Abstract: In one embodiment, a catheter includes a shaft assembly having a proximal and distal end, which comprises a deflectable segment including lumens running longitudinally therein, electrodes disposed at the distal end, a connector disposed at the proximal end for coupling to processing circuitry, cables disposed in first respective ones of the lumens, each cable electrically coupled to the connector and a respective group of the electrodes, wherein each cable includes a bundle of wires, each wire connected to a respective one of the electrodes in the respective group, an electrical shielding surrounding the bundle, and an electrically insulating jacket surrounding the shielding and sized to allow longitudinal movement of the respective cable within the respective lumen, respective elongated members disposed in second respective ones of the lumens, and connected to the distal end, and a manipulator connected to the elongated members to actuate the distal end via the elongated members.

Abstract: One embodiment includes a catheter apparatus, including an elongated deflectable element including a distal end, a coupler connected to the distal end, a pusher including a distal portion, and configured to be advanced and retracted through the deflectable element, a nose connector connected to the distal portion, and including a distal receptacle having an inner surface and a distal facing opening, and an expandable assembly including flexible polymer circuit strips, each strip including electrodes disposed thereon, the strips being disposed circumferentially around the distal portion of the pusher, with first ends of the strips being connected to the coupler and second ends of the strips including respective hinges entering the distal facing opening and connected to the inner surface of the distal receptacle, the strips being configured to bow radially outward when the pusher is retracted expanding the expandable assembly from a collapsed form to an expanded form.

Abstract: One embodiment includes a catheter apparatus, including an elongated deflectable element including a distal end, a coupler connected to the distal end, a pusher including a distal portion, and configured to be advanced and retracted through the deflectable element, a nose connector connected to the distal portion, and including a distal receptacle having an inner surface and a distal facing opening, and an expandable assembly including flexible polymer circuit strips, each strip including electrodes disposed thereon, the strips being disposed circumferentially around the distal portion of the pusher, with first ends of the strips being connected to the coupler and second ends of the strips including respective hinges entering the distal facing opening and connected to the inner surface of the distal receptacle, the strips being configured to bow radially outward when the pusher is retracted expanding the expandable assembly from a collapsed form to an expanded form.

Abstract: Embodiments of the present invention include a medical probe having an insertion tube, a basket assembly, an axial electrode, and a plurality of radial electrodes. The insertion tube is configured for insertion into a body cavity of a patient. The basket assembly has a proximal end that is connected distally to the insertion tube and includes a plurality of resilient spines, which are configured to bow radially outward from an axis of the basket assembly and are conjoined at a distal end of the basket assembly. The axial electrode is disposed at the distal end of the basket assembly, having a diameter of at least 1.5 millimeters, and is configured to contact tissue in the body cavity. The plurality of radial electrodes are configured to contact the tissue in the body cavity and include radial electrodes disposed on the spines.

Abstract: A medical probe includes a shaft, an expandable membrane and a probe maneuvering assembly (PMA). The shaft is configured for insertion into a cavity of an organ of a patient. The PMA is located inside the expandable membrane and includes a first elastic element, which is fitted along a longitudinal axis of the PMA and is configured to expand the membrane by shortening the PMA, and to collapse the membrane by elongating the PMA. The PMA further includes a second elastic element, which surrounds at least a portion of the first elastic element and is configured to deflect the membrane relative to the longitudinal axis.

Abstract: A low-power mobile telephony alert system and an alert device. The alert device has a communication interface configured to establish a low-power communication link with a mobile device for transmitting status data to the mobile device, and a telephony-enabled communication linked with the mobile device for initiating telephony from the mobile device while in locked mode. The alert device can initiate a status check request to third party contact devices before escalating to connect to the mobile device from locked mode to initiate telephony to an emergency service. The alert device is compact and can be incorporated into an article of jewelry or a wearable loop member.

Abstract: Embodiments of the present invention include a medical probe having an insertion tube, a basket assembly, an axial electrode, and a plurality of radial electrodes. The insertion tube is configured for insertion into a body cavity of a patient. The basket assembly has a proximal end that is connected distally to the insertion tube and includes a plurality of resilient spines, which are configured to bow radially outward from an axis of the basket assembly and are conjoined at a distal end of the basket assembly. The axial electrode is disposed at the distal end of the basket assembly, having a diameter of at least 1.5 millimeters, and is configured to contact tissue in the body cavity. The plurality of radial electrodes are configured to contact the tissue in the body cavity and include radial electrodes disposed on the spines.

Abstract: A low-power mobile telephony alert system and an alert device. The alert device has a communication interface configured to establish a low-power communication link with a mobile device for transmitting status data to the mobile device, and a telephony-enabled communication linked with the mobile device for initiating telephony from the mobile device while in locked mode. The alert device can initiate a status check request to third party contact devices before escalating to connect to the mobile device from locked mode to initiate telephony to an emergency service. The alert device is compact and can be incorporated into an article of jewelry or a wearable loop member.

Abstract: A medical probe includes an insertion tube for insertion into a patient body, at least an arm, which is attached to a distal end of the insertion tube, at least a reference electrode coupled to the arm, and multiple electrodes, which are coupled to the arm, surround the reference electrode and are configured to sense electrical signals of body tissues that, when measured relatively to the reference electrode, are indicative of anatomical signals in the patient body.

Abstract: Laser processing systems and methods are capable of moving a laser beam while maintaining consistent laser beam characteristics at processing locations. The laser processing systems generate a collimated laser beam having a consistent Z axis power density along at least a portion of a length of the laser beam and dither the collimated laser beam along one of the X and Y axes. The dithering of the collimated laser beam facilitates consistent laser processing on a three-dimensional surface, for example, to provide consistent deposition of a coating in a laser cladding process. A laser processing system may include a beam delivery system that provides both the collimation and the dithering of the collimated laser as well as an adjustment of the beam diameter of the collimated beam.

Abstract: A low-power mobile telephony alert system and an alert device. The alert device has a communication interface configured to establish a low-power communication link with a mobile device for transmitting status data to the mobile device, and a telephony-enabled communication linked with the mobile device for initiating telephony from the mobile device while in locked mode. The alert device can initiate a status check request to third party contact devices before escalating to connect to the mobile device from locked mode to initiate telephony to an emergency service. The alert device is compact and can be incorporated into an article of jewelry or a wearable loop member.

Abstract: A medical probe includes a shaft, an expandable membrane and a probe maneuvering assembly (PMA). The shaft is configured for insertion into a cavity of an organ of a patient. The PMA is located inside the expandable membrane and includes a first elastic element, which is fitted along a longitudinal axis of the PMA and is configured to expand the membrane by shortening the PMA, and to collapse the membrane by elongating the PMA. The PMA further includes a second elastic element, which surrounds at least a portion of the first elastic element and is configured to deflect the membrane relative to the longitudinal axis.

Abstract: One embodiment includes a catheter apparatus, including an elongated deflectable element including a distal end, a coupler connected to the distal end, a pusher including a distal portion, and configured to be advanced and retracted through the deflectable element, a nose connector connected to the distal portion, and including a distal receptacle having an inner surface and a distal facing opening, and an expandable assembly including flexible polymer circuit strips, each strip including electrodes disposed thereon, the strips being disposed circumferentially around the distal portion of the pusher, with first ends of the strips being connected to the coupler and second ends of the strips including respective hinges entering the distal facing opening and connected to the inner surface of the distal receptacle, the strips being configured to bow radially outward when the pusher is retracted expanding the expandable assembly from a collapsed form to an expanded form.

Abstract: In one embodiment, a catheter includes a shaft assembly having a proximal and distal end, which comprises a deflectable segment including lumens running longitudinally therein, electrodes disposed at the distal end, a connector disposed at the proximal end for coupling to processing circuitry, cables disposed in first respective ones of the lumens, each cable electrically coupled to the connector and a respective group of the electrodes, wherein each cable includes a bundle of wires, each wire connected to a respective one of the electrodes in the respective group, an electrical shielding surrounding the bundle, and an electrically insulating jacket surrounding the shielding and sized to allow longitudinal movement of the respective cable within the respective lumen, respective elongated members disposed in second respective ones of the lumens, and connected to the distal end, and a manipulator connected to the elongated members to actuate the distal end via the elongated members.

Abstract: A medical probe includes an insertion tube for insertion into a patient body, at least an arm, which is attached to a distal end of the insertion tube, at least a reference electrode coupled to the arm, and multiple electrodes, which are coupled to the arm, surround the reference electrode and are configured to sense electrical signals of body tissues that, when measured relatively to the reference electrode, are indicative of anatomical signals in the patient body.

Abstract: A medical probe includes a shaft, an expandable membrane and a probe maneuvering assembly (PMA). The shaft is configured for insertion into a cavity of an organ of a patient. The PMA is located inside the expandable membrane and includes a first elastic element, which is fitted along a longitudinal axis of the PMA and is configured to expand the membrane by shortening the PMA, and to collapse the membrane by elongating the PMA. The PMA further includes a second elastic element, which surrounds at least a portion of the first elastic element and is configured to deflect the membrane relative to the longitudinal axis.

Abstract: Systems and methods for multiple beam additive manufacturing use multiple beams of light (e.g., laser light) simultaneously to expose layers of powder material in selected regions until the powder material fuses to form voxels, which form build layers of a three-dimensional structure. The light may be generated from selected light sources and coupled into an array of optical fibers having output ends arranged in an optical head such that the multiple beams are directed by the optical head to different locations on each of the powder layers. The multiple beams may provide distributed exposures forming a distributed exposure pattern including beam spots that are spaced sufficiently to separate the fused regions formed by each exposure. The multiple beams may be moved using various techniques (e.g., by moving the optical head) and according to various scan patterns such that a plurality of multiple beam distributed exposures form each build layer.

Abstract: Devices and methods are disclosed for gaining access to optical fibers contained within a fiber optic cable. Specifically, a cable entry tool can include a first jaw that can have a substantially V-shaped first channel formed therein, a first cutting element extending into the first channel and movable to any of a variety of depths, a second jaw positioned opposing the first jaw and that can have a substantially V-shaped second channel formed therein, and a second cutting element extending into the second channel and movable to any of a variety of depths. The first channel and the second channel can be movable with respect to each other for receiving therebetween a buffer tube having any of a variety of tube diameters.

Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.

Abstract: The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention relates furthermore to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds and to novel intermediates used in the preparation of said compounds.