Abstract: Formulated and/or co-formulated liposomes (LNP) and solid-lipid nanoparticles (SLNP) comprising TB Prodrugs and methods of making the LNPs and SLNPs are disclosed herein. The TB prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit ALK5. The TB Prodrugs can be formulated and/or co-formulated into a liposome or solid-lipid nanoparticle to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.

Abstract: Formulated and/or co-formulated liposomes comprising TLR prodrugs and/or TLR Lipid Moieties and methods of making the liposomes are disclosed herein. The TLR prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit Toll-Like Receptor (e.g., TLR1/2, TLR4, and/or TLR7). The TLR prodrugs can be formulated and/or co-formulated into a liposome to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.

Abstract: Formulated and/or co-formulated liposomes comprising IDO prodrugs and methods of making the liposomes are disclosed herein. The IDO prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit IDO-1. The IDO prodrugs can be formulated and/or co-formulated into a liposome to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.

Abstract: Fusion Protein compositions comprising masked IFNs and methods of making masked IFNs are disclosed herein. Consequently, the masked IFNs can be fused to a Mab or binding fragment thereof and be administered to patients as a therapeutic modality and provide a method of treating cancer, immunological disorders and other disease.

Abstract: One or more Power Sourcing Equipment (PSE) are coupled to points in a network of interconnected nodes. Each node has a first port and a second port. Assume the first port of a first node is receiving DC power from the PSE. The first node, at its second port, then detects an electrical signature from a first port of an adjacent second node. If the proper electrical signature is presented by the adjacent second node, the powered first node closes a switch to pass power between its first port and second port to power the second node via the first port of the second node. All nodes in the network are then sequentially powered up in this manner. If there is a fault between the first node and the second node, the second node will be powered by another node connected to the second port of the second node.

Abstract: One or more Power Sourcing Equipment (PSE) are coupled to points in a network of interconnected nodes. Each node has a first port and a second port. Assume the first port of a first node is receiving DC power from the PSE. The first node, at its second port, then detects an electrical signature from a first port of an adjacent second node. If the proper electrical signature is presented by the adjacent second node, the powered first node closes a switch to pass power between its first port and second port to power the second node via the first port of the second node. All nodes in the network are then sequentially powered up in this manner. If there is a fault between the first node and the second node, the second node will be powered by another node connected to the second port of the second node.

Abstract: Labelling apparatus, for example for applying labels to articles such as bottles by means of a pressure-sensitive adhesive, includes a presser 20 which comprises an array of freely rotatable rollers 22. Each roller 22 has a resilient surface constituted, for example, by a foam rubber sleeve, and is independently resiliently mounted on a common support 24 by means of springs 36. Labels 16 are partially affixed to bottles 4 which are then rotated about their axes as they pass the presser 20. Resilient contact between the rollers 22 and the label 16 cause the label 16 to be pressed against the surface of the bottle 4 to fix it in place.

Abstract: An electrostatically shielded toroidal plasma and radical source is provided. The plasma source includes a grounded metallic plasma source chamber that defines an interior for plasma generation. The plasma source chamber is configured from two L-shaped portions arranged to form rectangularly shaped enclosure. Dielectric breaks are defined by gaps between the two L-shaped portions. A drive inductor is configured such that the metallic plasma source chamber is positioned between loops of the drive inductor.

Abstract: An electrostatically shielded toroidal plasma and radical source is provided. The plasma source includes a grounded metallic plasma source chamber that defines an interior for plasma generation. The plasma source chamber is configured from two L-shaped portions arranged to form rectangularly shaped enclosure. Dielectric breaks are defined by gaps between the two L-shaped portions. A drive inductor is configured such that the metallic plasma source chamber is positioned between loops of the drive inductor.

Abstract: An electrostatically shielded toroidal plasma and radical source is provided. The plasma source includes a grounded metallic plasma source chamber that defines an interior for plasma generation. The plasma source chamber is configured from two L-shaped portions arranged to form rectangularly shaped enclosure. Dielectric breaks are defined by gaps between the two L-shaped portions. A drive inductor is configured such that the metallic plasma source chamber is positioned between loops of the drive inductor.