Abstract: A microwave generation system comprising a microwave generator, a pulse generator and an impedance network. The pulse generator is arranged to provide pulses of electrical power to the microwave generator and is operable to vary the power of the pulses of electrical power which are provided to the microwave generator. The impedance network is connected between the pulse generator and the microwave generator. The impedance network is switchable so as to substantially match an impedance across the pulse generator according to variations in the impedance of the microwave generator.

Abstract: A magnetron includes a cathode and a cathode supply lead structure connected to the cathode. A connector is included for electrically connecting to the lead structure and adapted for connection to an external power supply. An electrically conductive casing surrounds the connector. Electrically insulating material is included within the casing and surrounds the connector. The insulating material may be potting material.

Abstract: A pill crushing apparatus for use with first and second nestable cups comprising a first cup holder which is moved linearly toward a second cup mounting surface holding a second cup. The first cup holder rotates relative to the rotationally fixed second cup. During the crushing process, the pills first may begin to crush against the linear load being applied thereto, and thereafter grind into a fine powder due to the rotational force of the first cup against the second cup. The first cup and second cup have different sidewall angles to promote pill crushing while inhibiting migration of the crush material to prevent the crushed material from reaching the open gap between the top perimeters of the nesting cups. Each cup includes a plurality of lugs having a curved profile configured to engage respective recesses on the cup holders. Each cup is fabricated through thermoforming or vacuum forming techniques.

Abstract: A pill crushing apparatus for use with first and second nestable cups comprising a first cup holder which is moved linearly toward a second cup mounting surface holding a second cup. The first cup holder rotates relative to the rotationally fixed second cup. During the crushing process, the pills first may begin to crush against the linear load being applied thereto, and thereafter grind into a fine powder due to the rotational force of the first cup against the second cup. The first cup and second cup have different sidewall angles to promote pill crushing while inhibiting migration of the crush material to prevent the crushed material from reaching the open gap between the top perimeters of the nesting cups. Each cup includes a plurality of lugs having a curved profile configured to engage respective recesses on the cup holders. Each cup is fabricated through thermoforming or vacuum forming techniques.

Abstract: The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their pre

Abstract: The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their prepara

Abstract: The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents.

Abstract: The hepatitis B virus (HBV) capsid is made up of a single species of protein called the core antigen (HBcAg) which self-assembles into particles. The particles are highly immunogenic and are able to present heterologous epitopes to the immune system when the epitopes are inserted into a surface-exposed region of the particles called the “e1 loop”. The structural building blocks of the particles are tightly associated dimers of HBcAg in which the adjacent e1 loops are closely juxtaposed. It is proposed that sequences inserted into the e1 loop are conformationally restrained in the assembled particles when presented in monomeric core protein. The invention seeks to solve this problem by covalently linking core proteins as tandem copies (e.g., as dimers) so that insertions can be made independently in each copy.

Abstract: The present invention relates to the use of hepatitis C virus (HCV) p7 protein, and particularly but not exclusively, to its use in rationalised drug design and as a screen for antiviral therapeutic agents.

Abstract: A transgenic non-human animal whose genome comprises a polynucleotide encoding human ICAM-1 domains D1 and D2 and preferably encoding human ICAM-1 domains D1 and D2 and host non-human ICAM-1 domains D3, D4 and D5. Methods for the production of such transgenic animals, screening methods using such transgenic animals, associated transgenes, constructs, vectors, and cells are disclosed. The transgenic non-human animal is a suitable model for studying human rhinovirus infection.

Abstract: The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents.

Abstract: The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents.

Abstract: This invention discloses and claims methods for inhibiting bacterial ?-lactamases and treating bacterial infections by inhibiting bacterial ?-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a ?-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a ?-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.

Abstract: The hepatitis B virus (HBV) capsid is made up of a single species of protein called the core antigen (HBcAg) which self-assembles into particles. The particles are highly immunogenic and are able to present heterologous epitopes to the immune system when the epitopes are inserted into a surface-exposed region of the particles called the “el loop”. The structural building blocks of the particles are tightly associated dimers of HBcAg in which the adjacent el loops are closely juxtaposed. It is proposed that sequences inserted into the el loop are conformationally restrained in the assembled particles when presented in monomeric core protein. The invention seeks to solve this problem by covalently linking core proteins as tandem copies, e.g., as dimers, so that insertions can be made independently in each copy.

Abstract: An exemplary embodiment of the present invention is a flyer bow having a first surface and a second surface in opposition to the first surface. The first and second surfaces are joined to form an airfoil shape. A channel passes through the flyer bow between the first and second surface and a wire guide is disposed within the channel. There is at least one orifice through one of the first and second surface thereby establishing fluid communication between the channel and the ambient atmosphere.

Abstract: A method and apparatus for configuring a software application on a cluster is provided. A configuration coordinator executing on a configuration manager communicates with one or more configuration slaves executing on a set of nodes that are operating as a cluster. The configuration coordinator sends messages to the one or more configuration slaves to initiate a configuration operation for a software application. Each configuration slave automatically performs a series of actions to configure the node on which it resides. When all the nodes complete the configuration operation for the software, the process is complete. While performing the series of actions, the configuration slaves generate logs that reflect their progress in performing the series of actions. If a problem occurs during performance of the series of actions, the configuration slave that encounters the problem indicates to the configuration coordinator that an error occurred.