Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.

Abstract: An image intensifier device includes: an intensifier tube with at least one photocathode, a micro-channel plate and a conversion element, arranged in that order one after another, and an electric power supply module configured to supply at least one respective polarisation voltage to each of the elements of the intensifier tube. The electric power supply module extends in a region located upstream of the photocathode, on the side of the photocathode opposite to the micro-channel plate. Thus, a space is cleared located downstream of the intensifier tube in the direction of travel of the photons and of the electrons in the image intensifier device. This allows reducing the size of the image intensifier device for example by bringing an eyepiece closer.

Abstract: Various embodiments relate to a method for producing a metal-organic framework (MOF) having a desired redox conductivity and including redox-active linkers, having ?-alkyl-ferrocene groups, via de novo solvothermal synthesis. Various embodiments relate to a metal-organic framework (MOF) linker comprising an ?-alkyl-ferrocene group. Various embodiments relate to a metal-organic framework (MOF), having a first plurality of redox-active linkers, each having an ?-alkyl-ferrocene group. The MOF according to various embodiments, may further have one or more redox-inactive linkers. Various embodiments relate to materials, apparatuses, and components that include the MOF according to various embodiments. For example, various embodiments relate to thin-films, bulk powders, or electrodes.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A machine learning system is provided to enhance various aspects of machine learning models. In some aspects. a substantially photorealistic three-dimensional (3D) graphical model of an object is accessed and a set of training images of the 3D graphical mode are generated, the set of training images generated to add imperfections and degrade photorealistic quality of the training images. The set of training images are provided as training data to train an artificial neural network.

Abstract: In various examples, live perception from sensors of a vehicle may be leveraged to detect and classify intersection contention areas in an environment of a vehicle in real-time or near real-time. For example, a deep neural network (DNN) may be trained to compute outputs—such as signed distance functions—that may correspond to locations of boundaries delineating intersection contention areas. The signed distance functions may be decoded and/or post-processed to determine instance segmentation masks representing locations and classifications of intersection areas or regions. The locations of the intersections areas or regions may be generated in image-space and converted to world-space coordinates to aid an autonomous or semi-autonomous vehicle in navigating intersections according to rules of the road, traffic priority considerations, and/or the like.

Abstract: A computer-implemented method for explaining an image classifier, the method comprising: receiving an initial image, the initial image having been wrongly classified by the image classifier; receiving an initial gradient of a function executed by the image classifier generated while classifying the initial image, the function being indicative of a probability for the initial image to belong to an initial class; converting the initial image into a latent vector, the latent vector being a representation of the initial image in a latent space; generating a plurality of perturbation vectors using the initial gradient of the function executed by the image classifier; combining the latent vector with each one of the plurality of perturbation vectors, thereby obtaining a plurality of modified vectors; for each one of the plurality of modified vectors, reconstructing a respective image, thereby obtaining a plurality of reconstructed images; transmitting the reconstructed images to the image classifier; for each one o

Abstract: In a general aspect, a surface code syndrome measurement is performed on a superconducting quantum processing unit. In some implementations, the superconducting quantum processing unit is caused to apply a quantum error correction code including X-type and Z-type stabilizer check patches. Each of the X-type and Z-type stabilizer check patches includes a stabilizer check qubit device and data qubit devices of the superconducting quantum processing unit. Applying the quantum error correction code includes iteratively twirling the data qubit devices in a stabilizer check patch; and evolving the stabilizer check qubit device in the stabilizer check patch and the data qubit devices in the stabilizer check patch under an interaction Hamiltonian. The interaction Hamiltonian includes a plurality of terms interactions between the stabilizer check qubit device in the stabilizer check patch and a respective one of the data qubit devices in the stabilizer check patch.

Abstract: In various examples, live perception from sensors of a vehicle may be leveraged to detect and classify intersections in an environment of a vehicle in real-time or near real-time. For example, a deep neural network (DNN) may be trained to compute various outputs—such as bounding box coordinates for intersections, intersection coverage maps corresponding to the bounding boxes, intersection attributes, distances to intersections, and/or distance coverage maps associated with the intersections. The outputs may be decoded and/or post-processed to determine final locations of, distances to, and/or attributes of the detected intersections.

Abstract: An image intensifier device includes: an intensifier tube with at least one photocathode, a micro-channel plate and a conversion element, arranged in that order one after another, and an electric power supply module configured to supply at least one respective polarisation voltage to each of the elements of the intensifier tube. The electric power supply module extends in a region located upstream of the photocathode, on the side of the photocathode opposite to the micro-channel plate. Thus, a space is cleared located downstream of the intensifier tube in the direction of travel of the photons and of the electrons in the image intensifier device. This allows reducing the size of the image intensifier device for example by bringing an eyepiece closer.

Abstract: An incorrect copy of a record of data can be prevented from being transmitted to a distributed ledger system. A first file can be received and can include information, in audio or video form, with a description of a subject matter of the record of data and with an authorization to transmit the copy to the distributed ledger system. The first file can be sent to a device. A second file can be received from the device and can include information that confirms that the description of the subject matter, included in the first file, is correct, and that confirms that an entity, which controlled production of the first file, has permission to authorize causing the copy to be transmitted to the distributed ledger system. The correct copy can be caused, based on a receipt of the first and the second files, to be transmitted to the distributed ledger system.

Abstract: A neural network may be used to determine corner points of a skewed polygon (e.g., as displacement values to anchor box corner points) that accurately delineate a region in an image that defines a parking space. Further, the neural network may output confidence values predicting likelihoods that corner points of an anchor box correspond to an entrance to the parking spot. The confidence values may be used to select a subset of the corner points of the anchor box and/or skewed polygon in order to define the entrance to the parking spot. A minimum aggregate distance between corner points of a skewed polygon predicted using the CNN(s) and ground truth corner points of a parking spot may be used simplify a determination as to whether an anchor box should be used as a positive sample for training.

Abstract: Described herein are methods of preparing compounds derived from triglycerides or condensation polymers such as polyesters and/or polyamides. The methods may include subjecting triglyceride or condensation polymer containing matter to mechanical processing in the presence of a nucleophile.

Abstract: A first subject of the present invention has an antiviral formulation with metallic copper particles in an unoxidized form and having a median particle diameter inferior or equal to 200 nm, graphene oxide or reduced graphene oxide, and a bonding matrix material. A second subject of the invention has an antiviral filtering material with a layer of textile and at least one layer of an antiviral coating comprising metallic copper particles in an unoxidized form and having a median particle diameter inferior or equal to 200 nm, graphene oxide or reduced graphene oxide, and a bonding matrix into which both metallic copper particles and graphene oxide or reduced graphene oxide are anchored. The invention also concerns methods of preparation of the antiviral formulation and of the antiviral filtering material. Finally, the invention includes an antiviral face mask with a layer of textile coated with the antiviral formulation.

Abstract: A cloud-native global file system, in which one or more filers are associated with a volume of a versioned files system in a private, public or hybrid cloud object store, is augmented to include a rapid ransomware recovery service. Upon detecting a ransomware attack associated with one or more files or directories of the volume, read and write access to the volume is restricted. A recovery filer is then activated or designated in the cloud. A restore operation is then initiated at the recovery filter. Following completion of the restore operation, a new clean (healthy) snapshot of the volume is then created using the recovery filer For any filer other than the recovery filer, a determination is made whether the filer has completed a merge operation with respect to the new clean snapshot. If so, read and write access to the volume is re-enabled from that filer.

Abstract: In various examples, live perception from sensors of a vehicle may be leveraged to detect and classify intersection contention areas in an environment of a vehicle in real-time or near real-time. For example, a deep neural network (DNN) may be trained to compute outputs—such as signed distance functions—that may correspond to locations of boundaries delineating intersection contention areas. The signed distance functions may be decoded and/or post-processed to determine instance segmentation masks representing locations and classifications of intersection areas or regions. The locations of the intersections areas or regions may be generated in image-space and converted to world-space coordinates to aid an autonomous or semi-autonomous vehicle in navigating intersections according to rules of the road, traffic priority considerations, and/or the like.

Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.

Abstract: A surgical drape support for positioning on a patient's chest to support a drape above the patient's nose and mouth includes a main arch defining an inner main surface, an outer main surface, a main crown, a first main base edge, and a second main base edge. A first lower foot extends downward from the first main base edge and away from the outer main surface. A second lower foot extends downward from the second main base edge and away from the outer main surface. A first upper foot and a second upper foot extend upwards and away from the outer main surface to a position above the main crown. When the first lower foot and the second lower foot are positioned on the patient's chest they are configured to support the drape over the patient's nose and mouth.

Abstract: A magnetic adsorbent, including an admixture of an adsorbent and a magnetic material. A system for removing mercury from a fluid stream, the system including, a magnetic adsorbent injection unit for injecting an admixture of powdered activated carbon and magnetic material into the fluid stream; and a particulate removal unit. Also included are methods for removing mercury from a fluid stream and methods for producing a magnetic sorbent.

Abstract: The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.