Patents by Inventor David Senica

David Senica has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Concentrating aqueous fractions of lisinopril by reverse osmosis
    Publication number: 20050010056
    Abstract: The present invention describes a process for purification and isolation of lisinopril where the reverse osmosis is used for concentrating the aqueous fractions.
    Type: Application
    Filed: November 8, 2002
    Publication date: January 13, 2005
    Inventors: Janez Rzen, David Senica, Pavel Drnovsek
  • Process for the obtaining of HMG-COA reductase inhibitors of high purity
    Patent number: 6825015
    Abstract: A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which process comprises: clarifying a mycelium broth and concentrating the clarified broth to a lower volume, acidifying of the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, crystallization of the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, and crystallization of the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water. The crystallization steps may also be reverse. The concept of a combination of the specified crystallization steps can also be used for the purification of a crude HMG-CoA reductase inhibitor.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: November 30, 2004
    Assignee: LEK Pharmaceuticals d.d.
    Inventors: Zlatko Pflaum, Dusan Milivojevic, David Senica