Abstract: A salve includes a water-miscible, hydrophilic cream vehicle, 1-22% by weight a-DFMO, and no absorption enhancer. The salve is preferably contained in an ointment tube permanently sealed at one end to preclude exposure to light and air. The salve is applied as a preventative in an appropriate amount twice daily to skin exposed to actinic radiation. An initial application of a salve including 10% by weight A-DFMO is preferred to minimize the risk of skin irritation without compromising the therapeutic value of the salve. The salve shows no systemic uptake, thereby eliminating systemic toxicities that result from other techniques for administering the drug.

Abstract: Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.

Abstract: This invention relates to a compound useful for the treatment of tumors having the formula: ##STR1##

Abstract: New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases.Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

Abstract: A connector backshell assembly for wires or coaxial cables is provided in which a body and a cover define a housing therefor. An internal support member is mounted within the housing in the form of a split support which secures the wires or cables therebetween. A connector is mounted to the housing at the forward end thereof, which connector electrically engages the wires or coaxial cables. An exit clamp member mounted to such body proximate the aft end thereof, which defines a wide exit window, is provided for further securing such wires or coaxial cables as they exit the housing to thus provide double conductive member support and strain relief where such conductive members engage the connector e.g. when the conductive member or members are bent or twisted relative to the connector backshell assembly.

Abstract: A needle assembly comprises a needle having a sharp point encased within and movable with respect to a sheath having a blunt end. A hub attached to the sheath has a recess therein for receiving a compressible member carried by an end of the needle having a collar thereon for engaging the compressible member. The compressible member retracts the point of the needle into the interior of the sheath to prevent contact of the point by user of the needle. When the needle assembly is attached to a syringe, or other instrument, the collar of the needle is engaged by a portion of the syringe and moved to compress the compressible member and expose the point of the needle for use.

Abstract: An aspiration device for delivering a controlled dosage of a drug to a smoker's mouth and lungs comprises an elongated container adapted to be positioned within a cigarette or other smoking article adjacent the end intended to be held in the smoker's mouth. The container holds a supply of a drug which is aspirated directly into the smoker's mouth as a result of the suction applied by the smoker to the end of the cigarette. An air inlet port communicates with the outer surface of the cigarette and permits air to enter the container in response to the partial vacuum created by the applied suction. The drug held within the container is discharged through an exit orifice thereof which is coplanar with the end of the cigarette, so that mixing of the drug with the tobacco smoke occurs within the mouth of the smoker, at reduced temperature and lower smoke concentration.