Abstract: Protein complexes are profound in various biological processes, and their ability to self-associate offers exciting opportunities for innovative biomaterials. However, the weak physical interactions within protein complexes result in limited mechanical stability and fast erosion rates, posing a significant challenge. Thus, a SAv-based hydrogel where SAv tetramers serve as crosslinking junctions is described herein. These mechanically reinforced SAv tetramers significantly enhanced the shear elasticity and decelerated the bioerosion process of the overall material. This simple approach to modulate the mechanical strength of protein complexes as crosslinking junctions present an attractive prospect for a myriad of biotechnological applications, such as biomimetic scaffolds and soft robotics.