Patents by Inventor David S. HERBST

David S. HERBST has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen
    Patent number: 11906521
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: February 20, 2024
    Assignee: LONZA WALKERSVILLE, INC.
    Inventors: Candice Stumbaugh, David S. Herbst, Kenneth E. Nichols, Jr.
  • METHOD OF DETECTING AN ENDOTOXIN USING LIMULUS AMEBOCYTE LYSATE SUBSTANTIALLY FREE OF COAGULOGEN
    Publication number: 20220074940
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 10, 2022
    Inventors: Candice STUMBAUGH, David S. HERBST, Kenneth E. NICHOLS, JR.
  • Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen
    Patent number: 11156614
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: October 26, 2021
    Assignee: Lonza Walkersville, Inc.
    Inventors: Candice Stumbaugh, David S. Herbst, Kenneth E. Nichols, Jr.
  • Method of Detecting an Endotoxin Using Limulus Amebocyte Lysate Substantially Free of Coagulogen
    Publication number: 20180038864
    Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.
    Type: Application
    Filed: August 3, 2017
    Publication date: February 8, 2018
    Applicant: Lonza Walkersville, Inc.
    Inventors: Candice Stumbaugh, David S. HERBST, Kenneth E. NICHOLS, JR.