Abstract: The present invention relates to a method of chemovaccination against Plasmodium infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin X, or a pharmaceutically acceptable salt thereof.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A garment may include a first woven component, a second woven component, a space between the first and second woven components defining a channel filled with a fill material, and a third woven component extending such that the first and second woven components are woven together where there is no channel. The channel may be filled with a filler material. Multiple channels may be provided such that they form a zoned pattern in the garment.

Abstract: A garment may include a first woven component, a second woven component, a space between the first and second woven components defining a channel filled with a fill material, and a third woven component extending such that the first and second woven components are woven together where there is no channel. The channel may be filled with a filler material. Multiple channels may be provided such that they form a zoned pattern in the garment.

Abstract: A garment may include a first woven component, a second woven component, a space between the first and second woven components defining a channel filled with a fill material, and a third woven component extending such that the first and second woven components are woven together where there is no channel. The channel may be filled with a filler material. Multiple channels may be provided such that they form a zoned pattern in the garment.

Abstract: A garment may include a first woven component, a second woven component, a space between the first and second woven components defining a channel filled with a fill material, and a third woven component extending such that the first and second woven components are woven together where there is no channel. The channel may be filled with a filler material. Multiple channels may be provided such that they form a zoned pattern in the garment.

Abstract: A garment may include a first woven component, a second woven component, a space between the first and second woven components defining a channel filled with a fill material, and a third woven component extending such that the first and second woven components are woven together where there is no channel. The channel may be filled with a filler material. Multiple channels may be provided such that they form a zoned pattern in the garment.

Abstract: Data-processing apparatus (30; 320) receives (step 160) data from a data server (20) in a single shot. The apparatus (30; 320) performs a management check (steps 170, 180, 190) on the data, in which the data is checked for compliance with at least one pre-defined criterion. The data and the results of the management check are recorded (step 200). At least one recipient for the data is identified (step 210). The data is processed to conform it to at least one requirement of each identified recipient (step 220). The processed data is delivered to the recipient (step 230).

Abstract: In one aspect, the disclosure is directed to a device for determining and/or indicating a medicament dosage regime. The device may include a housing, a processor, a memory, an input device, and/or an indication device. The dosage determining and/or indicating device is configured for receiving user, e.g., patient, information, medicament information, and/or dosage information, and using that information to determine one or more of the following: the type of medicament recommended to be administered, how often and when the medicament should be administered, how much of the medicament should be administered, potential problematic cross reactivity information, and/or patient compliance information, such as when the when the medicament was last administered, when the medicament is next due to be administered, when a recommended administration was not administered, and the like. The device may further be coupled to an alarm to indicate when a dosage of the medicament is to be delivered.