Patents by Inventor David S. Shames

David S. Shames has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of gene expression by oligomers targeted to chromosomal DNA
    Patent number: 8324181
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: December 4, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: David R. Corey, David S. Shames, Bethany A. Janowski, John D. Minna
  • Modulation of Gene Expression by Oligomers Targeted to Chromosomal DNA
    Publication number: 20110207217
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Application
    Filed: March 30, 2010
    Publication date: August 25, 2011
    Inventors: David Reid Corey, Bethany Ann Janowski, David S. Shames, John Dorrance Minna
  • Interfering RNAs against the promoter region of P53
    Patent number: 7858592
    Abstract: The present invention relates to the inhibition of p53 transcription by interfering with the activity of a p53 promoter using inhibitory double-stranded RNAs. Use of these inhibitory RNAs in the treatment of cancers also is disclosed.
    Type: Grant
    Filed: February 22, 2008
    Date of Patent: December 28, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: David S. Shames, David R. Corey, Rachel S. Greer, John D. Minna
  • Modulation of gene expression by oligomers targeted to chromosomal DNA
    Patent number: 7709456
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: May 4, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: David R. Corey, David S. Shames, Bethany A. Janowski, John D. Minna
  • INTERFERING RNAS AGAINST THE PROMOTER REGION OF P53
    Publication number: 20090099109
    Abstract: The present invention relates to the inhibition of p53 transcription by interfering with the activity of a p53 promoter using inhibitory double-stranded RNAs. Use of these inhibitory RNAs in the treatment of cancers also is disclosed.
    Type: Application
    Filed: February 22, 2008
    Publication date: April 16, 2009
    Inventors: David S. Shames, David R. Corey, Rachel S. Greer, John D. Minna