Abstract: A molecular assembly having a structural formation of amphiphilic molecules is disclosed where the amphiphilic molecules are selected from a group containing amphiphilic molecules which a) have a hydrophobic moiety and a hydrophilic moiety b) are soluble in a polar aprotic solvent and form self-organizing layer structures in the absence of the polar aprotic solvent, and c) orient molecularly in formed layer structures at an interfacial layer, or in an aqueous environment. The amphiphilic molecules in the formed layer structure are in contact with an aqueous environment. A method for coating a solid surface with a molecular assembly is also disclosed, wherein the amphiphilic molecules are dissolved in a polar aprotic solvent, and resulting solution is applied to a solid surface by spin coating.

Abstract: Aspects of the invention described herein concern the incorporation of a FOXP3 cDNA (e.g., full-length human codon-optimized cDNA) into a FOXP3 gene or a non-FOXP3 locus so as to provide constitutive or regulated FOXP3 expression in a primary human CD34+ cells or cells derived from edited CD34+ cells. In some embodiments, guide RNA sequences that are directed to FOXP3, AAVS1, or other candidate loci are used for CRISPR/Cas9-mediated gene regulation, and gene delivery cassettes for HDR based gene-modification are provided.

Abstract: A hairbrush may include a head portion, a handle extending from the head portion, and a cushion selectively coupleable with the head portion. The cushion is configured to be selectively loaded with one or more bristle bars, and each bristle bar may contain one or more bristles extending therefrom. The cushion may include a plurality of bristle openings arranged in rows. Each row of bristle openings can be loaded with no bristle bars, one bristle bar, or two bristle bars. When a row of openings in the cushion is loaded with two bristle bars, the two bristle bars are interlocked with one another along their respective lengths.

Abstract: A hairbrush may include a head portion, a handle extending from the head portion, and a cushion selectively coupleable with the head portion. The cushion is configured to be selectively loaded with one or more bristle bars, and each bristle bar may contain one or more bristles extending therefrom. The cushion may include a plurality of bristle openings arranged in rows. Each row of bristle openings can be loaded with no bristle bars, one bristle bar, or two bristle bars. When a row of openings in the cushion is loaded with two bristle bars, the two bristle bars are interlocked with one another along their respective lengths.

Abstract: A vehicle lock includes a locking mechanism with a rotary latch and a pawl for latching the rotary latch when the vehicle lock is in a closed state, a receiver for receiving a reference code, a code transfer interface for obtaining an access code and a control unit which is configured such that the vehicle lock assumes an unlocked state when the obtained access code matches the reference code. The locking mechanism is used in a method for access-controlled loading and/or unloading of a vehicle. A high degree of automation of an access-controlled process for loading and/or unloading a vehicle can thus be achieved substantially with the aid of the vehicle lock.

Abstract: A hair brush may include a body, a number of bristles extending away from the body, and a replaceable cartridge removably attached to the body. The cartridge may include a housing, a reservoir positioned at least partially within the housing, and an applicator positioned at least partially within the housing. The reservoir may be configured to store a hair care treatment therein and may include a first porous material. The applicator may be configured to apply the hair care treatment to hair of a user and may include a second porous material. The hair care treatment may be optimized for delivery via the reservoir and the applicator.

Abstract: Values of a variable affecting the determination of the driver of a shared ride may be calculated. Each value may be associated with a respective potential driver. An optimal value from the calculated values may be selected. A potential driver associated with the selected optimal value may be assigned as the driver of the shared ride. The variable may be carbon emission, electricity consumption, passenger to driver role ratio, driving distance, driving time, vehicle size, fuel efficiency, electricity to gasoline usage ratio, accident occurrence, vehicle safety, vehicle comfort, or vehicle speed. The optimal value may be the lowest value or the highest value from the calculated values. Each value may be calculated based on parameters specified by the respective potential driver.

Abstract: Embodiments of the present invention may provide a various techniques for raising user satisfaction with an automated ride sharing system. In one embodiment, the system may disqualify potential passengers that will force the driver to return to a previously departed area. In another embodiment, the system may consolidate multiple stop locations to reduce the number and frequency of stops in a scheduled ride. In another embodiment, the system may select a best possible ride from a plurality of calculated rides based on user satisfaction factors.

Abstract: Values of a variable affecting the determination of the driver of a shared ride may be calculated. Each value may be associated with a respective potential driver. An optimal value from the calculated values may be selected. A potential driver associated with the selected optimal value may be assigned as the driver of the shared ride. The variable may be carbon emission, electricity consumption, passenger to driver role ratio, driving distance, driving time, vehicle size, fuel efficiency, electricity to gasoline usage ratio, accident occurrence, vehicle safety, vehicle comfort, or vehicle speed. The optimal value may be the lowest value or the highest value from the calculated values. Each value may be calculated based on parameters specified by the respective potential driver.

Abstract: A time difference between a segment belonging to a multi-segment ride and a ride intent may be calculated. The time difference may be compared to a threshold. If the time difference is less than or equal to the threshold, the ride intent may be marked as a new segment of the multi-segment ride. The parameters of the segment belonging to the multi-segment ride and the ride intent may be specified through electronic calendar entries. The segment belonging to the multi-segment ride may be the first temporal segment of the multi-segment ride.

Abstract: A backend carpooling system including a memory device, a processing device, a communication device, a calculating arrangement, coupled to the memory and processing devices, that includes one or more algorithms for calculating distances, travel times, routes, and performing optimizations to select a distance, travel time, or route satisfying predetermined optimization criteria, the calculating arrangement generating a plurality of ridesharing opportunities, and a notification arrangement, coupled to the communication device, that transmits the plurality of ridesharing opportunities to a user, wherein the plurality of ridesharing opportunities are periodically transmitted to the user.

Abstract: The invention relates to a method for integrating services in a calendar application via the meeting request functionality of calendar programs comprising: initiating one or multiple services, wherein the initiation may involve the transmission of calendar event information from the calendar application to the service, the service requests being sent as meeting request e-mails to one or more service e-mail addresses, each service e-mail address representing a service, receiving the update requests generated by the one or multiple services, the update requests being meeting request response e-mails or one or multiple second meeting request e-mails processing the received update requests, and updating the calendar application.

Abstract: A method and system for allocating users as trip accompanies provides for: creating a first trip prediction algorithm, collecting input parameters, predicting by the first trip prediction algorithm using the collected input parameters as input, at least one first trip, executing a matching method, the matching method comparing attributes of the predicted at least one first trip with attributes of at least one second trip, and allocating the first and the second user to each other as trip accompanies in dependence of the matching score of the first and second potential trip data object.

Abstract: Embodiments of the present invention may provide a various techniques for raising user satisfaction with an automated ride sharing system. In one embodiment, the system may disqualify potential passengers that will force the driver to return to a previously departed area. In another embodiment, the system may consolidate multiple stop locations to reduce the number and frequency of stops in a scheduled ride. In another embodiment, the system may select a best possible ride from a plurality of calculated rides based on user satisfaction factors.