Patents by Inventor David S. Perlin

David S. Perlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240191313
    Abstract: A method, detection assay, and kit for rapidly detecting mutations of the SARS-COV-2 virus includes preparing a detection assay, performing an asymmetric real time-polymerase chain reaction (RT-PCR) on the detection assay using a Mic Real Time PCR cycler, and analyzing a melting curve to detect peaks at a 484 and a 501 codon of a gene, or detect peaks at a 452 codon and a 478 codon of a gene. The method, detection assay, and kit also provides for detecting of the SARS-COV-2 virus and mutations thereof. Disclosed is a high-throughput test that can detect multiple variants of the SARS-COV-2 virus within two-and-a-half hours, and is a major advance in tracking the virus and in treating patients. The test can detect UK, Brazil, South African, and Omicron variants, as well as others containing, for example, a key E484K mutation, which are gaining prominence as the virus evolves.
    Type: Application
    Filed: April 6, 2022
    Publication date: June 13, 2024
    Applicant: Hackensack Meridian Health, Inc.
    Inventors: Yanan Zhao, Liang Chen, David S. Perlin
  • Publication number: 20240158875
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: January 25, 2024
    Publication date: May 16, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Steven Park, David S. Perlin
  • Publication number: 20240158874
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: January 24, 2024
    Publication date: May 16, 2024
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Steven Park, David S. Perlin, David W. Denning
  • Patent number: 11884985
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: January 30, 2024
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20220136072
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 5, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Patent number: 11279936
    Abstract: Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: March 22, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: David S. Perlin, Gregory R. Weidman, Yanan Zhao
  • Patent number: 11230742
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: January 25, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20210277488
    Abstract: A detection panel for the universal detection of SARS-like coronaviruses and SARS-CoV-2 viruses and a method for using the detection panel are provided. The detection panel may be known as a Center for Discovery and Innovation (“CDI”) detection panel (CDI Enhanced COVID-19 Test) and may also include an additional primer/probe set in the detection panel to detect the human RNase P gene (RP) in control samples and clinical specimens. The detection panel is designed for both universal detection of SARS-like coronaviruses using an E gene (envelope) detection assay, and specific detection of the SARS-CoV-2, using an N2 (nucleocapsid) detection assay.
    Type: Application
    Filed: November 20, 2020
    Publication date: September 9, 2021
    Applicant: Hackensack Meridian Health, Inc.
    Inventors: Yanan Zhao, David S. Perlin, Steven Park
  • Patent number: 10934577
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 2, 2021
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, MERCK & CO., INC.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20200248182
    Abstract: Aptamers having a G-quadruplex structure that bind specifically to the most commonly used azole-class antifungal drugs, biosensors that comprise those aptamers, and invitro methods for determining the level of one of those drugs utilizing those aptamers or biosensors.
    Type: Application
    Filed: August 1, 2018
    Publication date: August 6, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Gregory R. Weidman, Yanan Zhao
  • Publication number: 20200149119
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: August 16, 2019
    Publication date: May 14, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Patent number: 10385409
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: August 20, 2019
    Assignee: Rutgers, the State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20180256673
    Abstract: The disclosure relates to methods of treating a fungal infection in a subject by administering to the subject a salt of Compound 1, or a neutral form thereof. The methods of the disclosure can be useful in subjects suffering from treatment resistant infections, useful in subjects who have previously failed treatment with an anti-fungal therapy, and useful for suppressing the emergence of resistant strains in infected subjects.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Inventors: James Michael BALKOVEC, Kenneth BARTIZAL, Jeffrey Brian LOCKE, Voon ONG, Taylor SANDISON, Dirk THYE, David S. PERLIN, Kenneth Duke JAMES, Jr.
  • Publication number: 20180002766
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Application
    Filed: May 22, 2017
    Publication date: January 4, 2018
    Applicant: Rutgers, The State University of New Jersey
    Inventors: David S. Perlin, Steven Park, David W. Denning
  • Publication number: 20170356034
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicants: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Patent number: 9700638
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 11, 2017
    Assignees: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Patent number: 9657355
    Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: May 23, 2017
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Steven Park, David S. Perlin, David Wemyss Denning
  • Patent number: 9657334
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 23, 2017
    Assignees: Rutgers, The State University of New Jersey, Merck & Co., Inc.
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly
  • Publication number: 20160106867
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Application
    Filed: May 8, 2014
    Publication date: April 21, 2016
    Applicants: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Publication number: 20150125856
    Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
    Type: Application
    Filed: June 16, 2014
    Publication date: May 7, 2015
    Inventors: David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer N. Kahn, Stephen A. Parent, Rosemarie Kelly