Patents by Inventor David Sperandio

David Sperandio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolo[1,5-a]pyrimidines for antiviral treatment
    Patent number: 8486938
    Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 16, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Kerim Babaoglu, Constantine G. Boojamra, Eugene J. Eisenberg, Hon Chung Hui, Richard L. Mackman, Jay P. Parrish, Michael Sangi, Oliver L. Saunders, Dustin Siegel, David Sperandio, Hai Yang
  • Nucleoside analogs for antiviral treatment
    Patent number: 8324179
    Abstract: The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically acceptable salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: December 4, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Alan X. Huang, Richard L. Mackman, Jay Parrish, Jason K. Perry, Oliver L. Saunders, David Sperandio
  • ANTI-RSV COMPOUNDS
    Publication number: 20120196846
    Abstract: The present invention relates to anti-RSV compounds of Formula (I) and methods for use of the compounds in the treatment and prevention of RSV infection.
    Type: Application
    Filed: July 7, 2010
    Publication date: August 2, 2012
    Applicant: Gilead Sciences, Inc.
    Inventors: Richard L. Mackman, David Sperandio, Hai Yang
  • PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
    Publication number: 20120003215
    Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 5, 2012
    Applicant: Gilead Sciences, Inc.
    Inventors: Kerim Babaoglu, Constantine G. Boojamra, Eugene J. Eisenberg, Hon Chung Hui, Richard L. Mackman, Jay P. Parrish, Michael Sangi, Oliver L. Saunders, Dustin Siegel, David Sperandio, Hai Yang
  • PTAC LOUVER
    Publication number: 20100317281
    Abstract: A PTAC louver assembly for glazing in a window wall which is field adjustable for fastening to a PTAC sleeves provided by different manufacturers. A unique system includes inwardly directed flanges which form a box within a box when mated to the PTAC sleeve. Sealant between the flanges and the PTAC sleeve provide a substantially water tight assembly. By sealing between the sleeve and the lower sill flange, the need to seal the sleeve face and to align weep holes in the PTAC sleeve is no longer necessary. Blank-off panels are filled with high temperature insulation which allows the louver system to be painted and baked after assembly. A unique louver blade assembly uses sliding retention bars with aligned notches to receive and capture louver blades using a clamping force.
    Type: Application
    Filed: June 14, 2010
    Publication date: December 16, 2010
    Inventors: David Sperandio, David Szydioski
  • NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
    Publication number: 20100104532
    Abstract: The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
    Type: Application
    Filed: February 8, 2008
    Publication date: April 29, 2010
    Applicant: GILEAD SCIENCES, INC.
    Inventors: James M. Chen, Alan X. Huang, Richard L. Mackman, Jay Parrish, Jason K. Perry, Oliver L. Saunders, David Sperandio
  • 2-[5-(5-Carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-YL]-succinic acid derivatives as factor viia inhibitors
    Publication number: 20050176797
    Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.
    Type: Application
    Filed: September 13, 2004
    Publication date: August 11, 2005
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Huiyong Hu, John Hendrix, Aleksandr Kolesnikov, Roopa Rai, William Shrader, David Sperandio, Wendy Young, Steven Torkelson
  • 3,4-Dihydroisoquinolin-1-one derivatives as inducers of apoptosis
    Publication number: 20050124614
    Abstract: The present invention related to certain 3,4-dihydroisoquinolin-1-ones that are activators of caspases and inducers of apoptosis, pharmaceutical composition comprising these compounds, and method of treating cancer utilizing these compounds.
    Type: Application
    Filed: July 3, 2003
    Publication date: June 9, 2005
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Anthony Gangloff, Joane Litvak, Keith Pararajasingham, David Sperandio
  • Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Patent number: 6861419
    Abstract: The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I: wherein the dashed lines, A1, A2, A3, X1 and R1 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of capases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: March 1, 2005
    Assignee: Cytovia, Inc.
    Inventors: John A. Drewe, Sui Xiong Cai, Emma Jane Shelton, Joane Litvak, David Sperandio, Jeffrey R. Spencer, Martin Sendzik
  • Novel phenyl derivatives as inducers of apoptosis
    Publication number: 20050026929
    Abstract: The present invention related to certain phenyl derivatives that are activators of caspases and inducers of apoptosis, pharmaceutical composition comprising these compounds and method of treating cancer utilizing these compounds.
    Type: Application
    Filed: April 23, 2003
    Publication date: February 3, 2005
    Applicants: AXYS PHARMACEUTICALS, INC., CYTOVIA, INC.
    Inventors: Sui Cai, Ben Cebon, Joane Litvak, Keith Pararajasingham, Emma Shelton, Jeffrey Spencer, David Sperandio, Paul Sprengeler, Vincent Tai, Robert Yee
  • 2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors
    Publication number: 20030114457
    Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.
    Type: Application
    Filed: July 3, 2002
    Publication date: June 19, 2003
    Applicant: Axys Pharmaceuticals, Inc.
    Inventors: Huiyong Hu, John Hendrix, Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, David Sperandio, Wendy Young, Steve Torkelson
  • Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof
    Publication number: 20020010169
    Abstract: The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I: 1
    Type: Application
    Filed: April 18, 2001
    Publication date: January 24, 2002
    Applicant: Cytovia, Inc.
    Inventors: John A. Drewe, Sui Xiong Cai, Emma Jane Shelton, Joane Litvak, David Sperandio, Jeffrey R. Spencer