Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

Abstract: Systems and methods that yield highly-accurate classification of acoustic and other non-image events, involving pre-processing data from one or more transducers and generating a visual representation of the source as well as associated features and processing, are disclosed. According to certain exemplary implementations herein, such pre-processing steps may be utilized in situations where 1) all impulsive acoustic events have many features in common due to their point source origin and impulsive nature, and/or 2) the error rates that are considered acceptable in general purpose image classification are much higher than the acceptable levels in automatic impulsive incident classification. Further, according to some aspects, the data may be pre-processed in various ways, such as to remove extraneous or irrelevant details and/or perform any required rotation, alignment, scaling, etc. tasks, such that these tasks do not need to be “learned” in a less direct and more expensive manner in the neural network.

Abstract: Systems and methods that yield highly-accurate classification of acoustic and other non-image events, involving pre-processing data from one or more transducers and generating a visual representation of the source as well as associated features and processing, are disclosed. According to certain exemplary implementations herein, such pre-processing steps may be utilized in situations where 1) all impulsive acoustic events have many features in common due to their point source origin and impulsive nature, and/or 2) the error rates that are considered acceptable in general purpose image classification are much higher than the acceptable levels in automatic impulsive incident classification. Further, according to some aspects, the data may be pre-processed in various ways, such as to remove extraneous or irrelevant details and/or perform any required rotation, alignment, scaling, etc. tasks, such that these tasks do not need to be “learned” in a less direct and more expensive manner in the neural network.

Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: Systems and methods that yield highly-accurate classification of acoustic and other non-image events, involving pre-processing data from one or more transducers and generating a visual representation of the source as well as associated features and processing, are disclosed. According to certain exemplary implementations herein, such pre-processing steps may be utilized in situations where 1) all impulsive acoustic events have many features in common due to their point source origin and impulsive nature, and/or 2) the error rates that are considered acceptable in general purpose image classification are much higher than the acceptable levels in automatic impulsive incident classification. Further, according to some aspects, the data may be pre-processed in various ways, such as to remove extraneous or irrelevant details and/or perform any required rotation, alignment, scaling, etc. tasks, such that these tasks do not need to be “learned” in a less direct and more expensive manner in the neural network.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: Systems and methods that yield highly-accurate classification of acoustic and other non-image events, involving pre-processing data from one or more transducers and generating a visual representation of the source as well as associated features and processing, are disclosed. According to certain exemplary implementations herein, such pre-processing steps may be utilized in situations where 1) all impulsive acoustic events have many features in common due to their point source origin and impulsive nature, and/or 2) the error rates that are considered acceptable in general purpose image classification are much higher than the acceptable levels in automatic impulsive incident classification. Further, according to some aspects, the data may be pre-processed in various ways, such as to remove extraneous or irrelevant details and/or perform any required rotation, alignment, scaling, etc. tasks, such that these tasks do not need to be “learned” in a less direct and more expensive manner in the neural network.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: A smart manifold system for monitoring the operation of an HVAC unit includes a smart manifold adapted to obtain measurement data related to the operating conditions of the HVAC unit, and a smart platform adapted to communicate wirelessly with the smart manifold and acquire the measurement data from the smart manifold. The smart platform is also adapted to ensure that measurement data is free from any user manipulation or modification, and to tag any measurement data so ensured as verified data. The smart platform is further adapted to transmit the verified data to a remote platform for at least one of storage, report generation, and the performance of analytics.

Abstract: The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. The smart HVAC manifold system provides a means of quickly and electronically handling the manual data acquisition process which would include component and or system model and serial numbers, equipment location (GPS tagging), customer name, environmental conditions that effect performance and performance measurement (weather data and elevation), and supports photo, voice and text documentation.

Abstract: A method and associated apparatus are described that enables unattended, remotely distributed appliances, such as vending machines, utility meters, thermostats and kitchen appliances (ovens, washing machines, refrigerators, etc.) to be connected inexpensively to each other and to a centrally located server. The apparatus 1) uses relatively simple “personality” modules to adapt the apparatus to the application in combination with a sophisticated core module that provides the intelligence needed to process data locally, to format that data and to transfer it to a remote server and 2) uses existing Internet-based communication links, thereby avoiding the costly proprietary links used with current state-of-the-art solutions.

Abstract: This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.

Abstract: A method and associated apparatus are described that enables unattended, remotely distributed appliances, such as vending machines, utility meters, thermostats and kitchen appliances (ovens, washing machines, refrigerators, etc.) to be connected inexpensively to each other and to a centrally located server. The apparatus 1) uses relatively simple “personality” modules to adapt the apparatus to the application in combination with a sophisticated core module that provides the intelligence needed to process data locally, to format that data and to transfer it to a remote server and 2) uses existing Internet-based communication links, thereby avoiding the costly proprietary links used with current state-of-the-art solutions.

Abstract: A method and associated apparatus are described that enables unattended, remotely distributed appliances, such as vending machines, utility meters, thermostats and kitchen appliances (ovens, washing machines, refrigerators, etc.) to be connected inexpensively to each other and to a centrally located server. The apparatus 1) uses relatively simple “personality” modules to adapt the apparatus to the application in combination with a sophisticated core module that provides the intelligence needed to process data locally, to format that data and to transfer it to a remote server and 2) uses existing Internet-based communication links, thereby avoiding the costly proprietary links used with current state-of-the-art solutions.

Abstract: A method and associated apparatus are described that enables unattended, remotely distributed appliances, such as vending machines, utility meters, thermostats and kitchen appliances (ovens, washing machines, refrigerators, etc.) to be connected inexpensively to each other and to a centrally located server. The apparatus 1) uses relatively simple “personality” modules to adapt the apparatus to the application in combination with a sophisticated core module that provides the intelligence needed to process data locally, to format that data and to transfer it to a remote server and 2) uses existing Internet-based communication links, thereby avoiding the costly proprietary links used with current state-of-the-art solutions.