Patents by Inventor David Skibinski

David Skibinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination vaccines with lower doses of antigen and/or adjuvant
    Patent number: 10603369
    Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 31, 2020
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Barbara Baudner, David Skibinski, Manmohan Singh, Derek O'Hagan
  • COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT
    Publication number: 20180169204
    Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Applicant: GlaxoSmithKline Biologicals SA
    Inventors: Barbara BAUDNER, David SKIBINSKI, Manmohan SINGH, Derek O'HAGAN
  • Compounds and compositions as TLR activity modulators
    Patent number: 9950062
    Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: April 24, 2018
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Manmohan Singh, David Skibinski, Simona Cianetti, Francesco Doro, Siddhartha Jain
  • Flow cytometry analysis of materials adsorbed to metal salts
    Patent number: 9618508
    Abstract: The invention utilizes the techniques and instruments which are typically used in flow cytometry (FC) as a tool for analyzing adsorbed materials. Thus the invention provides a method for analyzing a component which is adsorbed to an insoluble metal salt, comprising steps of: (i) labelling the adsorbed component with a binding reagent; and (ii) analyzing the labelled adsorbed component by flow cytometry.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: April 11, 2017
    Assignee: GlaxoSmithKline Biologicals SA
    Inventors: David Skibinski, Donatello Laera, Sandra Nuti, Mildred Ugozzoli
  • HOMOGENOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF
    Publication number: 20160375132
    Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
    Type: Application
    Filed: July 5, 2016
    Publication date: December 29, 2016
    Inventors: David Skibinski, Siddhartha Jain, Manmohan Singh, Derek O'Hagan
  • Homogenous suspension of immunopotentiating compounds and uses thereof
    Patent number: 9408907
    Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: August 9, 2016
    Assignee: GlaxoSmithKline Biologicals SA
    Inventors: David Skibinski, Siddhartha Jain, Manmohan Singh, Derek O'Hagan
  • COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
    Publication number: 20150225432
    Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
    Type: Application
    Filed: April 24, 2015
    Publication date: August 13, 2015
    Applicant: Novartis AG
    Inventors: Alex Cortez, Yongkai Li, Manmohan Singh, David Skibinski, Kathy Yue, Tom Yao-Hsiang Wu, Xiaoyue Zhang
  • Compounds and compositions as TLR activity modulators
    Patent number: 9045470
    Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: June 2, 2015
    Assignee: IRM LLC
    Inventors: Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Kathy Yue, Xiaoyue Zhang, Manmohan Singh, David Skibinski
  • COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT
    Publication number: 20140112950
    Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
    Type: Application
    Filed: March 2, 2012
    Publication date: April 24, 2014
    Inventors: Manmohan Singh, Barbara Baudner, David Skibinski
  • FLOW CYTOMETRY ANALYSIS OF MATERIALS ADSORBED TO METAL SALTS
    Publication number: 20130330840
    Abstract: The invention utilises the techniques and instruments which are typically used in flow cytometry (FC) as a tool for analysing adsorbed materials. Thus the invention provides a method for analysing a component which is adsorbed to an insoluble metal salt, comprising steps of: (i) labelling the adsorbed component with a binding reagent; and (ii) analysing the labelled adsorbed component by flow cytometry.
    Type: Application
    Filed: December 14, 2011
    Publication date: December 12, 2013
    Applicant: NOVARTIS AG
    Inventors: David Skibinski, Donatello Laera, Sandra Nuti, Mildred Ugozzoli
  • Compounds and compositions as TLR activity modulators
    Patent number: 8466167
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4?CR5.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: June 18, 2013
    Assignees: IRM LLC, Novartis AG
    Inventors: Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Yefen Zou, Pranab Mishra, Xiaoyue Zhang, David Skibinski, Manmohan Singh, Nicholas Valiante
  • HOMOGENOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF
    Publication number: 20130101629
    Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
    Type: Application
    Filed: December 15, 2010
    Publication date: April 25, 2013
    Applicant: NOVARTIS AG
    Inventors: David Skibinski, Siddhartha Jain, Manmohan Singh, Derek O'Hagan
  • COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
    Publication number: 20120237546
    Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
    Type: Application
    Filed: September 1, 2010
    Publication date: September 20, 2012
    Applicant: Novartis AG
    Inventors: Manmohan Singh, David Skibinski, Simona Cianetti, Francesco Doro, Siddhartha Jain
  • COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
    Publication number: 20110081365
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4?CR5.
    Type: Application
    Filed: February 27, 2009
    Publication date: April 7, 2011
    Applicants: IRM LLC, Novartis 35
    Inventors: Alex Cortez, Yongkai Li, Pranab Mishra, Manmohan Singh, David Skibinski, Nicholas Valiante, Tom Yao-Hsiang Wu, Xiaoyue Zhang, Yefen Zou
  • COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
    Publication number: 20110053893
    Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 3, 2011
    Applicants: IRM LLC, Novartis AG
    Inventors: Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Kathy Yue, Xiaoyue Zhang, Manmohan Singh, David Skibinski