Abstract: A method of treating vitiligo, including prophylaxis, in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a compound of Formula (I): wherein: X is CR1 or N; Y is CH, C or N; R1 is hydrogen, C1-6alkoxy or C1-6alkyl; R2 is hydrogen, C1-6alkoxy, halo, —C(O)C1-6alkyl, CN, halo-C1-6alkyl or —C(O)NR4R5; R3 is hydrogen or C1-6alkoxy; R4 is hydrogen or C1-6alkyl: R5 is hydrogen or C1-6alkyl; and m and n are integers each independently selected from 1 and 2, or a pharmaceutically acceptable salt thereof.

Abstract: The presently disclosed subject matter provides compounds, compositions, and methods for targeting UDP-N-acetylglucosamine polypeptide ?-N-acetylglucosaminyl transferase (OGT). Further, the presently disclosed subject matter provides compounds, compositions, and methods for promoting wound healing.

Abstract: A system and method for integrating clinical trial data housed in disparate systems. The integration system listens for a clinical trial event broadcasted by any one of the disparate systems. The clinical trial events are the same or similarly defined among the disparate systems. The integration system receives notice of a clinical trial event from one of the disparate systems and then sends a query to the disparate systems requesting metadata corresponding with the clinical trial event. The metadata is comprised of attributes of the clinical trial event and the values of such metadata may differ among the disparate systems. The responsive metadata is stored in an unstructured format and can be displayed in substantially real-time via a graphical user interface.

Abstract: A computerized system for oil field applications. The computerized system may include an oilfield application and an oilfield application development kit that provides a software architecture for developing one or more plug-in components that may be executable by the oilfield application. The computerized system may also include an online distribution center that facilitates access to the plug-in components.

Abstract: A big data database managed by a procurement service aggregates purchase data received from federal, state and local government agencies through Freedom of Information Act requests, state public records requests and private sector business entities. An automated system processes a vast amount of purchase data files acquired from numerous different agencies through a number of different transports, on a variety of different media, included within several different file formats. A best match is selected for each acquired file with one of a multitude of configuration files available to process the purchase files. The file is then processed with the selected configuration file and aggregated into the database. The database is then made available to customers of the procurement service for search, reports and analysis purposes.

Abstract: A big data database managed by a procurement service aggregates purchase data received from federal, state and local government agencies through Freedom of Information Act requests, state public records requests and private sector business entities. An automated system processes a vast amount of purchase data files acquired from numerous different agencies through a number of different transports, on a variety of different media, included within several different file formats. A best match is selected for each acquired file with one of a multitude of configuration files available to process the purchase files. The file is then processed with the selected configuration file and aggregated into the database. The database is then made available to customers of the procurement service for search, reports and analysis purposes.

Abstract: A computerized system for oil field applications. The computerized system may include an oilfield application and an oilfield application development kit that provides a software architecture for developing one or more plug-in components that may be executable by the oilfield application. The computerized system may also include an online distribution center that facilitates access to the plug-in components.

Abstract: Methods and apparatus to route communications at an interexchange carrier are disclosed. One method of routing communications may include receiving a communication at the interexchange carrier, determining a destination at which the communication is to terminate, and routing the communication from the interexchange carrier through a terminating access charge free line to a terminating mobile telephone switching office.

Abstract: A system for, and method of, blending (or integrating) pseudo-range or position measurements and bearing-to-transmitter measurements from an eLORAN or LORAN-C receiver and position (alternatively, pseudo ranges) and velocity (alternatively pseudo-range rate) measurements from a GPS receiver. The described system can also be integrated with additional external positioning systems. In the context of an inertial navigation system (INS) application, this combined GPS/LORAN signal can be employed to provide external positioning solutions, potentially integrated with measurements from devises such as accelerometers, gyroscopes, altimeters, etc. The system includes a GPS signal input, a LORAN signal input, preprocessors for each, and an integrator to combine the two preprocessed signals to estimate errors in the full trajectory variables.

Abstract: Methods and apparatus to route communications at an interexchange carrier are disclosed. One method of routing communications may include receiving a communication at the interexchange carrier, determining a destination at which the communication is to terminate, and routing the communication from the interexchange carrier through a terminating access charge free line to a terminating mobile telephone switching office.

Abstract: Methods and apparatus to route communications at an interexchange carrier are disclosed. One method of routing communications may include receiving a communication at the interexchange carrier, determining a destination at which the communication is to terminate, and routing the communication from the interexchange carrier through a terminating access charge free line to a terminating mobile telephone switching office.

Abstract: A method for treatment of compressed fascial tissues on the human body comprising a two part process. The first part comprises a treatment of fascial tissues around the cranium and the second part comprises a treatment of fascial tissues along the torso and limbs. The first part administers a method of palpation to tactilely identify areas of compressed fascial tissue and treats identified areas using compressive and tractional forces applied to the area perpendicularly to one another until compression is released. The second part includes a sequences of stretching postures that elongate the tissues in the torso and limbs further relieving the body of compressed tissues. The second part is aided by use of an orientation device that provides reference points for commencement of a stretching posture and for directing movement thereafter. A platform device is also included for promoting a stretching posture and a balancing aid is provided for supporting the weight of the torso during select exercises.

Abstract: Assessing a patient to select an articulated body part to be calibrated and repeatedly moving the body part slowly back and forth through a selected path while yielding applying a low level restrictive force to movement in at least one direction along the path.

Abstract: An introducer for use with an ultrasonic imaging system. The introducer comprises a tubular member having a connecting end, a positioning end, and a central lumen, the connecting end including a coupling for attaching the introducer to an ultrasonic imaging system, and the positioning end comprising a plug or other structure that facilitates positioning of the introducer inside a urethra at a fixed anatomical landmark.

Abstract: An ultrasound scanning system and methods of using the same. In one preferred form, an ultrasound scanning system comprises an acoustic imaging catheter comprising an ultrasonic transducer, a motion control system and an imaging computer system for imaging a patient's genitourinary system. In another preferred form, an ultrasound scanning system is used for imaging a patient's prostate gland.

Abstract: Methods and apparatus to route communications at an interexchange carrier are disclosed. One method of routing communications may include receiving a communication at the interexchange carrier, determining a destination at which the communication is to terminate, and routing the communication from the interexchange carrier through a terminating access charge free line to a terminating mobile telephone switching office.