Patents by Inventor David S. MILLAN

David S. MILLAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN
    Publication number: 20180370933
    Abstract: The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Kenneth W. Bair, David R. Lancia, JR., Hongbin Li, James Loch, Wei Lu, Matthew W. Martin, David S. Millan, Shawn E.R. Schiller, Mark J. Tebbe
  • BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20180312524
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 1, 2018
    Inventors: Kenneth W. Bair, Torsten Herbertz, Goss S. Kauffman, Katherine J. Kayser-Bricker, George P. Luke, Matthew W. Martin, David S. Millan, Shawn E.R. Schiller, Adam C. Talbot, Mark J. Tebbe
  • 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
    Patent number: 10112915
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: October 30, 2018
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
  • TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20180215766
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 2, 2018
    Inventors: Kenneth W. Bair, Torsten Herbertz, Goss S. Kauffman, Katherine J. Kayser-Bricker, George P. Luke, Matthew W. Martin, David S. Millan, Shawn E.R. Schiller, Adam C. Talbot
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN
    Publication number: 20180050997
    Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 22, 2018
    Inventors: Kenneth W. Bair, David R. Lancia, JR., Hongbin Li, James Loch, Wei Lu, Matthew W. Martin, David S. Millan, Shawn E.R. Schiller, Mark J. Tebbe
  • METHODS OF USING FASN INHIBITORS
    Publication number: 20170312273
    Abstract: The present disclosure relates to methods of treating, preventing or ameliorating a TH17- or CSF1-mediated disease or disorder such as cancer, immunological disorders, and obesity by administering to a patient in need thereof a therapeutically effective amount of a FASN inhibitor, or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof.
    Type: Application
    Filed: April 25, 2017
    Publication date: November 2, 2017
    Inventors: David S. Millan, Wei Lu
  • 3-spiro-7-hydroxamic acid tetralins as HDAC inhibitors
    Patent number: 9630922
    Abstract: The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 25, 2017
    Assignee: Forma Therapeutics, Inc.
    Inventors: Pui Yee Ng, Heather Davis, Kenneth W. Bair, David S. Millan, Aleksandra Rudnitskaya, Xiaozhang Zheng, Bingsong Han, Nicholas Barczak, David R. Lancia, Jr.
  • 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS
    Publication number: 20160304462
    Abstract: The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.
    Type: Application
    Filed: April 15, 2016
    Publication date: October 20, 2016
    Inventors: Pui Yee Ng, Heather Davis, Kenneth W. Bair, David S. Millan, Aleksandra Rudnitskaya, Xiaozhang Zheng, Bingsong Han, Nicholas Barczak, David R. Lancia, JR.
  • BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20160256458
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
    Type: Application
    Filed: May 12, 2016
    Publication date: September 8, 2016
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT, Mark J. TEBBE
  • BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20160257699
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
    Type: Application
    Filed: May 12, 2016
    Publication date: September 8, 2016
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT, Mark J. TEBBE
  • TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20160256448
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
    Type: Application
    Filed: May 12, 2016
    Publication date: September 8, 2016
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT
  • TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20160257692
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
    Type: Application
    Filed: May 12, 2016
    Publication date: September 8, 2016
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT
  • Benzopiperazine compositions as BET bromodomain inhibitors
    Patent number: 9422281
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) br’omodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: August 23, 2016
    Assignee: Forma Therapeutics, Inc.
    Inventors: Kenneth W. Bair, Torsten Herbertz, Goss S. Kauffman, Katherine J. Kayser-Bricker, George P. Luke, Matthew W. Martin, David S. Millan, Shawn E. R. Schiller, Adam C. Talbot, Mark J. Tebbe
  • 3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20160222022
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Heather Davis, Aleksandra Rudnitskaya, David Lancia, JR., David S. Millan, Matthew W. Martin
  • 3-ARYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20160221973
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David Lancia, JR., David S. Millan, Matthew W. Martin
  • 3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20160222028
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Heather Davis, Aleksandra Rudnitskaya, David Lancia, JR., Kenneth W. Bair, David S. Millan, Matthew W. Martin
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20160221972
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • Tetrahydroquinoline compositions as BET bromodomain inhibitors
    Patent number: 9388161
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: July 12, 2016
    Assignee: Forma Therapeutics, Inc.
    Inventors: Kenneth W. Bair, Torsten Herbertz, Goss S. Kauffman, Katherine J. Kayser-Bricker, George P. Luke, Matthew W. Martin, David S. Millan, Shawn E. R. Schiller, Adam C. Talbot
  • BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20150232465
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
    Type: Application
    Filed: November 18, 2014
    Publication date: August 20, 2015
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT, Mark J. TEBBE
  • TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
    Publication number: 20150232445
    Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
    Type: Application
    Filed: November 18, 2014
    Publication date: August 20, 2015
    Inventors: Kenneth W. BAIR, Torsten HERBERTZ, Goss S. KAUFFMAN, Katherine J. KAYSER-BRICKER, George P. LUKE, Matthew W. MARTIN, David S. MILLAN, Shawn E.R. SCHILLER, Adam C. TALBOT