Abstract: A fully implantable intracorporeal blood purifier for patients with impaired, missing, or normal kidneys overwhelmed by a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia, primary myelofibrosis, or chronic myelogenous leukemia. Functioning continuously or intermittently around the clock, the patient is spared the need to visit the clinic as frequently for treatment, and less severe renal dysfunction may allow the intervals between visits to be considerably extended if not eliminated.

Abstract: Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Abstract: Described are surgical hand tools to facilitate the proper implantation beneath the outer layer of ductus to include vessels, the trachea, esophagus, and ureters, as well as glands, organs, or other tissue of medicinal, magnetically susceptible, magnetized, and/or radiation-emitting stays, or ribs—arcuate bands sized in proportion to the substrate structure which incorporate substances for implantation toward the surface of the substrate. Stay insertion tools allow access to and expedite stay insertion into deeper tissue through a small, or ‘keyhole’ incision at the body surface, eliminating the need for more extensive incision, reducing procedural duration, and can coat each stay with medication and/or an adhesive as each is ejected. Susceptible and magnetized stays allow extraluminal stenting, which avoids the lumen, allowing the in situ treatment of a ductus which malacotic, infected, or otherwise diseased, would likely incur incisions, perforations, and/or abrasions during transluminal treatment.

Abstract: Described are surgical tools to facilitate the proper implantation beneath the outer layer of tubular anatomical structures, or ductus, to include vessels, the trachea, esophagus, gut, and ureters, as well as the outer layer or within the parenchyma of organs, glands, or other tissue, of medicinal, magnetically susceptible, magnetized, and/or radiation-emitting spherules sized in proportion to the substrate structure. Spherule insertion tools expedite insertion transluminally to implant the wall surrounding a lumen making possible therapy and/or extraluminal stenting which leaves the lumen clear for subsequent passage. Spherules can also be introduced into deeper tissue through a ‘keyhole’ incision at the body surface. For evolving methods calling for the placement of numerous ‘seeds’ and/or boluses, eliminated are the need for more extensive incision with increased trauma, procedural duration, and healing time.

Abstract: Set forth are the structure, function, placement, and applications of vascular valves and servovalves. In the vascular tree, the diversion, shunting, and bypass of flow these provide allow solid organ transplantation which eliminates anoxia and graft organ degradation following harvesting and storage, likely including late term cardiac allograft vasculopathy. Along the lower urinary tract, the diversion of urine from damaged ureters to the native or an artificial bladder or collection bag alleviates problems of intractable urinary incontinence, nocturia, overactive bladder, and frequent urination. Where the lower tract is missing, the synthetics in a valve-based prosthesis preclude infection and degenerative metaplastic transition which can result in malignancy when gut is used to construct a neobladder and/or high maintenance stoma. Accessory channels in side-entry valves and servovalves allow the direct pipe-targeting of medication to sites of disease, anastomoses, or any other trouble spots.

Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

Abstract: A fully implanted automatic disorder response system acts as a backup “immune” system, immediately detecting and dispensing an enzyme deficient or lacking due to an inborn error of metabolism, for example, in accordance with its prescription-program. In response to a disease, the remedial action is usually medicinal and/or electrostimulatory. By directly pipeline-targeting agents through pipelines from implanted reservoirs to leak-free and durable tissue connectors at the focal points of chronic disease, the system avoids the dispersion of drugs throughout the circulation and the side effects this causes, fundamentally liberalizing while optimizing the use of drugs. Electrostimulatory and other end-effectors available, each morbidity or site thereof in comorbid disease is assigned to an arm or channel of an hierarchical control system.

Abstract: A fully implanted automatic disorder response system is devised to act as a backup “immune” system, automatically detecting and dispensing an enzyme, for example, deficient due to an inborn error of metabolism. In response to a disease, the agent released is one or more drugs. By directly pipeline-targeting agents through a closed system of drug reservoirs, fluid and electrical lines, and leak-free, durable, and safe tissue connectors to the site of disease, the system achieves a level of efficiency critically superior to the systemic dispersal of an agent into the circulation, fundamentally liberalizing the use of drugs. In comorbid disease, each morbidity is assigned to an arm or channel in a hierarchical control system. Beginning with symptomatic indicia sensors, data is analyzed and passed up through successively higher-level nodes that generate a cross-morbidity view passed up to an implanted microprocessor which effectuates a release of drugs calculated to optimize homeostasis.

Abstract: A fully implanted automatic disorder response control system acts as a backup “immune” system, immediately detecting and dispensing an enzyme deficient or lacking due to an inborn error of metabolism, for example, in accordance with its prescription-program. In response to a disease, the remedial action is medicinal and/or electrostimulatory. By directly pipeline-targeting agents through a closed system of fluid lines from drug reservoirs to leak-free and durable tissue connectors at the sites of disease, the system averts side effects without dispersing an agent throughout the systemic circulation, fundamentally liberalizing, while optimizing, the use of drugs. Electrostimulatory and other end-effectors available, each morbidity in comorbid disease is assigned to an arm or channel of a hierarchical control system.

Abstract: Provided is a connector suitable for securely infixing a catheter, electrode, hollow needle, probe, or other styliform device with its tip stabilized within a nontubular anatomical structure. Secure junctions between fluid lines and/or electrodes and tissue are essential for automatic controls and permanent nephrostomies and suprapubic cystostomies, for example, using synthetic materials. These can be made self-contained and fully implanted to treat one chronic condition, or represent but one module controlled as an axis or channel of control in an adaptive ambulatory hierarchical prosthetic disorder response system used to automatically coordinate the treatment of chronic comorbid disease. Such applications require prosthesis-to-native tissue junctions which are secure, immobile, unsusceptible to leaks or microbial intrusion, and require little if any maintenance. Connection for securely and least disruptively merging catheteric and native lumina is described in nonprovisional application Ser. No.

Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

Abstract: Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

Abstract: Provided is a connector suitable for securely infixing a catheter, electrode, hollow needle, probe, or other styliform device with its tip stabilized within a nontubular anatomical structure. Secure junctions between fluid lines and/or electrodes and tissue are essential for automatic controls and permanent nephrostomies and suprapubic cystostomies, for example, using synthetic materials. These can be made self-contained and fully implanted to treat one chronic condition, or represent but one module controlled as an axis or channel of control in an adaptive ambulatory hierarchical prosthetic disorder response system used to automatically coordinate the treatment of chronic comorbid disease. Such applications require prosthesis-to-native tissue junctions which are secure, immobile, unsusceptible to leaks or microbial intrusion, and require little if any maintenance. Connection for securely and least disruptively merging catheteric and native lumina is described in nonprovisional application Ser. No.

Abstract: Provided are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the carrier particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to paragraph [0004].

Abstract: Provided are methods and apparatus for the use of magnetic traction to maintain the patency of a tubular anatomical structure, whether a vessel, duct, the trachea, bronchus, bile duct, ureter, vas deferens, fallopian tube, or portions of the digestive tract, as to constitute means for extraluminal stenting. An extraluminal stent consists of a perimedial or medial intravascular and an extravascular component. The intravascular component consists of ferromagnetic spherules implanted aeroballistically or stays implanted by means of a special hand tool, while the extravascular component consists of a pliant jacket or mantle that has magnets mounted about its outer surface.

Abstract: A vehicle traction device adapted to provide a traction base for a drive wheel of an automotive vehicle, comprising in combination, a length of cylindrical pipe stock, metal washers space and fastened at intervals along the length of this pipe stock in surrounding relation thereto, end portions of metal angle stock, the pipe stock intersecting with this angle stock generally at the convex surface centers and with the pipe and angle stock major axes at right angles to one another, these components being welded together so as to constitute a unitized whole.

Abstract: This invention relates to a foot-operated Bowden type cable mechanism which is operatively associated with a padded damping plate whose incidence with the underside of a timpano membrane, for example, terminates its vibration. If the device of the invention is actuated prior to the delivery of an exciting blow, operation is as a muffler or mute.In an alternate embodiment, an electromechanical actuator is mounted so as to allow the silent and hand-free muffling or silencing of a timpano. Typically, the actuator is a direct current energized solenoid mounted internally to the drum. This solenoid is of the push type, the magnetically nonsusceptible plunger-extension being directed upwards and conveying to the underside of the timpano membrane the camping plate with overlying padding whose incidence with the membrane mutes or terminates its vibration. A foot switch permits hands-free operation.