Patents by Inventor David T. Eddington
David T. Eddington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11366103Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: GrantFiled: January 13, 2020Date of Patent: June 21, 2022Assignee: Massachusetts Institute of TechnologyInventors: David T. Eddington, Sangeeta N. Bhatia
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Publication number: 20200256852Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: ApplicationFiled: January 13, 2020Publication date: August 13, 2020Inventors: David T. EDDINGTON, Sangeeta N. BHATIA
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Patent number: 10571461Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: GrantFiled: October 12, 2016Date of Patent: February 25, 2020Assignee: Massachusetts Institute of TechnologyInventors: David T. Eddington, Sangeeta N. Bhatia
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Publication number: 20170261496Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: ApplicationFiled: October 12, 2016Publication date: September 14, 2017Inventors: David T. Eddington, Sangeeta N. BHATIA
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Publication number: 20150065389Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: ApplicationFiled: March 26, 2014Publication date: March 5, 2015Applicant: Massachusetts Institute of TechnologyInventors: David T. Eddington, Sangeeta N. BHATIA
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Patent number: 8628517Abstract: A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.Type: GrantFiled: June 23, 2010Date of Patent: January 14, 2014Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Michael J. MacDonald, David T. Eddington, Glennys A. Mensing
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Publication number: 20100262077Abstract: A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.Type: ApplicationFiled: June 23, 2010Publication date: October 14, 2010Inventors: David J. Beebe, Michael J. MacDonald, David T. Eddington, Glennys A. Mensing
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Patent number: 7766902Abstract: A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.Type: GrantFiled: January 22, 2004Date of Patent: August 3, 2010Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Michael J. MacDonald, David T. Eddington, Glennys A. Mensing
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Publication number: 20100170796Abstract: One aspect of the invention relates to a microfluidic device which recreates important features of the human microcirculation on a microscope stage. In certain embodiments of the invention, the clinical scenario associated with ‘sickle cell crisis’ whereby blood vessels are occluded in various organs causing pain and tissue damage can be recreated. In certain embodiments, one can use a device of the invention to study the processes that lead to crisis, and screen therapies (such as small molecules) that might be used to prevent crisis. Further, certain embodiments of the invention allow one to study and screen therapies for a range of human blood disorders, such as hereditary spherocytosis, disorders of white blood cells, such as Waldenstrom's macroglobulinemia or leukocytosis, disorders of blood platelets and coagulation, such as hemophilia A and B, activated protein C resistance, and essential thrombocythemia.Type: ApplicationFiled: February 8, 2008Publication date: July 8, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE OFFICE OFInventors: Sangeeta N. Bhatia, David T. Eddington, John M. Higgins, Lakshminarayanan Mahadevan
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Publication number: 20080220516Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: ApplicationFiled: October 12, 2007Publication date: September 11, 2008Inventors: David T. Eddington, Sangeeta N. Bhatia
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Patent number: 6523559Abstract: In accordance with the present invention, a microfluidic device and method of using the same is provided for self-regulating the flow of fluid therethrough. The microfluidic device includes a body defining first and second flow channels. The first flow channel has an input for receiving the fluid and an output. The second flow channel has an input for receiving a compensating fluid to modify the value of the property of the fluid and an output communicating with the first flow channel. A polymeric material is disposed in the first flow channel downstream of the output of the second flow channel. The polymeric material has a volume responsive to the value of the property of the fluid. A valve is disposed in the second flow channel and is movable in response to the volume of the material. The valve is movable between the first open position allowing the compensating fluid to flow past the valve into the first flow channel and a second closed position limiting the flow of compensating fluid therepast.Type: GrantFiled: July 27, 2001Date of Patent: February 25, 2003Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Jeffrey S. Moore, Robin Liu, David T. Eddington
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Publication number: 20030019520Abstract: In accordance with the present invention, a microfluidic device and method of using the same is provided for self-regulating the flow of fluid therethrough. The microfluidic device includes a body defining first and second flow channels. The first flow channel has an input for receiving the fluid and an output. The second flow channel has an input for receiving a compensating fluid to modify the value of the property of the fluid and an output communicating with the first flow channel. A polymeric material is disposed in the first flow channel downstream of the output of the second flow channel. The polymeric material has a volume responsive to the value of the property of the fluid. A valve is disposed in the second flow channel and is movable in response to the volume of the material. The valve is movable between the first open position allowing the compensating fluid to flow past the valve into the first flow channel and a second closed position limiting the flow of compensating fluid therepast.Type: ApplicationFiled: July 27, 2001Publication date: January 30, 2003Inventors: David J. Beebe, Jeffrey S. Moore, Robin H. Liu, David T. Eddington