Patents by Inventor David Singel

David Singel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8499330
    Abstract: A method for desktop enterprise security management that addresses the multiple network and desktop security needs of an enterprise, facilitates the development, implementation, and enforcement of the enterprise's desktop security policies and procedures, and provides for review and revision of those policies and procedures. The method is based on a four-stage approach to desktop network security management. The first stage lays the foundation for the enterprise's network security policy. The second stage validates users and desktop devices according to the enterprise's desktop security policies, gathers data, and provides feedback to users regarding their compliance with the enterprise's desktop security policies. The third stage enforces the enterprise's desktop security policies by blocking access by desktop devices and/or users that do not comply with the enterprise's desktop security policies.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: July 30, 2013
    Assignee: AT&T Intellectual Property II, L.P.
    Inventors: Luis F. Albisu, Patricia M. DeVere, Walter J. Gula, David A. Singel
  • Patent number: 7157500
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: January 2, 2007
    Assignee: Brigham and Women's Hospital
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel
  • Publication number: 20060252671
    Abstract: Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body is converted to a hemoglobin capable of nitric oxide delivery and provides vasodilator and antiplatelet activity. This provides basis for ameliorated risk blood product transfusions.
    Type: Application
    Filed: December 10, 2003
    Publication date: November 9, 2006
    Inventors: Jonathan Stamler, David Singel
  • Publication number: 20060198831
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Application
    Filed: May 5, 2006
    Publication date: September 7, 2006
    Applicant: Brigham and Women's Hospital
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel
  • Patent number: 6562344
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: May 13, 2003
    Assignee: Brigham and Women's Hospital
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel
  • Publication number: 20030007967
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Application
    Filed: August 13, 2002
    Publication date: January 9, 2003
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel
  • Patent number: 5863890
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: January 26, 1999
    Assignee: Brigham and Women's Hospital
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel
  • Patent number: 5593876
    Abstract: Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use of S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: January 14, 1997
    Assignee: Brigham and Women's Hospital
    Inventors: Jonathan Stamler, Joseph Loscalzo, Daniel Simon, David Singel