Patents by Inventor David Rothwarf
David Rothwarf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160023179Abstract: Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Inventors: Christopher D. Herold, David Rothwarf, Bao Nguyen
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Patent number: 9152905Abstract: Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.Type: GrantFiled: January 23, 2008Date of Patent: October 6, 2015Assignee: ARRAYOMICS, INC.Inventors: Christopher D. Herold, David Rothwarf, Bao Nguyen
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Publication number: 20150018245Abstract: Systems and methods for arranging microdevices on an array substrate are described. Each microdevice contains a lipid bilayer region and a patterned magnetic material that has a predetermined preferential axis of magnetization. The microdevices are located at specific locations on the arraying substrates and a magnetic field is used to orient the microdevices to facilitate the study of lipids and lipid-associated moieties. The bilayer region can also contain a fluorescent reagent, which can be monitored during exposure to an excitation source. The fluorescent reagent can also be photobleached and monitored for fluorescence recovery.Type: ApplicationFiled: March 21, 2013Publication date: January 15, 2015Applicant: ARRAYOMICS, INC.Inventors: Edward T. Castellana, Bao Nguyen, David Rothwarf
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Patent number: 7723029Abstract: The present invention recognizes that the determination of an ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport functions or properties using microfabricated structures that can allow for automated detection of one or more ion transport functions or properties. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.Type: GrantFiled: June 15, 2005Date of Patent: May 25, 2010Assignee: Aviva Biosciences CorporationInventors: Mingxian Huang, David Rothwarf, Jia Xu, Xiaobo Wang, Lei Wu, Antonio Guia
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Publication number: 20080286750Abstract: The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.Type: ApplicationFiled: August 20, 2007Publication date: November 20, 2008Applicant: Aviva Biosciences CorporationInventors: Jia XU, Antonio Guia, Xiaobo Wang, Lei Wu, Junquan Xu, Mingxian Huang, David Rothwarf
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Publication number: 20080176765Abstract: Particles or other microdevices are disposed in an array having discreet regions (e.g. magnetic bars), oriented within a magnetic field, and then sorted through application of a removing force under conditions that remove a proper subset of the microdevices from the array as a function of differing orientations of the microdevices. Methods are also contemplated for using magnetic patterns to sort collections of microdevices by magnetic complementarity. Preferred methods use a capture and release process to sort microdevices (microdevices), and unlike conventional sorters, do not require high particle flow rates. Also contemplated are microdevice libraries in which microdevices have mutually distinct magnetic codes, and a region with a mutually distinct polymeric or other chemical moiety.Type: ApplicationFiled: January 23, 2008Publication date: July 24, 2008Applicant: Arrayomics, Inc.Inventor: David Rothwarf
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Publication number: 20080176762Abstract: Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.Type: ApplicationFiled: January 23, 2008Publication date: July 24, 2008Applicant: ARRAYOMICS, INC.Inventors: Christopher D. Herold, David Rothwarf, Bao Nguyen
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Publication number: 20070166812Abstract: The present invention provides a novel essential regulatory subunit of the I?B kinase (IKK) complex, IKK-?. The isolated IKK-? subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.Type: ApplicationFiled: March 9, 2007Publication date: July 19, 2007Applicant: The Regents of the University of CaliforniaInventors: Michael Karin, David Rothwarf, Ebrahim Zandi
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Publication number: 20060024732Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.Type: ApplicationFiled: September 20, 2005Publication date: February 2, 2006Inventors: Mingxian Huang, Lei Wu, Xiaobo Wang, Junquan Xu, Guo Liang Tao, David Rothwarf
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Publication number: 20050266478Abstract: The present invention recognizes that the determination of an ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport functions or properties using microfabricated structures that can allow for automated detection of one or more ion transport functions or properties. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.Type: ApplicationFiled: June 15, 2005Publication date: December 1, 2005Inventors: Mingxian Huang, David Rothwarf, Jia Xu, Xiaobo Wang, Lei Wu, Antonio Guia
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Publication number: 20050009004Abstract: The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.Type: ApplicationFiled: January 20, 2004Publication date: January 13, 2005Inventors: Jia Xu, Antonio Guia, Xiaobo Wang, Lei Wu, Junquan Xu, Mingxian Huang, David Rothwarf
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Publication number: 20040146849Abstract: The present invention recognizes that the determination of an ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport functions or properties using microfabricated structures that can allow for automated detection of one or more ion transport functions or properties. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.Type: ApplicationFiled: August 16, 2003Publication date: July 29, 2004Inventors: Mingxian Huang, David Rothwarf, Jia Xu, Xiaobo Wang, Lei Wu, Antonio Guia