Patents by Inventor David S. Schwartzman

David S. Schwartzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200170791
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 4, 2020
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Publication number: 20200087371
    Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
    Type: Application
    Filed: July 11, 2019
    Publication date: March 19, 2020
    Inventors: David S. Schwartzman, Sanjeev G. Shroff, Guy Salama, Charles F. McTiernan
  • Patent number: 10583004
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 10, 2020
    Assignee: University of Pittsburgh — Of the Commonwealth System of Higher Education
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Publication number: 20180071088
    Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.
    Type: Application
    Filed: February 26, 2016
    Publication date: March 15, 2018
    Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
  • Publication number: 20170342120
    Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
    Type: Application
    Filed: April 7, 2017
    Publication date: November 30, 2017
    Inventors: David S. Schwartzman, Sanjeev G. Shroff, Guy Salama, Charles F. McTiernan
  • Publication number: 20160206742
    Abstract: Biodegradable triblock copolymer compositions are provided which are useful in preventing and inhibiting bleeding and infection following surgery. The copolymers are reverse thermal gels in that when heated from a lower temperature to a higher temperature, they gel. These gels are useful in drug delivery when complexed with one or more, such as two or more active agents including one or more antibiotics, biofilm inhibitors, procoagulants, and/or analgesics. For example the compositions can be used for injection of active agents, such as antibiotics, procoagulants and analgesics for prevention and/or inhibition of bleeding or infection following surgery. In one example, the disclosed compositions are combined with at least one biofilm inhibitor to prevent and/or inhibit post surgical infection caused by biofilms.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 21, 2016
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Yadong Wang, David S. Schwartzman, Brian A. Klatt
  • Publication number: 20150232526
    Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
    Type: Application
    Filed: October 10, 2013
    Publication date: August 20, 2015
    Applicant: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: David S. SCHWARTZMAN, Sanjeev G. SHROFF, Guy SALAMA, Charles F. MCTIERNAN
  • Publication number: 20110295060
    Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
    Type: Application
    Filed: August 5, 2011
    Publication date: December 1, 2011
    Applicant: University of Pittsburgh of The Commonwealth System of Higher Education
    Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
  • Patent number: 8007504
    Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: August 30, 2011
    Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
    Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
  • Publication number: 20090182326
    Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
    Type: Application
    Filed: March 24, 2009
    Publication date: July 16, 2009
    Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
  • Patent number: 7527634
    Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: May 5, 2009
    Assignee: University of Pittsburgh
    Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
  • Publication number: 20040030335
    Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
    Type: Application
    Filed: May 14, 2003
    Publication date: February 12, 2004
    Applicant: University of Pittsburgh
    Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
  • Patent number: 6597955
    Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: July 22, 2003
    Assignee: EP Technologies, Inc.
    Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
  • Publication number: 20020099415
    Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Application
    Filed: January 4, 2002
    Publication date: July 25, 2002
    Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
  • Patent number: 6370435
    Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: April 9, 2002
    Assignee: EP Technologies, Inc.
    Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
  • Publication number: 20010018608
    Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Application
    Filed: February 14, 2001
    Publication date: August 30, 2001
    Applicant: EP Technologies
    Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
  • Patent number: 6256540
    Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: July 3, 2001
    Assignee: EP Technologies
    Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
  • Patent number: 5718701
    Abstract: An electrode catheter is provided for ablation of arrhythmogenic tissue in a malperforming heart and includes an elongated catheter tube having longitudinally spaced apart proximal and distal ends. At least one electrode for ablation of the arrhythmogenic tissue in a targeted region of the patient is carried on the catheter tube, preferable at or proximate the distal end of the catheter tube. One such electrode may be located at the distal tip of the catheter and configured in the shape of a generally flat disk that substantially conforms to the contour of the targeted region and such that the ratio of the surface area of the tissue-contacting end face to that of a side wall portion of the electrode is greater than 1.0.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: February 17, 1998
    Assignee: Electro-Catheter Corporation
    Inventors: Isaac Shai, Frank E. Marchlinski, David S. Schwartzman
  • Patent number: 5673704
    Abstract: A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: October 7, 1997
    Inventors: Francis E. Marchlinski, David S. Schwartzman, Mark S. Mirotznik, Kenneth R. Foster, Charles D. Gottlieb, Isaac Chang
  • Patent number: 5577509
    Abstract: Systems and methods examine heart tissue morphology using a pair of electrodes, at least one of which is located in contact with heart tissue. The systems and methods transmit electrical current in a path through the contacted heart tissue between the pair of the electrodes to derive a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path. The system and methods also sense with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: November 26, 1996
    Assignee: EP Technologies, Inc.
    Inventors: Dorin N. Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman