarbamoyl, di-N,N-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, halogeno-alkyl, carboxyalkyl and alkanoylamino; provided that when R.sup.1 is hydroxy, X is not selected from --NHCH.sub.2 -- and --SCH.sub.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: February 3, 1998
    Assignee: Zeneca Limited
    Inventors: George Robert Brown, Keith Blakeney Mallion, Paul Robert Owen Whittamore, David Robert Brittain
  • Alkanoic acid 2-quinoline derivatives
    Patent number: 4066651
    Abstract: Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: January 3, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventors: David Robert Brittain, Edward Douglas Brown, Walter Hepworth, Gilbert Joseph Stacey