Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: Examples described herein relate to migrating a virtualized execution environment from a first platform to a second platform while retaining use of namespace identifiers and permitting issuance of storage transactions by the virtualized execution environment. The first platform can include a first central processing unit or a first network interface. The second platform can include a central processing unit that is different that the first central processing unit and a network interface that is the same or different than the first network interface. The second platform can retain access permissions and target media format independent of one or more identifiers associated with the migrated virtualized execution environment at the second platform. Unperformed storage transactions can be migrated to the second platform for execution.

Abstract: An aircraft can include a stacked propeller to generate lift during assent and descent. The stacked propeller includes a first propeller and a second propeller that co-rotate about an axis of rotation. In one embodiment, the blades are coupled to a rotor mast that contains an internal cavity. In one mode of operation, the first propeller and/or the second propeller can be stored in the internal cavity in order to reduce drag during flight. The aircraft can include one or more stacked propellers, such as a port propeller and a starboard propeller, which rotate in opposite directions during one or more modes of flight.

Abstract: There is disclosed a system, including apparatus, methods and computer programs, for running native software applications (apps) and HTML5 web-based apps on a computing device, particularly a mobile computing device, in a multitasking mode of operation. In one embodiment, touch screen displays having one or more browsers are adapted to run one or more HTML5 apps, and receive input from hand gestures. One or more software modules execute on the operating system and are responsive to a dragging gesture applied to an HTML5 app displayed in a full screen mode, to subdivide the screen display and display the HTML5 app in one of the subdivided areas and display icons used to launch a second HTML5 app in a different one of the subdivided areas. The second HTML5 app is run concurrently with the first HTML5 app in order to provide multi-tasking between the first and second apps.

Abstract: Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.

Abstract: Disclosed are various approaches for workflow service back end integration. In some examples, a workflow service identifies a workflow action and a user account that is responsible for the workflow action. A command to present the workflow action for user authorization is transmitted to a client device associated with the user account. The workflow service transmits a command to perform the workflow action based on an identification of the user authorization.

Abstract: Disclosed are various approaches for polling federated services for notifications. A request for an access token for a federated service is sent to an authentication service. The access token for the federated service is received from the authentication service. A query is sent to the federated service for a notification, the query comprising the access token. The notification is received from the federated service.

Abstract: A well system having a wellbore that intersects a subterranean formation, a valve station in the wellbore, and a primary controller on surface that communicates with the valve station using wireless telemetry. The valve station includes a valve member that controls a flow of fluid in the wellbore, an actuator for operating the valve member, and a valve controller that provides command signals to the actuator for positioning the valve member. The primary controller sends command signals that are receivable when the telemetry is operational. The valve controller is programmed to control operation of the valve actuator and valve member when telemetry is suspended and so that the valve station operates autonomously when out of signal communication with the primary controller and until signal communication is reestablished.

Abstract: A beverage holder includes a frame, an insert, and a cover. The frame includes a sidewall having an upper end and a lower end, and a bottom wall extending across the lower end. The upper end defines a plurality of protrusions. The sidewall and the bottom wall cooperatively define a chamber. The insert includes a peripheral rim defining a plurality of apertures that receive the plurality of protrusions and a flexible collar extending from the peripheral rim and at least partially into the chamber. The flexible collar defines an opening leading to the chamber. The cover includes a plurality of interfaces that engage with the plurality of protrusions to couple the cover to the upper end of the sidewall and to secure the insert between the frame and the cover. The cover defines an aperture that aligns with the chamber and the opening.

Abstract: A bi-directional valve with valve elements having compliant features biasing them together to maintain a sealing interface that defines a fluid communication barrier within the valve. Parting the valve elements from one another removes the sealing interface allow fluid communication across the valve elements. The valve includes a side port and a choke member that selectively blocks fluid flow through the valve when moved adjacent the side port and selectively opens the valve to fluid communication when moved away from the side port. The choke member remains adjacent the side port until the valve elements are spaced a distance apart greater than that at which valve erosion or fluid cavitation occurs.

Abstract: A bi-directional valve with valve elements having compliant features biasing them together to maintain a sealing interface that defines a fluid communication barrier within the valve. Parting the valve elements from one another removes the sealing interface allow fluid communication across the valve elements. The valve includes a side port and a choke member that selectively blocks fluid flow through the valve when moved adjacent the side port and selectively opens the valve to fluid communication when moved away from the side port. The choke member remains adjacent the side port until the valve elements are spaced a distance apart greater than that at which valve erosion or fluid cavitation occurs. Also included with the valve are systems for counterbalancing forces exerted onto the valve from differential pressures.

Abstract: A graphical user interface is configured to guide a user through a method of creating a RESTful API protocol-compliant URL, without requiring that the user be familiar with syntax of the RESTful API protocol. The graphical user interface includes a URL output that indicates to the user features within a user-edited URL that render the user-edited URL non-compliant with the RESTful API protocol. The graphical user interface includes a set of graphical input devices to solicit and receive from the user input specifying a set of query options, which user input is used to define the RESTful API protocol-compliant URL. The graphical user interface is automatically customized to solicit and receive from the user input only for options available from a specific data service.

Abstract: A first device is configured to establish a connection over a short-range communication link with a second device. The first device may transition to a sleep state, terminate (i) a paging operation and a page scanning operation associated with a paging protocol and (ii) an advertisement scanning operation associated with an advertisement protocol and perform an advertisement broadcast operation associated with the advertisement protocol, the advertisement broadcast operation generating an advertisement to be broadcast at a first interval, wherein the first interval is greater than a second interval for performing advertisement broadcast operations in an active state.

Abstract: A graphical user interface is configured to guide a user through a method of creating a RESTful API protocol-compliant URL, without requiring that the user be familiar with syntax of the RESTful API protocol. The graphical user interface includes a URL output that indicates to the user features within a user-edited URL that render the user-edited URL non-compliant with the RESTful API protocol. The graphical user interface includes a set of graphical input devices to solicit and receive from the user input specifying a set of query options, which user input is used to define the RESTful API protocol-compliant URL. The graphical user interface is automatically customized to solicit and receive from the user input only for options available from a specific data service.

Abstract: A graphical user interface is configured to guide a user through a method of creating a RESTful API protocol-compliant URL, without requiring that the user be familiar with syntax of the RESTful API protocol. The graphical user interface includes a URL output that indicates to the user features within a user-edited URL that render the user-edited URL non-compliant with the RESTful API protocol. The graphical user interface includes a set of graphical input devices to solicit and receive from the user input specifying a set of query options, which user input is used to define the RESTful API protocol-compliant URL. The graphical user interface is automatically customized to solicit and receive from the user input only for options available from a specific data service.

Abstract: A method is disclosed for providing a tuned mass damper for a powertrain component. The method includes the steps of providing a mount adapted to be attached to the powertrain component; assembling a mass element to the mount; and molding an elastomeric body around the mass element to bond the mass element to the mount. The tuned mass damper assembly for a drivetrain component is also disclosed that may be attached to a mount having an opening that extends through the mount or a housing portion provided on the mount The molded elastomeric body integrally attaches the mass element to the mount. Alternatively, the tuned mass assembly may be bonded to a plate that is attached to a motor retention element.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A graphical user interface is configured to guide a user through a method of creating an OData-compliant URL, without requiring that the user be familiar with syntax of OData-compliant URLs. The graphical user interface includes a set of graphical input devices to solicit and receive from the user input specifying a set of query options, which user input is used to define the OData-compliant URL. The graphical user interface is automatically customized to solicit and receive from the user input only for options available from a specific OData service.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A first device is configured to establish a connection over a short-range communication link with a second device. The first device may transition to a sleep state, terminate (i) a paging operation and a page scanning operation associated with a paging protocol and (ii) an advertisement scanning operation associated with an advertisement protocol and perform an advertisement broadcast operation associated with the advertisement protocol, the advertisement broadcast operation generating an advertisement to be broadcast at a first interval, wherein the first interval is greater than a second interval for performing advertisement broadcast operations in an active state.