Abstract: A license update engine is run as part of a license entitlement automation system. The license update engine is minimally executed daily and identifies, for example, content updates to be applied and licenses that have drifted from their definition. The license update engine then generates proposals for operators to consider. Accepted proposals update the license configuration. Thus, the license update engine identifies licenses and the definitions that are connected to them, including definitions that the licenses from which the were created and definitions that are linked to SKUs of entitlement purchases. Analyses relates three categories of proposal, including license types, applications linked to licenses, and usage rights on licenses. Proposals are stored in a database and operators can accept or ignore them. The database maintains a history of license changes.

Abstract: A license update engine is run as part of a license entitlement automation system. The license update engine is minimally executed daily and identifies, for example, content updates to be applied and licenses that have drifted from their definition. The license update engine then generates proposals for operators to consider. Accepted proposals update the license configuration. Thus, the license update engine identifies licenses and the definitions that are connected to them, including definitions that the licenses from which the were created and definitions that are linked to SKUs of entitlement purchases. Analyses relates three categories of proposal, including license types, applications linked to licenses, and usage rights on licenses. Proposals are stored in a database and operators can accept or ignore them. The database maintains a history of license changes.

Abstract: A medical bag is described that has a carrying configuration and a dispensing configuration and comprises a handle for carrying the bag and a space within the bag for accommodating a tapered storage drawer, the space tapering from a wide end to a narrow end and the drawer being of a corresponding shape to the space. When the bag is carried by the handle in the carrying configuration, the bottom surface of the space slopes down towards the narrow end so that gravity acts to force the drawer towards the narrow end of the space; however, because of its size, the drawer cannot pass through the narrow end of the space, thereby retaining the tapered storage drawer within the space.

Abstract: This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

Abstract: This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

Abstract: This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

Abstract: A method for sterilizing solid hyaluronic acid includes autoclaving solid hyaluronic acid, whereby the solid hyaluronic acid is exposed to saturated steam at positive gauge pressure for a period of time that is sufficient to sterilize the solid hyaluronic acid. In one embodiment, autoclaving includes exposing the solid hyaluronic acid to saturated steam at a gauge pressure of about one atmosphere for a period of time between about fifteen and thirty minutes.

Abstract: This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

Abstract: This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.

Abstract: A method of treating a wound site wherein a porous, adhesive backed dressing is utilized. A vacuum and/or heat is applied to the wound site through the dressing so as to draw the tissue adjacent the wound site to the dressing so as to minimize trauma to the wound and increase the adherence of the adhesive.

Abstract: Purified Mullerian inhibiting substance (MIS) is obtained from testicular tissue by extraction, density gradient sedimentation and chromatography. The purified MIS has selective activity for inhibiting the growth of human ovarian cancer cells.

Abstract: Solutions of sodium hyaluronate in physiological saline with a kinematic viscosity of from 45,000 to 64,000 cSt. are found to effect a smaller increase in post-operative intra-ocular pressure following use as an aid in opthalmological surgery, when the weight average molecular weight of the hyaluronate is within the range of from 1 to 2 million Daltons.

Abstract: Improved overall yields of hyaluronic acid are obtained by controlling the oxygen available for metabolism by a hyaluronic acid producing microorganism. Relatively high oxygen concentrations are made available during the initial exponential growth phase of the cultivated microorganism, until a predetermined growth has been reached. At this time, the available oxygen is limited to stimulate a disproportionately larger production of the desired hyaluronic acid.

Abstract: A process for purifying Mullerian Inhibiting Substance (MIS) from testicular tissue which comprises incubating testicular tissue in a culture media in the presence of a protease inhibitor in order to extract MIS from the tissue, chromatographing the extract on an anionic exchange resin followed by chromatographing the biologically active product obtained therefrom on a cationic exchange resin; the biologically active material from the cationic exchange resin is chromatographed by lectin affinity chromatography on wheat germ lectin and then either chromatographed by lectin affinity chromatography on concanavalin A or by triazinyl dye affinity chromatography on a appropriate triazinyl dye; MIS is obtained in 8,000-fold and 15,000-fold purification over original testicular tissue.

Abstract: A process for purifying Mullerian Inhibiting Substance (MIS) from testicular tissue which comprises incubating testicular tissue in a culture media in the presence of a protease inhibitor in order to extract MIS from the tissue, chromatographing the extract on an anionic exchange resin followed by chromatographing the biologically active product obtained therefrom on a cationic exchange resin; the biologically active material from the cationic exchange resin is chromatographed by lectin affinity chromatography on wheat germ lectin and then either chromatographed by lectin affinity chromatography on concanavalin A or by triazinyl dye affinity chromatography on an appropriate triazinyl dye; MIS is obtained in 8,000-fold and 15,000-fold purification over original testicular tissue.

Abstract: The present invention provides an electric switch comprising an actuator, a first electrical contact which acts are a fulcrum, a second electrical contact and a contact bridging member. The contact bridging member is slidably movable over the fulcrum and pivots thereabout whereby to bring the leading or trailing end of the member into or out of contact with the second contact. Platform means are provided on the side of the fulcrum remote from the second contact to support the member in a position out of contact with the second contact. A further embodiment provides an electrical switch comprising a plurality of such switching assemblies. A single actuator is adapted to move both the contact bridging members, and the fulcrums of the first and second switch assemblies are positioned to obtain multiposition characteristics.

Abstract: An electrical switch includes a casing, an actuator, and a switch mechanism. The switch mechanism includes a contact bridging member movable between a plurality of spaced electrical contacts. The contacts act as fulcrums on the contact bridging member during its movement to assist in making and breaking the electrical connections. A conductor connects the contact bridging member to one of the contacts or to a second switching mechanism mounted in a common housing.

Abstract: The invention provides a contact bridging member for an electric switch wherein, in use, a contact bridging member is slid by an actuator over a fulcrum and in so doing pivots thereabout to bring the leading end of the member into or out of contact with, or the trailing end out of or into contact with, an electrical contact; the contact bridging member having an abutment member adapted to be acted upon by the actuator in the aforesaid manner and wherein the abutment member projects from one side of the contact bridging member and is an outwardly struck portion thereof.The invention also provides switches incorporating that contact bridging member.The contact bridging member may be curved suitably for use in linearly, arcuately or rotary acting switches.

Abstract: The present invention provides an electric switch having a mechanism comprising an actuator, a contact member capable of being moved along a path by the actuator and two spaced apart electric contacts arranged along said path; wherein one of said contacts functions, in use, as a fulcrum and wherein said member is so shaped and the switch is constructed and arranged such that said member is moveable, from a first position in which it is in contact with said contacts, slideably with respect to said contacts and in so doing initially rotates in one direction and thereafter pivots about the fulcrum in a rotation of opposite direction whereby to come out of contact with the other of said contacts.The above can be applied to a host of switches including those with arcuately, linearly and rotary moveable actuators.