Patents by Inventor David S. Bredt

David S. Bredt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPRESSION SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20200362013
    Abstract: Expression systems for the expression of an ?9?10 nicotinic acetylcholine receptor (nAChR) are described. Also described are methods of using the expression systems to identify agonists, antagonists, or allosteric modulators of an ?9?10 nAChR.
    Type: Application
    Filed: May 15, 2020
    Publication date: November 19, 2020
    Inventors: David S. Bredt, Weston Davini, Shenyan Gu, Jose Matta, Min Lei O'Carroll
  • Treatments for male sexual dysfunction
    Patent number: 5439938
    Abstract: Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: August 8, 1995
    Assignee: The Johns Hopkins University
    Inventors: Solomon H. Snyder, Arthur L. Burnett, Charles J. Lowenstein, David S. Bredt, Thomas S. K. Chang
  • Purification and molecular cloning of nitric oxide synthase
    Patent number: 5268465
    Abstract: A method of purifying calmodulin-dependent nitric oxide synthase provides a homogeneous preparation of the enzyme. The enzyme is used to raise antibodies which are a useful immunohistochemical reagent. The antibodies localize calmodulin-dependent nitric oxide synthase to a number of anatomical sites, including retina, intestine, adrenal gland, and vasculature. However, activated macrophages, which are known to possess a nitric oxide producing activity, do not display an immunoreactive protein of appropriate size on Western blots using the antibodies. Nucleotide sequences encoding calmodulin-dependent nitric oxide synthase indicate a novel sequence with a flavin binding site consensus sequence.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: December 7, 1993
    Assignee: The Johns Hopkins University
    Inventors: David S. Bredt, Solomon H. Snyder
  • Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity
    Patent number: 5266594
    Abstract: Inhibitors of nitric acid synthase can be used to prevent neurotoxicity mediated through glutamate receptors. Nitric oxide synthase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease and Huntington's disease.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: November 30, 1993
    Inventors: Valina L. Dawson, Ted M. Dawson, Edythe D. London, David S. Bredt, Solomon H. Snyder