Patents by Inventor David T. Burke

David T. Burke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microscale electrophoresis devices for biomolecule separation and detection
    Patent number: 7125478
    Abstract: The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis devices. The device of the present invention utilizes novel fabrication and detection methods.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: October 24, 2006
    Assignee: The Regents of the University of Michigan
    Inventors: Ponnambalam Selvaganapathy, Mark A. Burns, David T. Burke, Carlos H. Mastrangelo
  • Microscale reaction devices
    Patent number: 7066453
    Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: June 27, 2006
    Assignee: The Regents of the University of Michigan
    Inventors: Mark A. Burns, Carlos H. Mastrangelo, Timothy S. Sammarco, Francis P. Man, James R. Webster, Brian N. Johnson, Bradley Foerster, Darren Jones, Yakeitha Fields, Adam Kaiser, David T. Burke
  • Microscale electrophoresis devices for biomolecule separation and detection
    Publication number: 20030213693
    Abstract: The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis devices. The device of the present invention utilizes novel fabrication and detection methods.
    Type: Application
    Filed: January 15, 2003
    Publication date: November 20, 2003
    Applicant: The Regents Of The University Of Michigan
    Inventors: Ponnambalam Selvaganapathy, Mark A. Burns, David T. Burke, Carlos H. Mastrangelo
  • Chip-based isothermal amplification devices and methods
    Publication number: 20020172969
    Abstract: Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.
    Type: Application
    Filed: April 1, 2002
    Publication date: November 21, 2002
    Applicant: The Regents of the University of Michigan
    Inventors: Mark A. Burns, David T. Burke, Brian N. Johnson, John D. DeNuzzio, Wayne F. Beyer
  • Chip-based isothermal amplification devices and methods
    Publication number: 20020168671
    Abstract: Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.
    Type: Application
    Filed: April 1, 2002
    Publication date: November 14, 2002
    Applicant: The Regents of the University of Michigan
    Inventors: Mark A. Burns, David T. Burke, Brian N. Johnson, John D. DeNuzzio, Wayne F. Beyer
  • Chip-based isothermal amplification devices and methods
    Patent number: 6379929
    Abstract: Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: April 30, 2002
    Assignee: The Regents of the University of Michigan
    Inventors: Mark A. Burns, David T. Burke, Brian N. Johnson, John D. DeNuzzio, Wayne F. Beyer, Jr.
  • Microscale devices and reactions in microscale devices
    Publication number: 20010046703
    Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
    Type: Application
    Filed: December 28, 2000
    Publication date: November 29, 2001
    Applicant: The Regents Of The University Of Michigan
    Inventors: Mark A. Burns, Carlos H. Mastrangelo, Timothy S. Sammarco, Francis P. Man, James R. Webster, Brian N. Johnson, Bradley Foerster, Darren Jones, Yakeitha Fields, Adam Kaiser, David T. Burke
  • Microscale devices and reactions in microscale devices
    Patent number: 6057149
    Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: May 2, 2000
    Assignee: The University of Michigan
    Inventors: Mark A. Burns, Carlos H. Mastrangelo, Timothy S. Sammarco, Francis P. Man, James R. Webster, Brian N. Johnson, Bradley Foerster, Darren Jones, Yakeitha Fields, Adam Kaiser, David T. Burke
  • Large DNA cloning system based on yeast artificial chromosomes
    Patent number: 4889806
    Abstract: A large DNA cloning system is disclosed which is based on yeast artificial chromosomes. Cloning vectors are disclosed which allow the cloning of large segments of greater than 50 kb of exogenous DNA. The cloning vector comprises DNA sequences of an autonomous replication sequence, a centromere, a selectable yeast marker, two sequences that seed telomere function in vivo, and a cloning site within an interruptible yeast gene for insertion of the exogenous DNA segments.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: December 26, 1989
    Assignee: Washington University
    Inventors: Maynard V. Olson, David T. Burke