Patents by Inventor David Schuz

David Schuz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140328770
    Abstract: A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
    Type: Application
    Filed: July 9, 2014
    Publication date: November 6, 2014
    Inventors: Dov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan
  • Patent number: 8871184
    Abstract: A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents; and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30%; wherein the tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: October 28, 2014
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Rita Keynan, Nukri Papiashvili
  • Patent number: 8865139
    Abstract: A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 21, 2014
    Assignee: Foamix Pharmaceuticals Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan
  • Publication number: 20140271494
    Abstract: Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
    Type: Application
    Filed: January 22, 2014
    Publication date: September 18, 2014
    Applicant: FOAMIX LTD.
    Inventors: Dov Tamarkin, Rita Keynan, David Schuz, Tal Berman
  • Publication number: 20140248219
    Abstract: The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
    Type: Application
    Filed: February 25, 2014
    Publication date: September 4, 2014
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, Doron Friedman, Enbal Ziv, Meir Eini, Tal Berman, Jorge Danziger, Rita Keynan, David Schuz
  • Patent number: 8795693
    Abstract: The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: August 5, 2014
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Tal Berman, David Schuz
  • Patent number: 8795635
    Abstract: The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: August 5, 2014
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Doron Friedman, Enbal Ziv, Meir Eini, Tal Berman, Jorge Danziger, Rita Keynan, David Schuz
  • Publication number: 20140186269
    Abstract: The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active agents for the treatment of human skin, especially in the treatment of acne, acne related symptoms, a tetracycline antibiotic responsive acne related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. acne bacteria associated disorders, and other superficial infections, including skin infections.
    Type: Application
    Filed: January 3, 2014
    Publication date: July 3, 2014
    Inventors: Dov Tamarkin, Elana Gazal, Rita Keynan, Meir Eini, David Schuz
  • Publication number: 20140121188
    Abstract: Methods of treatment and dosage regimes using hydrophobic gel or foam composition comprising a tetracycline antibiotic in treating or alleviating a disorder including, acne, acne related symptoms, a tetracycline antibiotic responsive acne related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. acne bacteria associated disorders and other superficial infections, including skin infections wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin.
    Type: Application
    Filed: January 3, 2014
    Publication date: May 1, 2014
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Rita Keynan, Meir Eini, David Schuz
  • Patent number: 8709385
    Abstract: Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1% to about 15% by weight; wherein when the Poloxamer is between about 0.1% to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: April 29, 2014
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Alex Besonov, Tal Berman, David Schuz, Elana Gazal
  • Publication number: 20140066524
    Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 6, 2014
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
  • Publication number: 20140050673
    Abstract: A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
    Type: Application
    Filed: August 15, 2013
    Publication date: February 20, 2014
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, David Schuz, Yohan Hazot, Elana Gazal
  • Patent number: 8636982
    Abstract: Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: January 28, 2014
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Rita Keynan, David Schuz, Tal Berman
  • Patent number: 8618081
    Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: December 31, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
  • Patent number: 8617100
    Abstract: A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: December 31, 2013
    Assignee: Foamix Ltd.
    Inventors: Meir Eini, David Schuz, Helen Shifrin, Yohan Hazot, Dov Tamarkin
  • Patent number: 8518376
    Abstract: A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: August 27, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, David Schuz, Yohan Hazot, Elana Gazal
  • Patent number: 8486374
    Abstract: A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: July 16, 2013
    Assignee: Foamix Ltd.
    Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Alex Besonov, David Schuz, Tal Berman, Jorge Danziger, Rita Keynan, Ella Zlatkis
  • Publication number: 20130161351
    Abstract: A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.
    Type: Application
    Filed: July 12, 2011
    Publication date: June 27, 2013
    Applicant: FOAMIX LTD.
    Inventors: Meir Eini, Tami Winitz, David Schuz
  • Publication number: 20130064777
    Abstract: A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.
    Type: Application
    Filed: October 1, 2010
    Publication date: March 14, 2013
    Applicant: FOAMIX LTD.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Rita Keynan, Nukri Papiashvili
  • Publication number: 20130053353
    Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
    Type: Application
    Filed: May 4, 2011
    Publication date: February 28, 2013
    Applicant: FOAMIX LTD.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz