Patents by Inventor David S. Perlin

David S. Perlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10385409
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: August 20, 2019
    Assignee: Rutgers, the State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20180256673
    Abstract: The disclosure relates to methods of treating a fungal infection in a subject by administering to the subject a salt of Compound 1, or a neutral form thereof. The methods of the disclosure can be useful in subjects suffering from treatment resistant infections, useful in subjects who have previously failed treatment with an anti-fungal therapy, and useful for suppressing the emergence of resistant strains in infected subjects.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Inventors: James Michael BALKOVEC, Kenneth BARTIZAL, Jeffrey Brian LOCKE, Voon ONG, Taylor SANDISON, Dirk THYE, David S. PERLIN, Kenneth Duke JAMES, Jr.
  • Publication number: 20180002766
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: May 22, 2017
    Publication date: January 4, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20170356034
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicants: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Patent number: 9700638
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 11, 2017
    Assignees: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Patent number: 9657334
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 23, 2017
    Assignees: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Patent number: 9657355
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: May 23, 2017
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Steven Park, David S. Perlin, David Wemyss Denning
  • Publication number: 20160106867
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Application
    Filed: May 8, 2014
    Publication date: April 21, 2016
    Applicants: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Publication number: 20150125856
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: June 16, 2014
    Publication date: May 7, 2015
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20150098905
    Abstract: The present invention relates to targeting agents and methods: of using the targeting agents to detect a fungal cell in a subject.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 9, 2015
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Guillermo Garcia-Effron, Arkady Mustaev
  • Patent number: 8753819
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: June 17, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20110091872
    Abstract: Methods are provided for detecting triazole -resistant fungi in a sample. The methods comprise evaluating the sample for the presence of a gene encoding a mutant AzRF1 transcription factor, or the level of the transcription factor, to determine whether a fungus is triazole-resistant. Primers, probes and kits also are provided.
    Type: Application
    Filed: May 2, 2008
    Publication date: April 21, 2011
    Inventors: Eleusa Maria F. Rocha, Steven Park, David S. Perlin
  • Publication number: 20100221710
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: November 1, 2007
    Publication date: September 2, 2010
    Inventors: Steven Park, David S. Perlin, David Wemyss Denning
  • Publication number: 20100075302
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: July 26, 2006
    Publication date: March 25, 2010
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, MERCK & CO.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly