Abstract: Consistent with the present disclosure, an encoder circuit is provided at a transmit side of an optical fiber link that maps an input sequence of bits of fixed length k to a sequence of symbols of a codeword of length n, such that the symbols of the codeword define a predetermined transmission probability distribution. In one example, each subgroup of bits of the k input bit sequence is provided to a respective look-up table, whereby the sub-group of bits constitutes an address of a particular memory location in the corresponding look-up table. Based on the address, the contents at the particular memory location addressed by each subgroup of bits are output as a corresponding portion of a codeword. Each such codeword portion is provided to a further memory or buffer, such that the entire codeword is assembled in the buffer and output to forward error correction (FEC) circuitry.

Abstract: Consistent with the present disclosure, an encoder circuit is provided at a transmit side of an optical fiber link that maps an input sequence of bits of fixed length k to a sequence of symbols of a codeword of length n, such that the symbols of the codeword define a predetermined transmission probability distribution. In one example, each subgroup of bits of the k input bit sequence is provided to a respective look-up table, whereby the sub-group of bits constitutes an address of a particular memory location in the corresponding look-up table. Based on the address, the contents at the particular memory location addressed by each subgroup of bits are output as a corresponding portion of a codeword. Each such codeword portion is provided to a further memory or buffer, such that the entire codeword is assembled in the buffer and output to forward error correction (FEC) circuitry.

Abstract: A method modulates data for optical communication by first encoding the data using a forward error correction (FEC) encoder to produce encoded data, which are encoded using a block encoder to produce block encoded data such that Lee distances between code words that represent the block encoded data are increased. The block encoded data are mapped to produce mapped data such that Euclidian distances between the constellation points are increased. Then, the mapped data are modulated in a transmitter to a modulated signal for an optical channel.

Abstract: A method modulates data for optical communication by first encoding the data using a forward error correction (FEC) encoder to produce encoded data, which are encoded using a block encoder to produce block encoded data such that Lee distances between code words that represent the block encoded data are increased. The block encoded data are mapped to produce mapped data such that Euclidian distances between the constellation points are increased. Then, the mapped data are modulated in a transmitter to a modulated signal for an optical channel.

Abstract: A detection method for detecting a variation in GH1 effective to act as an indicator of GH dysfunction in an individual, comprises the steps of comparing a test sample comprising a nucleotide sequence of the human GH1 gene from the individual with a standard sequence known to be that of the human GH1 gene. A difference between the test sample sequence and the standard sequence indicates the presence of a variation effective to act as an indicator of GH dysfunction (hereinafter “variant of GH1”).

Abstract: A detection method for detecting a variation in GH1 effective to act as an indicator of GH dysfunction in an individual, comprises the steps of comparing a test sample comprising a nucleotide sequence of the human GH1 gene from the individual with a standard sequence known to be that of the human GH1 gene. A difference between the test sample sequence and the standard sequence indicates the presence of a variation effective to act as an indicator of GH dysfunction (hereinafter “variant of GH1”).