Abstract: A computer-implemented method is provided of analysing an image of a tissue specimen, which method comprises steps including detecting in the image each of a primary type of biological entity, detecting in the image one or more secondary types of biological entity, associated with each of the detected primary biological entities, generating an entity graph, in which each graph node is assigned to a primary biological entity, and in which each graph node is associated with predictive features measured from the image in respect of that graph node, including at least one predictive feature that is measured relative to two or more types of biological entity.

Abstract: The present invention relates to methods for separating enantiomers of 5-phenyl and 5-naphthyl substituted 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl)phthalazin-1(2H)-ones using N-Boc-L-phenylalanine, N-Boc-D-phenylalanine, and similar chiral acids.

Abstract: The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.

Abstract: A system for assembling a cabinet which includes a first base member having a first length and a base member channel extending the first length of the base member. The system includes a second base member having a second length, a second base member channel extending the second length of the second base member, a pair of opposing secondary members each having a third length and a secondary member channel extending the third length of the secondary members and a first cap member disposable in the base member channel. The system includes a first and second locking member disposable in each of the secondary member channels, the locking member extending from the first base member to the second base member when the cabinet is fully assembled. The locking members are engagable with the first and second base member channel for securing the secondary members to first and second base members.

Abstract: A system for assembling a cabinet which includes a first base member having a first length and a base member channel extending the first length of the base member. The system includes a second base member having a second length, a second base member channel extending the second length of the second base member, a pair of opposing secondary members each having a third length and a secondary member channel extending the third length of the secondary members and a first cap member disposable in the base member channel. The system includes a first and second locking member disposable in each of the secondary member channels, the locking member extending from the first base member to the second base member when the cabinet is fully assembled. The locking member are engagable with the first and second base member channel for securing the secondary members to first and second base members.