Patents by Inventor David Szymkowski

David Szymkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING NEUROLOGICAL DISEASES
    Publication number: 20230129938
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Application
    Filed: June 20, 2022
    Publication date: April 27, 2023
    Applicant: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • Methods of treating neurological diseases
    Patent number: 11365229
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: June 21, 2022
    Assignee: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • METHODS OF TREATING NEUROLOGICAL DISEASES
    Publication number: 20200172590
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising measuring c-reactive protein in a patient and peripherally administering to the patient a DN-TNF polypeptide that inhibits the activity of soluble TNF-but not transmembrane TNF-?.
    Type: Application
    Filed: April 1, 2019
    Publication date: June 4, 2020
    Applicant: XENCOR, INC.
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • Methods of Treating Neurological Diseases
    Publication number: 20150239951
    Abstract: The present disclosure is directed to a method of treating neurological disorder comprising peripheral administration to a patient in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-?.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 27, 2015
    Inventors: David Szymkowski, Malu Tansey, Lesley Probert
  • TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
    Publication number: 20070172449
    Abstract: Combination therapies comprising novel TNF-? proteins for the treatment of TNF-? related disorders are provided herein.
    Type: Application
    Filed: November 13, 2006
    Publication date: July 26, 2007
    Applicant: Xencor, Inc.
    Inventors: David Carmichael, John Desjarlais, David Szymkowski, Jonathan Zalevsky
  • Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20060257360
    Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
    Type: Application
    Filed: July 27, 2006
    Publication date: November 16, 2006
    Inventors: John Desjarlais, Anton Filikov, Paul Steed, Jonathan Zalevsky, David Szymkowski
  • Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20050265962
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders.
    Type: Application
    Filed: April 14, 2005
    Publication date: December 1, 2005
    Inventors: John Desjarlais, Paul Steed, Jonathan Zalevsky, David Szymkowski
  • Protein based TNF-alpha variants for the treatment of TNF-alpha related disorders
    Publication number: 20050180948
    Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
    Type: Application
    Filed: October 12, 2004
    Publication date: August 18, 2005
    Inventors: John Desjarlais, Anton Filikov, Paul Steed, Jonathan Zalevsky, David Szymkowski
  • Methods and compositions for treating gastrointestinal tract mucin production associated disease conditions
    Publication number: 20050096258
    Abstract: The invention provides a method of treatment for an animal having a disease state associated with a mucus secretion disorder with a chloride channel modulator. The invention further provides for a method of screening for therapeutic compounds using the chloride channel. Also provided is a transgenic animal having a disrupted chloride gene, and a method of diagnosing a disease state associated with a mucus secretion disorder.
    Type: Application
    Filed: October 18, 2004
    Publication date: May 5, 2005
    Inventors: Andrew Grupe, David Szymkowski