Patents by Inventor David Scott Johnson

David Scott Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10405912
    Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: September 10, 2019
    Assignee: Ablative Solutions, Inc.
    Inventors: David R. Fischell, Tim A. Fischell, Robert Ryan Ragland, Darrin James Kent, Andy Edward Denison, Eric Thomas Johnson, Jeff Alan Burke, Christopher Scott Hayden
  • Publication number: 20190269435
    Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
    Type: Application
    Filed: March 8, 2019
    Publication date: September 5, 2019
    Inventors: David R. Fischell, Tim A. Fischell, Robert Ryan Ragland, Darrin James Kent, Andy Edward Denison, Eric Thomas Johnson, Jeff Alan Burke, Christopher Scott Hayden, Robert E. Fischell
  • Publication number: 20190256841
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20190225752
    Abstract: The present disclosure provides a curable system containing a benzoxazine and a benzothiazole sulfenamide. The curable system may be catalyzed at temperatures generally used to cure multifunctional epoxy resins yet exhibits improved pot-life and processing times and provides a cured article that exhibits acceptable thermo mechanical properties.
    Type: Application
    Filed: May 9, 2017
    Publication date: July 25, 2019
    Inventors: Derek Scott Kincaid, Dong Le, David L. Johnson
  • Patent number: 10350392
    Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also control the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 16, 2019
    Assignee: Ablative Solutions, Inc.
    Inventors: David R. Fischell, Tim A. Fischell, Robert Ryan Ragland, Darrin James Kent, Andy Edward Denison, Eric Thomas Johnson, Jeff Alan Burke, Christopher Scott Hayden, Robert E. Fischell
  • Patent number: 10329557
    Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 25, 2019
    Assignee: GigaGen, Inc.
    Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
  • Patent number: 10214740
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: February 26, 2019
    Assignee: GigaGen, Inc.
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20190002974
    Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 3, 2019
    Inventors: David Scott Johnson, Everett Hurteau Meyer
  • Patent number: 10106789
    Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: October 23, 2018
    Assignee: GigaGen, Inc.
    Inventors: David Scott Johnson, Everett Hurteau Meyer
  • Publication number: 20180258422
    Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
    Type: Application
    Filed: March 13, 2018
    Publication date: September 13, 2018
    Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
  • Patent number: 9926554
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: March 27, 2018
    Assignee: GigaMune, Inc.
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Patent number: 9926555
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: March 27, 2018
    Assignee: GigaMune, Inc.
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20170247684
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Application
    Filed: May 18, 2017
    Publication date: August 31, 2017
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20170247683
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Application
    Filed: May 18, 2017
    Publication date: August 31, 2017
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Patent number: 9738699
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 22, 2017
    Assignee: GigaGen, Inc.
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20170204460
    Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
    Type: Application
    Filed: March 17, 2017
    Publication date: July 20, 2017
    Inventors: David Scott Johnson, Everett Hurteau Meyer
  • Patent number: 9695474
    Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: July 4, 2017
    Assignee: GigaGen, Inc.
    Inventors: David Scott Johnson, Everett Hurteau Meyer
  • Publication number: 20170166889
    Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 15, 2017
    Inventors: David Scott Johnson, Everett Hurteau Meyer
  • Publication number: 20160362683
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Application
    Filed: May 16, 2016
    Publication date: December 15, 2016
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
  • Publication number: 20160362681
    Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
    Type: Application
    Filed: May 16, 2016
    Publication date: December 15, 2016
    Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi