Abstract: Systems and techniques for determining a sideslip vector for a vehicle that may have a direction that is different from that of a heading vector for the vehicle. The sideslip vector in a current vehicle state and sideslip vectors in predicted vehicles states may be used to determine paths for a vehicle through an environment and trajectories for controlling the vehicle through the environment. The sideslip vector may be based on a vehicle position that is the center point of the wheelbase of the vehicle and may include lateral velocity, facilitating the control of four-wheel steered vehicle while maintaining the ability to control two-wheel steered vehicles.

Abstract: An armchair comprising a seat chassis supported on a support chassis by a pair of support columns, a chair back structure pivotally attached to a rear end of the seat chassis and to the support chassis, and a leg support structure pivotally attached to a front end of the seat chassis and connected to a beam, wherein the beam is attached the chair back structure. A first actuating device is mounted to the chair back, where a protracting end of the first actuating device is connected to the seat chassis. The armchair further comprises a second actuating device mounted to the support chassis, a footrest connected to a protracting end of the second actuating device, a third actuating device attached to the seat chassis, and a seating structure connected to a protracting end of the third actuating device and mounted above the seat chassis, wherein the seating structure includes an operative position projecting upwards and forwards by the third actuating device at a tilting angle from the seat chassis.

Abstract: An incorrect copy of a record of data can be prevented from being transmitted to a distributed ledger system. A first file can be received and can include information, in audio or video form, with a description of a subject matter of the record of data and with an authorization to transmit the copy to the distributed ledger system. The first file can be sent to a device. A second file can be received from the device and can include information that confirms that the description of the subject matter, included in the first file, is correct, and that confirms that an entity, which controlled production of the first file, has permission to authorize causing the copy to be transmitted to the distributed ledger system. The correct copy can be caused, based on a receipt of the first and the second files, to be transmitted to the distributed ledger system.

Abstract: A method of screening a test compound, e.g., a fibrosis or IPF inhibitor, for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease includes culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium contacting the cultured cells with the test compound; and monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary; wherein stationary cultured cells indicate that the test compound induces the UJT. Also included are methods of identifying lung fibrosis biomarkers.

Abstract: The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity. Also provided are compositions comprising panels of immunoreagents specific for multiple different target antigens and compositions comprising pairs of primary immunoreagents and their complementary detectable secondary antibodies. The paired primary immunoreagents and secondary antibodies are useful in a variety of immunologic assays, particularly in highly multiplexed assays, where the structure of the bridging antigen is varied in tandem with variation in the detectable secondary antibody, such that a multiplicity of immunoreagents are provided that are capable of simultaneously detecting a multiplicity of target antigens in a single assay.

Abstract: Vacuum toilet flush valves. The disclosure uses a precise positioning of a magnet with respect to a flush valve plate in order to identify absolute alignment accurately.

Abstract: Generating one or more high-resolution atmospheric gas concentration maps using geography-informed machine learning includes obtaining a remote sensing dataset constrained by at least one temporal window and at least one spatial window defining a first geographic area. The remote sensing dataset includes at least a first set of atmospheric gas concentration data for a plurality of atmospheric gases. A training dataset is generated based on the remote sensing dataset. A machine learning model is trained with the training dataset to predict a plurality of atmospheric gas concentration values for at least one atmospheric gas of the plurality of atmospheric gases in a given geographic area and with a spatial resolution that is greater than a spatial resolution of atmospheric gas concentration data provided as an input to the machine learning module.

Abstract: A geography-informed machine learning (GIML) model is trained on a first remote sensing dataset corresponding to a first geographic area and including a first set of atmospheric gas concentration data for at least one atmospheric gas, a first set of multispectral data, and a first set of spatially autocorrelated land use classifications. The GIML model receives input including a second remote sensing dataset corresponding to a second geographic area. The second remote sensing dataset includes a second set of atmospheric gas concentration data for the atmospheric gas, a second set of multispectral data, and a second set of spatially autocorrelated land use classifications. The GIML model generates, for the second geographic area, a plurality of predicted atmospheric gas concentration values for the atmospheric gas having a spatial resolution that is greater than a spatial resolution of the first and second sets of atmospheric gas concentration data.

Abstract: This document describes techniques, apparatuses, and systems for a grid-based road model with multiple layers. An example road-perception system generates a roadway grid representation that includes multiple cells. The road-perception system uses data from multiple information sources to generate a road model that includes multiple layers. Each layer represents a roadway attribute of each cell in the grid and includes one or more layer hypotheses. In this way, the described techniques and systems can provide an accurate and reliable road model and quantify uncertainty therein.

Abstract: A differentiable physics model of a building is used that defines thermodynamic relationships between zones of the building and a heating, ventilation, and air-conditioning (HVAC) system. A physics-constrained, data driven model learns behaviors of controlled components of the HVAC system. For each of a series of times during online operation of the HVAC system, past state values are recorded representing a performance of the HVAC system in the building and past inputs to the HVAC system to maintain the states. The past state values and the past inputs are input into the differentiable physics model and the data driven model to: jointly update first parameters of the differentiable physics model and second parameters of the data driven model, e.g., using moving horizon estimation; and determine a current input to the controlled components, e.g., using model predictive control.

Abstract: The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity. Also provided are compositions comprising panels of immunoreagents specific for multiple different target antigens and compositions comprising pairs of primary immunoreagents and their complementary detectable secondary antibodies. The paired primary immunoreagents and secondary antibodies are useful in a variety of immunologic assays, particularly in highly multiplexed assays, where the structure of the bridging antigen is varied in tandem with variation in the detectable secondary antibody, such that a multiplicity of immunoreagents are provided that are capable of simultaneously detecting a multiplicity of target antigens in a single assay.

Abstract: The present disclosure provides a method of treating a fibrotic lung disease in a subject comprising administering to the subject an effective amount of a therapeutic agent, wherein the subject is asymptomatic and wherein the subject is at risk of developing the fibrotic lung disease.

Abstract: Methods, computer readable media, and devices for escrow of master keys and recovery of previously escrowed master keys may be disclosed. A method for escrow of master keys may include registering a root certificate authority (CA) within each of two first-party hardware security modules (HSMs), initializing each of three third-party HSMs as master escrow recovery devices, performing a bootstrap operation on an authoritative blockchain to generate three master keys, generating a first set of master key shard ciphertexts using a first one of the three master escrow recovery devices, a second set using a second one of the three master escrow recovery devices, and a third set using a third one of the three master escrow recovery devices, and storing the first, the second, and the third set of master key shard ciphertexts as opaque objects in each of the two first-party HSMs.

Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Abstract: This document describes techniques and systems to make determinations of lane-type and roadway hypotheses in a road model. The road-perception system can fuse various forms of evidence to determine lane-type hypotheses and respective belief masses associated with the lane-type hypotheses. The road-perception system the computes, using the belief masses, a belief parameter and a plausibility parameter associated with the lane-type hypotheses. One or more roadway hypotheses are then determined using the lane-type hypotheses. The road-perception system then uses the respective belief parameter and plausibility parameter associated with the lane-type hypotheses to compute a belief parameter and a plausibility parameter associated with the roadway hypotheses. In this way, the described techniques and systems can provide an accurate and reliable road model with quantified uncertainty.

Abstract: Various designs of die shoe assemblies are provided, each assembly configured to adjust vertical positioning of a die platform within the assembly, in order to correspondingly adjust vertical positioning of a die used with the assembly. The assemblies address limitations often associated with conventional die shoes designed to be used with shims. The assemblies use various methods and corresponding mechanisms to make the adjustment a time efficient process, while in so doing also enabling the desired extent of adjustment to be effectively and accurately provided.

Abstract: Methods, computer readable media, and devices for escrow of master keys and recovery of previously escrowed master keys may be disclosed. A method for escrow of master keys may include registering a root certificate authority (CA) within each of two first-party hardware security modules (HSMs), initializing each of three third-party HSMs as master escrow recovery devices, performing a bootstrap operation on an authoritative blockchain to generate three master keys, generating a first set of master key shard ciphertexts using a first one of the three master escrow recovery devices, a second set using a second one of the three master escrow recovery devices, and a third set using a third one of the three master escrow recovery devices, and storing the first, the second, and the third set of master key shard ciphertexts as opaque objects in each of the two first-party HSMs.

Abstract: This document describes techniques, apparatuses, and systems for a grid-based road model with multiple layers. An example road-perception system generates a roadway grid representation that includes multiple cells. The road-perception system uses data from multiple information sources to generate a road model that includes multiple layers. Each layer represents a roadway attribute of each cell in the grid and includes one or more layer hypotheses. In this way, the described techniques and systems can provide an accurate and reliable road model and quantify uncertainty therein.

Abstract: An engine braking system includes engine braking actuators for adjusting exhaust valve timings to engine braking timings in a cylinder-number braking mode. The system further includes an engine braking controller coupled to a control switch that produces a request indicating a requested cylinder-number braking mode. The engine braking controller is structured to transition exhaust valves to the engine braking timings, determine a control term to adjust intake air pressure for varying a braking power of the engine, and to adjust geometry of an exhaust turbine based on the control term. An adjusted speed of a compressor rotated by the exhaust turbine provides a change to intake air pressure that adjusts the braking power of the engine. Different levels of braking power are provided within different cylinder-number braking modes.