Abstract: The present invention provides new strategies for the treatment of Rett Syndrome and other MECP2-associated disorders, including for the identification and/or characterization of useful therapeutic modalities and/or for the stratification of Rett Syndrome patients to identify those more or less likely to respond to a particular therapy. In some embodiments, the present invention defines certain components of metabolic pathways, and particularly of lipid and/or cholesterol metabolism (e.g., biosynthesis) pathways, most particularly of lipid and/or cholesterol metabolism (e.g., biosynthesis) pathways in the brain, as targets useful in the identification and/or characterization of potential Rett Syndrome treatment agents.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a storage medium, for generating thermal zones. In one aspect, a method includes identifying a perimeter zone for a first portion of a conceptual representation of a building; and dividing the perimeter zone into a plurality of thermal zones, comprising: determining a plurality of first candidate thermal zones based at least in part on a maximum thermal zone angle threshold that each of the first candidate thermal zones satisfy, determining a plurality of second candidate thermal zones based at least in part on a maximum thermal zone length threshold that each of the second candidate thermal zones satisfy, and selecting a plurality of thermal zones from the first candidate thermal zones and the second candidate thermal zones.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a storage medium, for generating thermal zones. In one aspect, a method includes identifying a perimeter zone for a first portion of a conceptual representation of a building; and dividing the perimeter zone into a plurality of thermal zones, comprising: determining a plurality of first candidate thermal zones based at least in part on a maximum thermal zone angle threshold that each of the first candidate thermal zones satisfy, determining a plurality of second candidate thermal zones based at least in part on a maximum thermal zone length threshold that each of the second candidate thermal zones satisfy, and selecting a plurality of thermal zones from the first candidate thermal zones and the second candidate thermal zones.

Abstract: The present invention provides a multifunctional building panel which may comprise a sensor to measure an interior condition and an exterior condition and generate a signal in response, along with systems and methods for designing, optimizing and constructing modular buildings, including buildings constructed at least in part of multifunctional building panels, by utilizing a priority distribution ranking as an optimization constraint.

Abstract: The present invention is directed to a system for collecting, processing and providing access to healthcare treatment information. A first provider computer is provided for collecting and transmitting claim healthcare treatment information relating to a patient. The healthcare treatment information is communicated to a third party payer computer in communication with the first provider computer. A healthcare treatment information processing computer is provided in communication with the provider computer and the third party payer computer comprising computer software for collecting and processing the healthcare treatment information and adapted to display selected healthcare treatment information to a second provider. A method of collecting, processing and making available healthcare treatment information to providers is also provided.

Abstract: The invention concerns a network element and an input-output unit (1) for a synchronous transmission system according to the standard for Synchronous Digital Hierarchy or according to the comparable Synchronous Optical Network (SONET) standard. The input-output unit (1) contains a signal processing device (2) that has a reception data memory (5), a transmission data memory (7), a control unit (6) and a processor (3). The processor (3) is a digital signal processor which essentially carries out the processing of a STM-N signal.

Abstract: Methods of stabilizing lymphocytes and/or stem cells obtained from a mammal by suspending them in an aqueous medium comprising gelatin.