Patents by Inventor David Scott Kittle
David Scott Kittle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230228683Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: ApplicationFiled: July 21, 2022Publication date: July 20, 2023Inventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 11428636Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: GrantFiled: March 11, 2021Date of Patent: August 30, 2022Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20210255107Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: ApplicationFiled: March 11, 2021Publication date: August 19, 2021Inventors: Pramod BUTTE, Paul LAPCHAK, David Scott KITTLE
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Patent number: 10983060Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: April 12, 2019Date of Patent: April 20, 2021Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20200096447Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: ApplicationFiled: April 12, 2019Publication date: March 26, 2020Inventors: Pramod BUTTE, Paul LAPCHAK, David Scott KITTLE
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Patent number: 10288567Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: June 29, 2016Date of Patent: May 14, 2019Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20170290515Abstract: Provided herein are methods for classifying or characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy and/or electrical stimulation. A biological sample may produce a responsive fluorescence signal when irradiated by a light excitation signal or pulse at a predetermined wavelength. The responsive fluorescence signal may be recorded. The intensity of the excitation wavelength may be recorded and used to normalize the recorded responsive fluorescence signal. The biological sample may produce a responsive electrical signal in response to electrical stimulation. Raw fluorescence decay data may be generated from the responsive fluorescence signal and pre-processed. The pre-processed raw fluorescence decay data may be de-convolved to remove an instrument response function therefrom and generate true fluorescence decay data.Type: ApplicationFiled: April 7, 2017Publication date: October 12, 2017Inventors: Pramod BUTTE, Chirag PATIL, Keith L. BLACK, Fartash VASEFI, David Scott KITTLE, Bartosz BORTNIK, Zhaojun NIE
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Publication number: 20160377547Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: ApplicationFiled: June 29, 2016Publication date: December 29, 2016Applicant: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 9404870Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: March 17, 2014Date of Patent: August 2, 2016Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20160048981Abstract: The disclosure provides systems and methods for characterizing spatial distortions in location data determined by an imaging system, e.g., as employed in imaged guided therapy. A custom-formed three dimensional phantom for an imaging system includes a plurality of control points fixed in space with well-known positions. The phantom is fixed to a stereotactic frame defining a calibrated reference and imaged. The image data is analyzed to determine spatial locations of the control points. A comparison is made between the known and determined spatial locations for at least a subset of the control points to compensate for spatial distortion in the raw image data. The control points can have fixed locations known to an accuracy of about 100 ?m or better. The initial estimate for the detected location of a control point can be accurate to about ±0.5 pixel or better.Type: ApplicationFiled: May 28, 2015Publication date: February 18, 2016Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Publication number: 20160003742Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: ApplicationFiled: March 17, 2014Publication date: January 7, 2016Applicant: CEDARS-SINAI MEDICAL CENTERInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 9196082Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100 ?m or better.Type: GrantFiled: May 1, 2014Date of Patent: November 24, 2015Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Publication number: 20150030223Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100 ?m or better.Type: ApplicationFiled: May 1, 2014Publication date: January 29, 2015Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Patent number: 8737707Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100.mu. or better.Type: GrantFiled: April 13, 2012Date of Patent: May 27, 2014Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Publication number: 20120200563Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100.mu. or better.Type: ApplicationFiled: April 13, 2012Publication date: August 9, 2012Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Patent number: 8189889Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100? or better.Type: GrantFiled: February 20, 2009Date of Patent: May 29, 2012Assignee: Loma Linda University Medical CenterInventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser
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Publication number: 20100021029Abstract: Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100? or better.Type: ApplicationFiled: February 20, 2009Publication date: January 28, 2010Inventors: Robert D. Pearlstein, David Scott Kittle, Barbara Ann Holshouser