Abstract: A method for creating optical articles includes moving first and second mold portions relative to one another. This disclosure includes injection molds for reducing cycle times and related methods. Some molds include first and second mold portions movable relative to one another from open to closed positions in which each recess of the first mold portion cooperates with a respective recess of the second mold portion to define a chamber. Each chambers includes a first cooling body coupled to the first mold portion, a second cooling body coupled to the second mold portion, and first and second inserts removably coupled, respectively, to the first and second cooling bodies. The inserts cooperate to define a mold cavity within the chamber configured to receive a thermoplastic material. Each of the cooling bodies has an inlet, an outlet, and a fluid cavity in fluid communication with the inlet and the outlet.

Abstract: This disclosure includes injection molds for reducing cycle times and related methods. Some molds include first and second mold portions movable relative to one another from an open position to a closed position in which each of one or more recesses of the first mold portion cooperates with a respective one of one or more recesses of the second mold portion to define a chamber. Each of the chamber(s) includes a first cooling body coupled to the first mold portion, a second cooling body coupled to the second mold portion, and first and second inserts removably coupled, respectively, to the first and second cooling bodies such that the inserts cooperate to define a mold cavity within the chamber that is configured to receive a thermoplastic material. Each of the cooling bodies has an inlet, an outlet, and a fluid cavity in fluid communication with the inlet and the outlet.

Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.