Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: A beater for a mixer includes a shaft including a mixer attachment portion, the shaft defining a rotational axis of the beater. A first stabilizing arm extends outwardly from the shaft and a second stabilizing arm extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: A beater for a mixer includes a shaft including a mixer attachment portion, the shaft defining a rotational axis of the beater. A first stabilizing arm extends outwardly from the shaft and a second stabilizing arm extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.

Abstract: A beater for a mixer includes a shaft (14) including a mixer attachment portion (16), the shaft defining a rotational axis (A) of the beater. A first stabilizing arm (18) extends outwardly from the shaft and a second stabilizing arm (20) extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade (22) has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face (40) that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade (24) has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face (42) that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: A beater for a mixer includes a shaft (14) including a mixer attachment portion (16), the shaft defining a rotational axis (A) of the beater. A first stabilizing arm (18) extends outwardly from the shaft and a second stabilizing arm (20) extends outwardly from the shaft and spaced circumferentially from the first stabilizing arm. A first blade (22) has an upper end connected to the first stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face (40) that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end. A second blade (24) has an upper end connected to the second stabilizing arm at a location spaced from the shaft, a lower end located proximate the rotational axis of the beater and a leading face (42) that transitions from a substantially vertical orientation at the lower end to a downwardly angled orientation at the upper end.

Abstract: A pneumatic bioreactor having a containment vessel which includes a semi-cylindrical concavity defined by the vessel bottom. A mixing apparatus includes a rotational mixer rotatably mounted within the containment vessel about a horizontal axis. The rotational mixer has buoyancy-driven mixing cavities which are fed by a gas supply beneath the rotational mixer. The mixing apparatus extends into the semi-cylindrical concavity to substantially fill that concavity. The rotational mixer is divided into two wheels with outer paddles extending axially outwardly and inner paddles extending axially inwardly on either side of each ring. Blades between the outer and inner paddles form impellers in the wheels to induce axial flow through the rings in opposite directions. The containment vessel may be of film and supported by a structural housing also having a semi-cylindrical concavity defined by the housing bottom.