Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: A cup holder insert having an insert assembly, a support assembly, and a cup holder assembly is disclosed herein. The adjustable large cup holder insert includes three assemblies each having a specific shape to cooperate with each other. Additionally, the adjustable large cup holder insert is configured to be fitted into an existing cup holder in a vehicle or wherever else a cup holder is found. Each assembly of the adjustable large cup holder insert is fitted into each other to provide a secure attaching means to an existing cup holder. Furthermore, the three assemblies include a cup holder assembly which can be shifted across a support assembly to provide an optimal position for a placing a large cup for a user. The cup holder insert provides a user with an efficient way of securing a large cup to an existing cup holder.