Patents by Inventor David Seymour Latchman

David Seymour Latchman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell lines for the propagation of mutated herpes viruses
    Patent number: 7262033
    Abstract: A process for propagating a mutant herpes virus having a mutation in its endogenous HSV VP16 gene or a homologue thereof, which process comprises infecting a cell line with the mutant herpes virus and culturing the cell line, wherein the cell line comprises a nucleic acid sequence encoding a functional herpes simplex virus (HSV) VP16 polypeptide, or a homologue thereof, operably linked to a control sequence permitting expression of the polypeptide in said cell line; the nucleic acid sequence being (i) capable of complementing the endogenous gene and (ii) unable to undergo homologous recombination with the endogenous gene. In addition, the present invention provides cell lines which can be used for the growth of mutant herpes viruses which have defects in certain immediate early genes together with mutations in VP16 or homologue thereof.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: August 28, 2007
    Assignee: Biovex Limited
    Inventors: Robert Stuart Coffin, David Seymour Latchman
  • Mutant herpes simplex viruses and uses thereof
    Publication number: 20040063094
    Abstract: A herpes simplex virus (HSV) comprising (i) an HSV LAT sequence inserted into an essential gene of the HSV; and (ii) a deletion in the endogenous LAT region of the HSV strain. The HSV of the invention can be used in the treatment of disorders of, or injuries to, the nervous system of a mammal.
    Type: Application
    Filed: September 24, 2003
    Publication date: April 1, 2004
    Applicant: BIOVEX LIMITED
    Inventors: Robert Stuart Coffin, David Seymour Latchman
  • HSV strain lacking functional ICP27 and ICP34.5 genes
    Patent number: 6248320
    Abstract: The present invention provides a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene. It also provides the use of a herpes simplex virus strain which lacks a functional ICP34.5 gene and a functional ICP27 gene in the treatment of disorders of, or injuries to, the nervous system of a mammal.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: June 19, 2001
    Assignees: University College London, The University Court of the University of Glasgow
    Inventors: Robert Stuart Coffin, David Seymour Latchman, Alasdair Roderick Maclean, Suzanne Moira Brown