Patents by Inventor David Siegal

David Siegal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HSP90 inhibitors with modified toxicity
    Patent number: 9603829
    Abstract: The invention provides 19-substituted geldanamycin derivatives, and pharmaceutically acceptable salts thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer or neurodegenerative disorders.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: March 28, 2017
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: David Ross, David Siegal, Christopher J. Moody, Russell Richard Anthony Kitson
  • HSP90 INHIBITORS WITH MODIFIED TOXICITY
    Publication number: 20140315845
    Abstract: The invention provides 19-substituted geldanamycin derivatives, and pharmaceutically acceptable salts thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer or neurodegenerative disorders.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 23, 2014
    Inventors: David Ross, David Siegal, Christopher J. Moody, Russell Richard Anthony Kitson
  • Method for applying NMR for ligand discovery or as a drug screening tool
    Patent number: 8173441
    Abstract: The present invention relates to a method for screening compounds to identify compounds that bind to a specific target, comprising the steps of: (a) providing a target immobilized to a solid support; (b) generating a first NMR spectrum of the said compounds to be screened in the presence of the solid support without the target molecule immobilized thereto; (c) generating a second NMR spectrum of the said compounds to be screened in the presence of the solid support with the target molecule immobilized thereto; and (d) comparing said first and second NMR spectrum to determine differences between said first and second NMR spectrum. Further the invention relates to an NMR apparatus having arranged therein a particular NMR probe.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: May 8, 2012
    Assignee: Universiteit Leiden
    Inventor: Gregg David Siegal
  • Method for applying nmr for ligand discovery or as a drug screening tool
    Publication number: 20030148297
    Abstract: The present invention relates to a method for screening compounds to identify compounds that bind to a specific target, comprising the steps of: (a) providing a target immobilized to a solid support; (b) generating a first NMR spectrum of the said compounds to be screened in the presence of the solid support without the target molecule immobilized thereto; (c) generating a second NMR spectrum of the said compounds to be screened in the presence of the solid support with the target molecule immobilized thereto; and (d) comparing said first and second NMR spectrum to determine differences between said first and second NMR spectrum. Further the invention relates to an NMR apparatus having arranged therein a particular NMR probe.
    Type: Application
    Filed: August 26, 2002
    Publication date: August 7, 2003
    Inventor: Gregg David Siegal