Patents by Inventor David Robert Jaap

David Robert Jaap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders
    Patent number: 7838518
    Abstract: The present invention relates to 1-arylsulfonyl-3 substituted indole or indoline derivatives having the general formula (I) (I) wherein the dotted line represents an optional bond; n is 0 or 1; m is 0-5 and Ar, R6-R11 are defined in the description. The invention further relates to pharmaceutical compositions comprising said derivatives, and to the use of these 1-arylsulfonyl-3-substituted indole or indoline derivatives in the treatment of central nervous disorders such as psychosis, schizophrenia, manic depressions, depressions, neurological disorders, cognitive enhancement, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease and Huntington's disease.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: November 23, 2010
    Assignee: N.V. Organon
    Inventors: Daniel Spinks, Richard E. Armer, David J. Miller, Zoran Rankovic, Gayle Spinks, Jordi Mestres, David Robert Jaap
  • Substituted piperidine derivatives
    Publication number: 20030149269
    Abstract: The present invention relates to certain novel substituted piperidine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of psychotic disorders.
    Type: Application
    Filed: January 28, 2003
    Publication date: August 7, 2003
    Inventors: Duncan Robertson Rae, David Robert Jaap
  • Substituted piperidine derivatives
    Publication number: 20020165395
    Abstract: The present invention relates to certain novel substituted piperidine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of psychotic disorders.
    Type: Application
    Filed: April 25, 2002
    Publication date: November 7, 2002
    Inventors: Duncan Robertson Rae, David Robert Jaap
  • Substituted piperidine derivatives
    Publication number: 20020087001
    Abstract: The present invention relates to certain novel substituted piperidine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of psychotic disorders.
    Type: Application
    Filed: January 11, 2002
    Publication date: July 4, 2002
    Inventors: Duncan Robertson Rae, David Robert Jaap
  • Antipsychotic substituted piperidine derivatives
    Patent number: 6365604
    Abstract: The present invention relates to certain novel substituted piperidine derivatives of formula (I) to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of psychotic disorders.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: April 2, 2002
    Assignee: Akzo Nobel NV
    Inventors: Duncan Robertson Rae, David Robert Jaap
  • Diphenylmethylene piperidine derivatives
    Patent number: 5935974
    Abstract: The invention relates to a diphenylmethylene piperidine derivative of the formula ##STR1## wherein n is 1 or 2; or a pharmaceutically acceptable salt thereof, for use in therapy, in particular for use as a dopamine antagonist for the treatment or prophylaxis of psychotic disorders.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: August 10, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Duncan Robertson Rae, David Robert Jaap