Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A storage rack is provided for storing glass sheets. The rack includes substantially horizontal and vertical portions. The substantially horizontal and/or vertical portion(s) of the rack include(s) one or more flexible supports, each including at least one channel. Arms are attached to the left and right sides of the rack. The rear legs have tabs attached thereto, with lower lips extending away from the rack. The rack is stackable with another rack, e.g., with the upper rack's rear sitting on the lower rack's arms, and with the upper rack's front supported by a support member extending upwardly from tubing provided in the lower rack that is accommodated in holes/recesses of the upper rack. The arms are sized, shaped, and arranged to reduce the likelihood of tipping of the upper rack, and the tabs help mitigate the effect of side-to-side movement of the upper rack relative to the lower rack.

Abstract: Unique systems, methods, techniques and apparatuses of a power line measurement device are disclosed. One exemplary embodiment is a measurement device comprising a measurement device structured to at least partially surround a segment of a power distribution line, the measurement device including a winding portion spaced apart from the segment of the power distribution line structured to receive magnetic flux from the power distribution line and to output data corresponding to a current flowing through the power distribution line; and a magnetic shield spaced apart from the measurement device and positioned radially outward from the winding portion relative to the segment of the power distribution line, the magnetic shield comprising a first section and a second section coupled to the first section at an obtuse angle, the magnetic shield being structured to reduce an amount of external flux from being received with the measurement device.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a command is transmitted causing a client device to present a workflow action to perform. A user command to perform the workflow action is identified using the client device. Authentication data including user credentials and a navigation action for a visual user interface is identified. The user credentials are transmitted to the network service and an emulation of the navigation action is performed. A command that performs the workflow action is transmitted to the network service.

Abstract: A system and method are that includes a frame and a weapon mount on the frame that receives a weapon mock-up. The method includes setting up a trainer simulator including opening a transportable shipping container, wherein the transportable shipping container includes a coupled integrated common base frame and a universal mount tower. The method includes assembling a seat and pivoting the universal mount tower from a horizontal position to a vertical position wherein the universal mount tower auto-locks into position. The method includes delivering ground vehicle based weapon system training to a user using a continuum of human interface fidelities that includes a first, second and third fidelity, wherein the user is first delivered training at a first fidelity, and then at a second fidelity and then at a third fidelity. A system for a mission reconfigurable trainer simulation is also presented.

Abstract: A first device is configured to establish a connection over a short-range communication link with a second device. The first device may transition to a sleep state, terminate (i) a paging operation and a page scanning operation associated with a paging protocol and (ii) an advertisement scanning operation associated with an advertisement protocol and perform an advertisement broadcast operation associated with the advertisement protocol, the advertisement broadcast operation generating an advertisement to be broadcast at a first interval, wherein the first interval is greater than a second interval for performing advertisement broadcast operations in an active state.

Abstract: This disclosure relates to a fuel or charging port door assembly of a motor vehicle. In particular, this disclosure relates to a fuel or charging port door assembly configured to permit a door to open when an override force is applied using an assist tool, for example. An example vehicle includes a door configured to move relative to a body of the vehicle between open and closed positions. The door is a fuel door or a charging port door. The vehicle also includes a lock assembly including a base and a tip. The base is configured to hold the tip during normal operating conditions, and the base and tip are configured to separate upon application of an override force to the door.

Abstract: A lift gas injection system that is used for introducing lift gas into a stream of production fluid includes a lift gas injection valve. A pressure protection system guards the injection valve against external overpressure by blocking communication to inside the injection valve housing when ambient pressure exceeds a set pressure. Communication is blocked by moving a valve member so that it obstructs flow through an opening in the housing. The system includes pressure actuated valve which has a platen mounted to an end of a bellows, and a valve member coupled to the platen. Surface area is reduced on the bellows side of the platen that creates a force imbalance on the platen from applied ambient pressure. At the set pressure the force imbalance moves the platen, and which pushes the valve member against the opening. A compressible pressure compensator inside the injection valve protects against internal overpressure.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a workflow service identifies a workflow action and a user account that is responsible for the workflow action. A command to present the workflow action for user authorization is transmitted to a client device associated with the user account. The workflow service transmits a command to perform the workflow action based on an identification of the user authorization.

Abstract: There is disclosed a system, including apparatus, methods and computer programs, for running native software applications (apps) and HTML5 web-based apps on a computing device, particularly a mobile computing device, in a multitasking mode of operation. In one embodiment, touch screen displays having one or more browsers are adapted to run one or more HTML5 apps, and receive input from hand gestures. One or more software modules execute on the operating system and are responsive to a dragging gesture applied to an HTML5 app displayed in a full screen mode, to subdivide the screen display and display the HTML5 app in one of the subdivided areas and display icons used to launch a second HTML5 app in a different one of the subdivided areas. The second HTML5 app is run concurrently with the first HTML5 app in order to provide multi-tasking between the first and second apps.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, an event is detected. The event is associated with an enterprise. A workflow action to perform is identified based on event. A user account is identified using at least one of the workflow action and the event. A command to present the workflow action is transmitted to a client device. A user indication to perform the workflow action is identified. Authentication data for the network service is identified based on a single sign-on (SSO) token associated with the user account. The workflow action is automatically performed using the network service. An authentication with the network service is completed based on the authentication data.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a data request is received. The request is associated with a network service. A single sign-on (SSO) token is received. The SSO token represents a user account authenticated with an identity manager. Authentication data for the network service is identified based on the SSO token. The authentication data can specify an authentication site of the network service. A navigation action is automatically performed on the authentication site. The requested data is received. A command to present on a client device the data is transmitted to the client device.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a hosting location is identified for a connector that handles communications with a network service. Authentication information that is selected based on the hosting location of the connector is appended to a service request. The authentication information includes a service credential that the connector uses to authenticate with the network service, if the connector is hosted locally to the workflow service. The authentication information includes instructions for the connector to retrieve the service credential from an enterprise-hosted data store, if the connector is hosted external to the workflow service. The service request is then transmitted with the selected authentication information.

Abstract: Disclosed are various approaches for retrieving contacts from a plurality of federated services. In one example, an authentication notification is received from an identity manager. The authentication notification can include an identifier for a user account and a single sign-on token for the user account. A federated service to authenticate on behalf of the user account is identified. The single sign-on token is transmitted to the federated service for authentication. An authentication token and a refresh token is received from the federated service. The authentication token is determined to expire within a threshold time period. The refresh token is has not expired. The refresh token is transmitted to the federated service for a replacement authentication token.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a service request is identified. The service request is associated with a network service. A single sign-on (SSO) token is received. The SSO token represents a user account authenticated with an identity manager. Authentication data for the network service is identified based on the SSO token. A hosting location of a connector for the network service is identified based on the authentication data. An authentication header is appended to the service request. The service request with the authentication header is transmitted to the connector.

Abstract: Gas and liquid velocities of fluid in a lift gas assisted well system are estimated by adding liquid and gas tracers downhole and monitoring their travel time over a known distance. Based on estimated velocities, a slip factor is obtained that represents relative velocities of the gas and liquid in the fluid. A flow regime of the fluid is identified based on the slip factor. The flow regime is optionally altered by adjusting one or more operational parameters of the well.

Abstract: Disclosed are various approaches for retrieving contacts from a plurality of federated services. A query is received from a client application executing on a client device, the query comprising a single sign-on token that identifies a user and a character string. A number of federated services that the user has permission to access are then identified. A plurality of authentication tokens are then retrieved from an authentication service, each of the plurality of authentication tokens identifying the user to a respective one of the plurality of federated services. Next, the authentication token and the character string are provided to a respective connector for each of the plurality of federated services that the user has permission to access. A plurality of responses are received, each of the plurality of responses being received from the respective connector corresponding to each of the plurality of federated services that the user has permission to access.

Abstract: A lift gas injection system that is used for introducing lift gas into a stream of production fluid includes a lift gas injection valve. A pressure protection system guards the injection valve against external overpressure by blocking communication to inside the injection valve housing when ambient pressure exceeds a set pressure. Communication is blocked by moving a valve member so that it obstructs flow through an opening in the housing. The system includes pressure actuated valve which has a platen mounted to an end of a bellows, and a valve member coupled to the platen. Surface area is reduced on the bellows side of the platen that creates a force imbalance on the platen from applied ambient pressure. At the set pressure the force imbalance moves the platen, and which pushes the valve member against the opening. A compressible pressure compensator inside the injection valve protects against internal overpressure.