Patents by Inventor David S. Warner

David S. Warner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating pruritus
    Patent number: 11065259
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 20, 2021
    Assignees: Duke University, BioMimetix JV, LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Methods and compositions for activation of sirtuins with Annexin A1 peptides
    Patent number: 10172915
    Abstract: The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: January 8, 2019
    Assignee: Duke University
    Inventors: Zhiquan Zhang, Mihai V. Podgoreanu, Qing Ma, David S. Warner, Mark F. Newman
  • METHODS OF TREATING PRURITUS
    Publication number: 20180353516
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 13, 2018
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Methods of treating pruritus
    Patent number: 10080759
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: September 25, 2018
    Assignees: Duke University, BioMimetix J.V., LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • METHODS OF TREATING PRURITUS
    Publication number: 20160324868
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: January 21, 2015
    Publication date: November 10, 2016
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • SUMO as a marker of cancer development and target for cancer therapy
    Patent number: 9169519
    Abstract: Disclosed herein are methods relating to inhibiting or reducing proliferation of a cancer cell, for treating cancer in a subject in need of treatment, predicting the risk of progression of cancer to a more aggressive cancer, and screening for cancer in a subject, that comprise detecting and/or decreasing the levels of SUMO conjugated proteins and detecting and/or interfering with SUMO conjugation.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: October 27, 2015
    Assignee: Duke University
    Inventors: Wulf Paschen, Wei Yang, Huaxin Sheng, David S. Warner
  • Methods and Compositions for Activation of Sirtuins with Annexin A1 Peptides
    Publication number: 20150111830
    Abstract: The present invention provides a method of treating, ameliorating or inhibiting sirtuin-associated disorders and/or conditions in a subject in need thereof, by administering to the subject an effective amount of an ANXA1 peptide.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 23, 2015
    Inventors: Zhiquan Zhang, Mihai V. Podgoreanu, Qing Ma, David S. Warner, Mark F. Newman
  • SUMO AS A MARKER OF CANCER DEVELOPMENT AND TARGET FOR CANCER THERAPY
    Publication number: 20130046010
    Abstract: Disclosed herein are methods relating to inhibiting or reducing proliferation of a cancer cell, for treating cancer in a subject in need of treatment, predicting the risk of progression of cancer to a more aggressive cancer, and screening for cancer in a subject, that comprise detecting and/or decreasing the levels of SUMO conjugated proteins and detecting and/or interfering with SUMO conjugation.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 21, 2013
    Applicant: DUKE UNIVERSITY
    Inventors: Wulf Paschen, Wei Yang, Huaxin Sheng, David S. Warner
  • METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS
    Publication number: 20120065181
    Abstract: Described herein are methods of treating ischemic injury comprising administering to a subject in need thereof a therapeutically effective amount of a substituted porphyrin compound. Also disclosed are methods of providing neuroprotection, methods of treating subarachnoid hemorrhage, methods of treating traumatic brain injury and methods of treating spinal cord injury using substituted porphyrins.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 15, 2012
    Inventors: David S. Warner, Ines Batinic-Haberle, Huaxin Sheng, Ivan Spasojevic
  • TREATING PATIENTS WITH SUBARACHNOID HEMORRHAGE
    Publication number: 20110003012
    Abstract: A method for attenuating vasoconstriction in a patient with subarachnoid hemorrhage by administering to the patient a therapeutically effective amount of a compound which mediates an increase of bioactive nitric oxide in blood or tissue in the subarachnoid space to cause vasodilation in cerebral, carotid and basilar arteries after the administration of the compound, and wherein the administration of the compound does not reduce mean arterial blood pressure by more than 10%.
    Type: Application
    Filed: September 8, 2008
    Publication date: January 6, 2011
    Applicant: Duke University
    Inventors: Jonathan S. Stamler, David S. Warner, James D. Reynolds, Huaxin Sheng