Patents by Inventor David T. Beattie

David T. Beattie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccination against anthrax
    Publication number: 20040166120
    Abstract: Methods are disclosed for immunizing a mammal against B. anthracis using a composition of pure recombinant Protective Antigen (rPA), optionally in combination with truncated Lethal Factor polypeptide (LFn). Formulations of the pure rPA immunogen have little or no reactogenicity and therefore may be administered to a mammalian subject in very high doses of 50 &mgr;g to 1000 &mgr;g or more rPA, which is at least four times the amount of PA included per dose in conventional anthrax vaccines. Preferred immunogenic compositions are free of adjuvant and other undesired components, further enhancing the effectiveness and safety of the compositions. Methods for preparing the immunogenic compositions and for purifying rPA and LFn polypeptides also are disclosed.
    Type: Application
    Filed: December 5, 2003
    Publication date: August 26, 2004
    Inventors: Lawrence J. Thomas, Angelo Scorpio, David T. Beattie
  • Sodium channel drugs and uses
    Patent number: 6479498
    Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: November 12, 2002
    Assignee: Theravance, Inc.
    Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins, David C. Green
  • Sodium channel drugs and uses
    Patent number: 6420354
    Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: July 16, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins
  • ama
    Publication number: 20020052472
    Abstract: The invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 12, 2001
    Publication date: May 2, 2002
    Inventors: David T. Beattie, Robert L. Deresiewicz, Adrian M. Lowe, Michael A. Lonetto, John E. Hodgson, Richard O. Nicholas, Leslie Marie Palmer, Julie M. Pratt
  • Ribosome recycling factor (FRR) of Staphylococcus aureus
    Patent number: 6238887
    Abstract: This invention provides frr polypeptides and polynucleotides encoding frr polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing frr polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: May 29, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt
  • UDP-N-acetylmuramoyl-l-alanine:D-glutamate ligase (MURD) of staphylococcus aureus
    Patent number: 6211161
    Abstract: The invention provides murD polypeptides and polynucleotides encoding murD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: April 3, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham plc,
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt, Michael A Lonetto, John E Hodgson
  • Ama
    Patent number: 6197549
    Abstract: This invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 6, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham, plc
    Inventors: Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt, David T. Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson
  • Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase
    Patent number: 6146863
    Abstract: The invention provides hcd polypeptides and polynucleotides encoding Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase (hcd) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hod polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: November 14, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Leslie Marie Palmer, Michael A Lonetto, Richard O Nicholas, Robert L Deresiewicz, Julie M Pratt, John E Hodgson, David T Beattie, Adrian M Lowe
  • ClpL
    Patent number: 6126937
    Abstract: The invention provides clpL polypeptides, polynucleotides encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 3, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc, Virus Research Institute, Brigham & Women's Hospital
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt