Abstract: A multi-layer foam film comprising polypropylene for direct and non-direct food contact and aseptic packaging application is disclosed. In an embodiment, the film has a bulk density of less than 0.962 gr/cm3 wherein more than 50% of the cells in the foam layer are closed cells. In an embodiment, the foam films are thick (generally more than 8 mils thick) and have a bending stiffness value of more than 18, in Taber stiffness unit configuration according to TAPPI/ANSI T 489 om-15, and the ratio of the mass per unit area (the mass of a unit area of the film in gram per meter-squared (gr/m2)) over the stiffness value in Taber unit configuration is equal to or less than 13. In an embodiment, the film has a very smooth surface with a smoothness value of less than 25 in Sheffield smoothness unit configuration according to TAPPI T 538. The described foam film can have a water vapor transmission rate value of less than 1 gr/m2/24 hr, according to ASTM E398-13.

Abstract: A multi-layer foam film comprising polypropylene for direct and non-direct food contact and aseptic packaging application is disclosed. In an embodiment, the film has a bulk density of less than 0.962 gr/cm3 wherein more than 50% of the cells in the foam layer are closed cells. In an embodiment, the foam films are thin (generally less than 8 mils thick) and have a bending stiffness value of less than 18, in Taber stiffness unit configuration according to TAPPI/ANSI T 489 om-15, and the ratio of the mass per unit area (the mass of a unit area of the film in gram per meter-squared (gr/m2)) over the stiffness value in Taber unit configuration is equal to or more than 13. In an embodiment, the film has a very smooth surface with a smoothness value of less than 25 in Sheffield smoothness unit configuration according to TAPPI T 538. The described foam film can have a water vapor transmission rate value of less than 1 gr/m2/24 hr, according to ASTM E398-13.

Abstract: A recyclable multilayer synthetic foam container that does not wick, for direct and non-direct food contact and aseptic packaging application is disclosed. In one aspect, a container comprises a pre-creased and/or folded multilayer synthetic foam sheet comprising at least one foam layer, that can be hermetically sealed along the edges, wherein the synthetic board sheet is a recyclable material that does not wick. In another aspect, the product has a bending stiffness value greater than 17 in Taber stiffness unit configuration according to TAPPI/ANSI T 489 om-15. In some embodiments, the product can have an oxygen transmission rate of less than 20 cc/m2/24 hr, according to ASTM D3985. In some embodiments, the product can have a water vapor transmission rate of less than 10 gr/m2/24 hr, according to ASTM E398-13.

Abstract: A recyclable multilayer synthetic foam container that does not wick, for direct and non-direct food contact and aseptic packaging application is disclosed. In one aspect, a container comprises a pre-creased and/or folded multilayer synthetic foam sheet comprising at least one foam layer, that can be hermetically sealed along the edges, wherein the synthetic board sheet is a recyclable material that does not wick. In another aspect, the product has a bending stiffness value greater than 17 in Taber stiffness unit configuration according to TAPPI/ANSI T 489 om-15. In some embodiments, the product can have an oxygen transmission rate of less than 20 cc/m2/24 hr, according to ASTM D3985. In some embodiments, the product can have a water vapor transmission rate of less than 10 gr/m2/24 hr, according to ASTM E398-13.

Abstract: A recyclable multilayer synthetic foam container that does not wick, for direct and non-direct food contact and aseptic packaging application is disclosed. In one aspect, a container comprises a pre-creased and/or folded multilayer synthetic foam sheet comprising at least one foam layer, that can be hermetically sealed along the edges, wherein the synthetic board sheet is a recyclable material that does not wick. In another aspect, the product has a bending stiffness value greater than 17 in Taber stiffness unit configuration according to TAPPI/ANSI T 489 om-15. In some embodiments, the product can have an oxygen transmission rate of less than 20 cc/m2/24 hr, according to ASTM D3985. In some embodiments, the product can have a water vapor transmission rate of less than 10 gr/m2/24 hr, according to ASTM E398-13.

Abstract: The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF? in a mammal.

Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF? in a mammal.

Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF? in a mammal.

Abstract: A method of manufacturing a cylindrical glass optical waveguide preform having a low water content centerline region, for use in the manufacture of optical waveguide fiber, is disclosed. The centerline region of the glass optical waveguide preform has a water content sufficiently low such that an optical waveguide fiber producible from the glass optical waveguide preform of the present invention exhibits an optical attenuation of less than about 0.35 dB/km, and preferably less than about 0.31 dB/km, at a measured wavelength of 1380 nm. Method of manufacture of a porous core mandrel used in the manufacture of such a glass optical waveguide preform is also disclosed.

Abstract: Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with a 2,6-dioxo-3-hydroxypiperidin-5-yl group, which may be further substituted in the 5-position with alkyl or halogeno, and in the 4-position with alkyl or a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNF?. A typical embodiment is 2-(2,6-dioxo-3-hydroxy-5-fluoro-piperidin-5-yl)4-aminoisoindolin-1-one.

Abstract: Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to methods of identifying modulators of angiogenesis utilizing human cells. The methods of the invention can be employed to assay compounds and small molecules for their ability to modulate human angiogenesis utilizing human pluripotent stem cells in an in vitro assay system. The present invention further relates to methods of identifying modulators of human angiogenesis by determining the ability of a test compound to modulate spontaneous vasogenesis in an in vitro assay system utilizing nonembryonic pluripotent stem cells. The present invention relates to in vitro assay systems utilizing nonembryonic pluripotent stem cells for the identification of compounds that modulate human angiogenesis or human vasogenesis.

Abstract: Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF? in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.

Abstract: Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.

Abstract: Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3?,4?-dimethoxyphenyl)propane.

Abstract: 1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF&agr; in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.

Abstract: In general, an educational homeroom provides a central location for a student to receive and interact with educational tools and information that are focused upon a Knowledge Area in which the student has expressed educational interest. When the student expresses educational interest, the educational homeroom dynamically changes such that options made available to the student are always tailored to offer educational tools and information within the student's Knowledge Areas of choice.

Abstract: In general, an Internet based blended learning system provides educational tools to a student in accordance with the student's expressed educational interests. The blended learning system uses multiple educational tools that are tailored toward providing the end-user with complete and efficient educational lessons. Each tailored educational tool is focused upon a knowledge area in which the student has expressed educational interest. Students may complete each educational tool at their own pace, repeat lessons as necessary, and learn according to their own schedule. The blended learning system uses combinations of instructor-led virtual classrooms (I-led), online coaching, interactive computer based training (CBT), knowledge databases, published study guides and books, hands-on exercise labs and/or pre-certification exams.