Abstract: A pair of glasses, advantageously used as safety glasses in a manufacturing environment, which includes a novel metal clip component which is securely embedded in a portion of such glasses. In preferred embodiments, the inventive metal clip component is roughly U-shaped with ridges at each tip thereof, such that the inventive metal clip is securely fixed at a given location within said safety glasses upon being applied and cannot back out or be loosened under conditions of normal use.

Abstract: A packing assembly includes a packing sleeve having a first sleeve portion and a second sleeve portion, wherein a first sleeve portion outer diameter is larger than a second sleeve portion outer diameter and a first sleeve portion inner diameter is larger than a second sleeve portion inner diameter. The packing assembly also includes a groove formed in the second sleeve portion outer diameter. The packing assembly further includes a shoulder formed at a transition between the first sleeve portion and the second sleeve portion. The packing assembly includes a shelf formed at the transition between the first sleeve portion and the second sleeve portion. The packing assembly also includes a plurality of packing components arranged within the first sleeve portion inner diameter, at least a portion of the plurality of packing components engaging the shelf. The packing assembly further includes a seal positioned within the groove.

Abstract: The specification relates to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for use in the treatment of cancer, wherein the EGFR TKI is administered in combination with an AKT inhibitor.

Abstract: The present invention provides a series of 2,4-dioxotetrahydropyrimidinyl derivatives that bind cereblon, and their application as degrons in PROTACs. Androgen receptor PROTACs containing the 2,4-dioxotetrahydropyrimidinyl containing degrons and medical uses of these PROTACS are also disclosed.

Abstract: A measurement system comprising: power converter circuitry; and measurement circuitry, wherein the measurement circuitry is operative to control a timing of a refresh of the power converter circuitry so as to avoid conflict with a measurement operation.

Abstract: In a digital image annotation and retrieval system, a machine learning model identifies an image feature in an image and generates a plurality of question prompts for the feature. For a particular feature, a feature annotation is generated, which can include capturing a narrative, determining a plurality of narrative units, and mapping a particular narrative unit to the identified image feature. An enriched image is generated using the generated feature annotation. The enriched image includes searchable metadata comprising the feature annotation and the plurality of question prompts.

Abstract: The present disclosure relates to an input for production of atomizers and atomizers formed from a sheet of a material, and which may be employed in an aerosol delivery device such as a smoking article. The input may include a carrier and heating elements coupled thereto. The heating elements may include first and second ends and interconnected alternating loops disposed therebetween. The heating elements may be oriented parallel to a longitudinal axis of the carrier, or perpendicular thereto. The heating elements may be coupled to a liquid transport element by bending the interconnected loops at least partially around the liquid transport element. The ends of the heating element may be coupled to heater terminals. A related method for forming atomizers is also provided.

Abstract: A method of monitoring contactor health for an electrical contactor of an electric apparatus, the electrical contactor being switchable in a switching event between an open state and a closed state or between a closed state and an open state. In response to a switching event instruction the method comprises determining a current value indicative of current flowing in the electrical contactor in the closed state at a time proximate to the switching event; attributing a percentage of a total contactor life estimate to the switching event based on the current value; determining an updated remaining percentage contactor life estimate by subtracting the percentage of total contactor life estimate from an initial remaining percentage contactor life estimate; and outputting the updated remaining percentage contactor life estimate.

Abstract: A user content protection system and method that may include a content-sharing application associated with a user device and/or an access monitor configured to monitor access limitations placed on content shared by the content sharing application. The content-sharing application may be configured to share content from the user device to one or more other user devices. The access monitor may provide conditional access to the content depending on whether or not certain access limitations have been exceeded.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: There is disclosed an apparatus for mooring a structure and/or tensioning a mooring line. The apparatus comprises: a guide portion for guiding a portion of a first mooring line, and a lock arrangement, wherein the apparatus provides a mooring line path, the lock arrangement being provided on an opposite side of the mooring line path from the guide portion, at least when the lock arrangement is in an unlocked configuration. When in a locked configuration at least a portion of the lock arrangement is provided in the mooring path.

Abstract: A method includes identifying map data comprising driving constraint data for a route of an autonomous vehicle (AV), the map data being of a road network associated with the route of the AV, the driving constraint data being based on physical vehicle data. The method further includes, while the AV is travelling the route, identifying current environmental sensing data for a portion of the route. The method further includes causing, based on the map data comprising the driving constraint data for the route and the current environmental sensing data associated with the portion of the route, the AV to travel the portion of the route.

Abstract: Systems and methods for servicing read requests may include receiving a transaction from a processing unit while mirroring contents from an external memory to an on-chip RAM. Such systems and methods may monitor a progress of the mirroring and, based on the monitoring, access code or data values for the transaction from either the external memory or the on-chip RAM. Such systems and methods may further provide the code or data values to the processing unit according to the transaction. Such systems and methods may allow for execution of software before software has been fully downloaded to internal memory.

Abstract: An example article according to the present disclosure includes, among other possible things, a metallic substrate, and a bond coat on the metallic substrate. The bond coat includes a matrix phase, gettering particles in the matrix phase, wherein the gettering particles are reactive with oxidants, and a dispersion of matrix modifier particles in the matrix phase. The example article also includes a diffusion barrier between the bond coat and the metallic substrate, wherein the diffusion barrier is configured to inhibit diffusion of components from the bond coat into the metallic substrate. An example composite material and method of applying a barrier to a substrate are also disclosed.

Abstract: A valve assembly includes an upper portion to be coupled to guide legs, a cavity being formed within one of the upper portion or the guide legs and a coupling member being associated with the other of the upper portion or the guide legs, wherein the upper portion is coupled to the guide legs via a single force application process.

Abstract: A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

Abstract: In one example in accordance with the present disclosure, a fluid ejection system is described. The fluid ejection system includes a frame to retain a number of fluid ejection devices. Each fluid ejection device includes a reservoir disposed on a first side of the frame and a fluid ejection die disposed on an opposite side of the frame. Each fluid ejection die includes 1) a fluid feed slot formed in a substrate to receive fluid from the reservoir, 2) an array of nozzles formed in the substrate to eject fluid, and 3) an ejection adjustment system to selectively adjust an amount of fluid ejected from the fluid ejection devices.

Abstract: One aspect of the disclosure includes a fluid moving system. The fluid moving system includes a fluid moving apparatus configured to convey a fluid through a housing from an inlet to an outlet. The fluid moving system includes an active cleaning device configured to neutralize or remove at least a portion of an undesired matter from the fluid conveyed through the housing. The fluid moving system includes an electric motor including a rotor coupled to the fluid moving apparatus and configured to turn the fluid moving apparatus upon application of electric power to a stator of the electric motor. The fluid moving system includes a motor controller communicatively coupled to the electric motor and configured to control at least one of a speed output or a torque output thereof.

Abstract: A method includes identifying suspension stiffness data and suspension deflection data associated with corresponding distal ends of one or more axles of an autonomous vehicle (AV). The method further includes determining, based on the suspension deflection data and the suspension stiffness data, driving constraint data for traveling at least a portion of a route. The method further includes causing, based on the driving constraint data, performance of a corrective action associated with the AV during the traveling of the at least a portion of a route.