Patents by Inventor David S. Schwartzman
David S. Schwartzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108461Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.Type: ApplicationFiled: August 9, 2023Publication date: April 4, 2024Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
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Patent number: 11771555Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.Type: GrantFiled: January 30, 2020Date of Patent: October 3, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
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Publication number: 20220289809Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.Type: ApplicationFiled: November 5, 2021Publication date: September 15, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: David S. Schwartzman, Sanjeev G. Shroff, Guy Salama, Charles F. McTiernan
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Publication number: 20200170791Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.Type: ApplicationFiled: January 30, 2020Publication date: June 4, 2020Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
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Publication number: 20200087371Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.Type: ApplicationFiled: July 11, 2019Publication date: March 19, 2020Inventors: David S. Schwartzman, Sanjeev G. Shroff, Guy Salama, Charles F. McTiernan
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Patent number: 10583004Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.Type: GrantFiled: February 26, 2016Date of Patent: March 10, 2020Assignee: University of Pittsburgh — Of the Commonwealth System of Higher EducationInventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
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Publication number: 20180071088Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.Type: ApplicationFiled: February 26, 2016Publication date: March 15, 2018Inventors: Vinay Badhwar, Young Jae Chun, Antonio D'Amore, David S. Schwartzman, William R. Wagner
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Publication number: 20170342120Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.Type: ApplicationFiled: April 7, 2017Publication date: November 30, 2017Inventors: David S. Schwartzman, Sanjeev G. Shroff, Guy Salama, Charles F. McTiernan
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Publication number: 20160206742Abstract: Biodegradable triblock copolymer compositions are provided which are useful in preventing and inhibiting bleeding and infection following surgery. The copolymers are reverse thermal gels in that when heated from a lower temperature to a higher temperature, they gel. These gels are useful in drug delivery when complexed with one or more, such as two or more active agents including one or more antibiotics, biofilm inhibitors, procoagulants, and/or analgesics. For example the compositions can be used for injection of active agents, such as antibiotics, procoagulants and analgesics for prevention and/or inhibition of bleeding or infection following surgery. In one example, the disclosed compositions are combined with at least one biofilm inhibitor to prevent and/or inhibit post surgical infection caused by biofilms.Type: ApplicationFiled: September 5, 2014Publication date: July 21, 2016Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Yadong Wang, David S. Schwartzman, Brian A. Klatt
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Publication number: 20150232526Abstract: Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.Type: ApplicationFiled: October 10, 2013Publication date: August 20, 2015Applicant: University of Pittsburgh-Of the Commonwealth System of Higher EducationInventors: David S. SCHWARTZMAN, Sanjeev G. SHROFF, Guy SALAMA, Charles F. MCTIERNAN
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Publication number: 20110295060Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.Type: ApplicationFiled: August 5, 2011Publication date: December 1, 2011Applicant: University of Pittsburgh of The Commonwealth System of Higher EducationInventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
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Patent number: 8007504Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.Type: GrantFiled: March 24, 2009Date of Patent: August 30, 2011Assignee: University of Pittsburgh of The Commonwealth System of Higher EducationInventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
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Publication number: 20090182326Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.Type: ApplicationFiled: March 24, 2009Publication date: July 16, 2009Inventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
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Patent number: 7527634Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.Type: GrantFiled: May 14, 2003Date of Patent: May 5, 2009Assignee: University of PittsburghInventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
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Publication number: 20040030335Abstract: A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.Type: ApplicationFiled: May 14, 2003Publication date: February 12, 2004Applicant: University of PittsburghInventors: Marco Zenati, David S. Schwartzman, Mark J. Gartner, Daniel T. McKeel
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Patent number: 6597955Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.Type: GrantFiled: January 4, 2002Date of Patent: July 22, 2003Assignee: EP Technologies, Inc.Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
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Publication number: 20020099415Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.Type: ApplicationFiled: January 4, 2002Publication date: July 25, 2002Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
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Patent number: 6370435Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.Type: GrantFiled: February 14, 2001Date of Patent: April 9, 2002Assignee: EP Technologies, Inc.Inventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
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Publication number: 20010018608Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.Type: ApplicationFiled: February 14, 2001Publication date: August 30, 2001Applicant: EP TechnologiesInventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster
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Patent number: 6256540Abstract: Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.Type: GrantFiled: July 7, 1997Date of Patent: July 3, 2001Assignee: EP TechnologiesInventors: Dorin Panescu, David K. Swanson, Mark S. Mirotznik, David S. Schwartzman, Kenneth R. Foster