Abstract: Systems, methods, computer readable media, and devices for managing a manufacturing supply chain to ensure compliance with industry-specific and federal standards from the time the material is supplied by a vender to the time a product is provided to a customer. In some embodiments, a system for managing a supply chain includes a variety of databases (e.g., a customer database, a vendor database, a risk management database, a validation database, etc.). The databases store information associated with material vendors, customers, risk assessments, control parameters, and validation or qualification information related to the use of machines and manufacturing processes. This information is used to process a purchase order and ensure that a customer receives a corresponding quote fulfilling the order and including materials that are in compliance with the customer's own manufacturing and materials standards, as well as any relevant federal and industry-specific standards.