Abstract: A therapeutic molecule (single chain-based antibody or ligand-based) optimized for expression and secretion from engineered T cells, which may be gamma delta (gd) T cells. When expressed from engineered gdT cells, the STAR will be secreted and mediate engagement between gdT cells and antigen/receptor on target cells. Binding mediates the formation of a cytolytic synapse between the gdT cell and the target cell leading to activation the gdT cells to release proteolytic enzymes that kill target cells.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: A compound of Formula (1) and salts thereof: wherein: Q is an optionally substituted aryl ring; Y is CO2H, SO3H or PO3H2; R and X are substituents; m is 0 to 3; n is 0 to 6; and q is 0 to 6. Also compositions comprising these compounds, ink-jet inks, an ink jet process and an ink-jet cartridge.

Abstract: A compound of Formula (1) and salts thereof: wherein: Q is an optionally substituted aryl ring; Y is CO2H, SO3H or PO3H2; R and X are substituents; m is 0 to 3; n is 0 to 6; and q is 0 to 6. Also compositions comprising these compounds, ink-jet inks, an ink jet process and an ink-jet cartridge.

Abstract: An ink comprising a liquid medium and a colorant, wherein the liquid medium comprises water and a water-miscible organic solvent and the colorant is of Formula (1), wherein the colorant is dissolved in the liquid medium: Formula (1) wherein: each independently is a water-solubilising group selected from sulfo, carboxy, phosphato and poly(ethylene oxide); each Z independently is optionally substituted alkyl, optionally substituted aryl or optionally substituted aralkyl; each Q independently is a direct bond or —NR— wherein R is H, optionally substituted aryl or optionally substituted alkyl; rings A,B,C and D are each independently unsubstituted or carry a substituent selected from optionally substituted alkyl, optionally substituted aryl and optionally substituted aralkyl; each n independently is from 1 to 3; and each m independently is 0, 1 or 2; provided that when either or both of the groups represented by Q is a direct bond then at least one n has a value of at least 2.

Abstract: An ink comprising a liquid medium and a colorant, wherein the liquid medium comprises water and a water-miscible organic solvent and the colorant is of Formula (1), wherein the colorant is dissolved in the liquid medium: Formula (1) wherein: each independently is a water-solubilising group selected from sulfo, carboxy, phosphato and poly(ethylene oxide); each Z independently is optionally substituted alkyl, optionally substituted aryl or optionally substituted aralkyl; each Q independently is a direct bond or —NR— wherein R is H, optionally substituted aryl or optionally substituted alkyl; rings A,B,C and D are each independently unsubstituted or carry a substituent selected from optionally substituted alkyl, optionally substituted aryl and optionally substituted aralkyl; each n independently is from 1 to 3; and each m independently is 0, 1 or 2; provided that when either or both of the groups represented by Q is a direct bond then at least one n has a value of at least 2.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: An exemplary oil burning lamp comprises a reservoir configured for storing a supply of oil, a base, a burner tube and a wick. The base is being sized and shaped to receive the reservoir. The burner tube is movably mounted to the reservoir between a retracted position and an extended position. The burner tube has a first end, an opposing second end and at least one opening. In the retracted position, the both ends are located within the reservoir. In the extended position, the first end is located within the reservoir, the second end is located outside the reservoir, and the opening is located such that fragranced components of oil stored in the reservoir can be entrained by air and emanated from the base. The wick is mounted to the burner tube, extends into the reservoir, and extends outwardly from the second end of the burner tube.

Abstract: The invention provides methods and materials involved in delivering nucleic acid to cells and regulating expression of nucleic acid in cells.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: The present invention relates to multi-ribozymes and their use to target RNA in a tissue-specific, target RNA-specific, or pathogen-specific manner for the treatment of cancers, proliferative disease, and bacterial, parasitic and viral infections. More specifically, the present invention relates to the use of virions and viral vectors to package and deliver DNA encoding the multi-ribozymes to a host. The present invention relates to the use of liposomes and lipid-DNA complexes to deliver DNA encoding ribozymes to a host. Most specifically, the invention relates to the use of target specific virions to package and deliver DNA comprising a target specific promoter and encoding a ribozyme(s) directed to the target organism nucleic acids. The present invention further relates to a novel vectors encoding a multi-ribozyme structure with enhanced 5′ and/or 3′ autocatalytically cleaving ribozymes.

Abstract: A process for the preparation of butane triols is provided. In the process, a malic acid diester is reduced with sodium borohydride in the presence of an ether and an alcohol. Preferably, the malic acid diester is an ethyl or methyl ester, the ether is tetrahydrofuran or bis(2-methoxyethyl) ether (diglyme), and the alcohol comprises ethanol. Advantageously, the reaction is carried out at ambient temperature.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: Benzamides of the formula (I): ##STR1## in which Ar is optionally substituted aryl; X is O, S or NH and R is optionally substituted alkyl or alkenyl when X is O or S, or is optionally substituted alkanoyl when X is NH, are prepared by(a) reacting a compound of the formula (II):ArCONHCH.sub.2 CN (II)with a brominating agent in a solvent which is substantially chemically inert to the reactants and in which compound (II) is soluble, to form a compound of the formula (III): ##STR2## and (b) reacting the compound (III) with a compound RXH.Preferably, bromination is carried out rapidly in dried ethyl acetate.The process avoids hydration of the CN group of the compound (III) to a carbamoyl group obviating a subsequent dehydration step later.The intermediate compound (III) is novel.The substituted benzamides are useful as herbicides and fungicides.

Abstract: Substituted naphthalenyloxy- or naphthalenylthiooxyamides of trans-1,2-diaminocyclohexanes possess selective kappa opioid receptor site binding activity and are thus useful as analgesic or diuretic agents. Methods of preparing the compounds, pharmaceutical compositions, and a method for their use as analgesic agents are also disclosed.

Abstract: Benzamides of the formula (I): ##STR1## in which Ar is optionally substituted aryl; X is O, S or NH and R is optionally substituted alkyl or alkenyl when X is O or S, or is optionally substituted alkenoyl when X is NH, are prepared by(a) reacting a compound of the formula (II):ArCONHCH.sub.2 CN (II)with a brominating agent in a solvent which is substantially chemically inert to the reactants and in which compound (II) is soluble, to form a compound of the formula (III): ##STR2## and (b) reacting the compound (III) with a compound RXH.Preferably, bromination is carried out rapidly in dried ethyl acetate.The process avoids hydration of the CN group of the compound (III) to a carbamoyl group obviating a subsequent dehydration step later.The intermediate compound (III) is novel.The substituted benzamides are useful as herbicides and fungicides.

Abstract: The invention provides a computer store having successively addressed storage locations for individual words grouped together to form so-called clotheslines. Data can be written into and read out from either end of a clothesline. A clothesline thus combines the properties of a stack and a silo and can be considered as either a double-ended stack or as a reversible silo.

Abstract: Process for the preparation of esters of m-phenoxybenzyl alcohol and its .alpha.-cyano and .alpha.-ethinyl derivatives with carboxylic acids containing at least 6 carbon atoms by heating together a methyl or ethyl ester of the carboxylic acid, an ester of m-phenoxyphenyl alcohol or its .alpha.-cyano or .alpha.-ethinyl derivative with an acid of the formula R.CO.sub.2 H wherein R is an alkyl group containing not more than 3 carbon atoms, and tetramethyl or tetraethyl titanate at a temperature such that the methyl or ethyl ester of the acid of formula R.CO.sub.2 H is removed by distillation as it is formed.