Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: A computer implemented method of distinguishing tumor progression from treatment-related necrosis in digital images of a subject implements a multimodal deep learning architecture from MRI data of a selected anatomical portion of the subject, such as a brain, and corresponding dPET data for the subject with a tracer applied to the anatomical portion of the subject. The computer stores co-registered MRI data frames with dPET data frames as three dimensional (3D) parametric PET maps to identify multi-modal image features of segmented tumor data. A convolutional neural network uses MRI data and selected multi-modal image features as inputs and the computer concatenates respective output latent feature vectors from the respective sections of the at least one CNN. Feeding concatenated feature vectors to fully connected layers of the multimodal architecture distinguishes tumor progression from treatment-related necrosis of the anatomical portion of the subject.

Abstract: A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.

Abstract: Variable temperature analytical assemblies are provided and/or methods for changing temperatures of a mass are provided. Low thermal conductance components and/or assemblies are also provided. Methods for thermally isolating a mass from a support structure are also provided.

Abstract: Variable temperature analytical assemblies are provided and/or methods for changing temperatures of a mass are provided. Low thermal conductance components and/or assemblies are also provided. Methods for thermally isolating a mass from a support structure are also provided.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: An apparatus for entirely removing a medical sharp from a holder to which it is connected, including a body (102), a heating unit (104) disposed in the body, a receiving unit (114) fixedly disposed in the body and configured to receive the holder, and a collet (122) movably disposed within the body and configured to receive the medical sharp. The apparatus also includes a first biasing member (130) disposed within the body, and a user interface (136) coupled to the collet and configured to displace the collet away from the receiving unit, actuate the first biasing member to increase a bias on the collet toward the receiving unit, and actuate the heating unit.

Abstract: User-friendly attachment mechanisms for pen needles provide improved handling and ease of use, including locking installation and removal features and sensory feedback when a needle-bearing hub is seated on a pen.

Abstract: Induction heating from an induction coil (108) is used to separate a metal medical sharp (144) from its holder (142) by applying a high-frequency oscillating magnetic field that excites eddy currents and resistance heating in the sharp. The heated metal sharp melts the adhesive or plastic securing the sharp to its holder. The use of induction heating is advantageous in that it does not require direct contact between the electrical circuit and the sharp or its holder. The heating can also act to sterilize the sharp and thereby render it less hazardous at the same time that it separates the sharp from its holder. The induction coil can have a stepped or conical shape to concentrate the RF energy at the interface between the metal sharp and its holder.

Abstract: Variable temperature analytical assemblies are provided and/or methods for changing temperatures of a mass are provided. Low thermal conductance components and/or assemblies are also provided. Methods for thermally isolating a mass from a support structure are also provided.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: A magazine (18) that stores a plurality of needles (56) configured to engage a medication pen (2) for medication delivery, the magazine (18) comprising a magazine housing (20) enclosing a removable array (26) having a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of huh chambers (22), each connector (28) engages one of the plurality of needle hubs (50), a plurality of peel tabs (30) each sealing one of the plurality of hub chambers (22), and an electronic indicator (62) to identify a status of the plurality of needle hubs (50), wherein the electronic indicator (62) identifies how many of the plurality of needle hubs (50) are unused.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: An e-vaping case includes a housing, a guide structure, a cartridge receiving portion connected to the guide structure, and an electronics system in the housing. The cartridge receiving portion is configured to be moved along the guide structure between a first surface and a second surface of the housing. The electronics system includes a power supply that is configured to initiate a transfer of power to an electrical contact structure if the cartridge receiving portion is moved towards the first surface of the housing to at least a first position of the housing. The electronics system is configured to interrupt the transfer of power to the electrical contact structure if the cartridge receiving portion is moved towards the second surface of the housing. An electronic vaping device may include a cartridge detachably coupled to the cartridge receiving portion.

Abstract: A syringe includes a syringe body having a syringe barrel for receiving and administering a medicament, a hollow needle fluidly communicating with the syringe barrel, and a needle adapter disposed on the syringe body. An outer diameter of the needle adapter is wider than an outer diameter of the syringe barrel, and a distal surface of the needle adapter is substantially flat. The needle adapter facilitates a flush alignment of the distal surface of the needle adapter with at least one of a vial stopper and a vial stopper holder of a medicament vial to ensure that a tip of the needle is properly inserted into the vial to aspirate the medicament within the vial.

Abstract: A pen needle assembly (10) includes a pen needle (12) with a hub body (16) having a needle shield (28) that covers a needle (26) and can be retracted to expose the needle during injection and return to the extended position after use and locked in the extended position. A spring (56) is provided to rotate the needle shield after use to a locked position. A locking member (84) can be provided on the needle shield that cooperates with the hub body (16) to prevent rotation after use. An attachment mechanism (38) for the pen needle provides a sensory indication when a needle-bearing hub body (16) is seated on a pen and limits further rotation of the pen needle relative to the delivery device.