Patents by Inventor David T. Eastlick

David T. Eastlick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing macrolide compounds
    Patent number: 5360917
    Abstract: A process for recovering at least one Antibiotics S541 compound or chemical derivative thereof from solution in an organic solvent, which comprises the steps of contacting the said solution with alumina and adsorbing the compound(s) thereon, eluting the compound(s) and collecting the eluate containing the compounds(s).This method is suitable for the large scale separation of individual S541 compounds or mixtures thereof.
    Type: Grant
    Filed: July 27, 1989
    Date of Patent: November 1, 1994
    Assignee: Glaxo Group Limited
    Inventors: Robert Thornton, David T. Eastlick, Kenneth Briggs
  • Process for the separation of a mixture of "syn" and "anti" oxime isomers
    Patent number: 4876351
    Abstract: A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers.The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7.beta.-position, and of acids corresponding to this 7.beta.-side chain, is described.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: October 24, 1989
    Assignee: Glaxo Group Limited
    Inventors: Colin Robinson, David T. Eastlick, Audrey J. Bownass
  • Process for preparing sodium cefuroxime
    Patent number: 4775750
    Abstract: There is disclosed a process for preparing sodium cefuroxime in very high purity. The process comprises reacting (6R,7R)-7-[Z-2-(fur-2-yl)-2-methoxyimino-acetamido]-3-hydroxymethylceph-3- em-4-carboxylic acid with a halosulphonyl isocyanate in an alkyl acetate solvent, hydrolyzing the resulting intermediate product, forming sodium cefuroxime by the addition of the sodium salt of a weak acid and isolating the sodium cefuroxime in high purity. The use of methyl acetate is particularly preferred and reaction can be carried out at from -25.degree. to +25.degree. C. The hydrolysis, generally in situ, may be carried out at from 10.degree. to 30.degree. C. Fewer steps are required than in previous processes and the product is of higher purity.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: October 4, 1988
    Assignee: Glaxo Group Limited
    Inventors: Herbert J. White, David T. Eastlick, John F. Oughton
  • Process for separation of syn and anti oxime isomers of cephalosporin-compounds
    Patent number: 4717768
    Abstract: A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers.The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7.beta.-position, and of acids corresponding to this 7.beta.-side chain, is described.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: January 5, 1988
    Assignee: Glaxo Group Limited
    Inventors: Colin Robinson, David T. Eastlick, Audrey J. Bownass